The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-DNA Polymerase lambda antibody (ab5954)
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
DNA directed DNA polymerase lambda
DNA polymerase beta 2
DNA polymerase beta-2
DNA polymerase kappa
DNA polymerase kappa DNA polymerase beta N
DNA polymerase lambda
DNA polymerase lamda2
EC 126.96.36.199,EC 4.2.99.
Polymerase DNA directed lambda
功能Repair polymerase. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Has both DNA polymerase and terminal transferase activities. Has a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.
组织特异性Expressed in a number of tissues. Abundant in testis.
序列相似性Belongs to the DNA polymerase type-X family. Contains 1 BRCT domain.
翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.