概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列TRERRKGPAPCDRP
    • 氨基酸483 to 490

相关产品

技术指标

Our Abpromise guarantee covers the use of ab22816 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-DOK3 antibody (ab1357)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • Docking protein 3
    • DOK 3
    • DOK Like Protein
    • Dok3
    • DOK3_HUMAN
    • DOKL Pending
    • Downstream of tyrosine kinase 3
    • p62 DOK Like Protein
    see all
  • 功能DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK3 is a negative regulator of JNK signaling in B-cells through interaction with INPP5D/SHIP1. May modulate Abl function.
  • 组织特异性Expressed in spleen.
  • 序列相似性Belongs to the DOK family. Type A subfamily.
    Contains 1 IRS-type PTB domain.
    Contains 1 PH domain.
  • 结构域PTB domain mediates receptor interaction.
  • 翻译后修饰Constitutively tyrosine-phosphorylated.
    On IL2 stimulation, phosphorylated on C-terminal tyrosine residues possibly by Src kinases. Can also be phosphorylated by ABL kinase.
  • 细胞定位Cytoplasm. Cell membrane.
  • Information by UniProt

Human DOK3 peptide (ab22816)参考文献

ab22816 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab22816.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"