概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列RQHARLRVCQKIEKL
    • 氨基酸210 to 224

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技术指标

Our Abpromise guarantee covers the use of ab22902 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-DKK4 antibody (ab2342)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • Dickkopf 4
    • Dickkopf gene 4
    • Dickkopf homolog 4
    • Dickkopf homolog 4 (Xenopus laevis)
    • Dickkopf related protein 4
    • Dickkopf-4
    • Dickkopf-related protein 4 short form
    • Dickkopf4
    • DKK 4
    • Dkk-4
    • DKK4
    • DKK4_HUMAN
    • hDkk 4
    • hDkk-4
    • hDkk4
    • MGC129562
    • MGC129563
    see all
  • 功能Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease.
  • 组织特异性Expressed in cerebellum, T-cells, esophagus and lung.
  • 序列相似性Belongs to the dickkopf family.
  • 结构域The C-terminal cysteine-rich domain mediates interaction with LRP5 and LRP6.
  • 翻译后修饰Appears to be not glycosylated.
    Can be proteolytically processed by a furin-like protease.
  • 细胞定位Secreted.
  • Information by UniProt

Human DKK4 peptide (ab22902)参考文献

ab22902 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"