概述

描述

  • 性质
    Synthetic
  • 氨基酸序列
    • 种属
      Human
    • 序列
      TRERRKGPAPCDRP
    • 氨基酸
      483 to 490

相关产品

技术指标

Our Abpromise guarantee covers the use of ab22816 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-DOK3 antibody (ab1357)

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • Docking protein 3
    • DOK 3
    • DOK Like Protein
    • Dok3
    • DOK3_HUMAN
    • DOKL Pending
    • Downstream of tyrosine kinase 3
    • p62 DOK Like Protein
    see all
  • 功能
    DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate Abl function.
  • 组织特异性
    Expressed in spleen.
  • 序列相似性
    Belongs to the DOK family. Type A subfamily.
    Contains 1 IRS-type PTB domain.
    Contains 1 PH domain.
  • 结构域
    PTB domain mediates receptor interaction.
  • 翻译后修饰
    Constitutively tyrosine-phosphorylated.
    On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Can also be phosphorylated by ABL kinase.
  • 细胞定位
    Cytoplasm. Cell membrane.
  • Information by UniProt

Human DOK3 peptide (ab22816)参考文献

ab22816 has not yet been referenced specifically in any publications.

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