概述

描述

  • 性质
    Synthetic
  • 氨基酸序列
    • 种属
      Human
    • 序列
      C-QEQLHQLHSRLIS
    • 氨基酸
      1266 to 1278

相关产品

技术指标

Our Abpromise guarantee covers the use of ab23214 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-DCTN1 antibody (ab11806)

  • 形式
    Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • 150 kDa dynein associated polypeptide
    • 150 kDa dynein-associated polypeptide
    • DAP 150
    • DAP-150
    • DAP150
    • DCTN 1
    • DCTN1
    • DCTN1_HUMAN
    • DP 150
    • DP-150
    • DP150
    • Dynactin 1
    • Dynactin 1 (p150 Glued (Drosophila) homolog)
    • Dynactin 1 (p150 glued homolog Drosophila)
    • Dynactin subunit 1
    • Dynactin1
    • HMN7B
    • p135
    • p150 glued
    • p150 Glued (Drosophila) homolog
    • p150 glued homolog
    • p150(GLUED) DROSOPHILA HOMOLOG OF
    • p150-glued
    • p150glued
    see all
  • 功能
    Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles.
  • 组织特异性
    Brain.
  • 疾病相关
    Defects in DCTN1 are the cause of distal hereditary motor neuronopathy type 7B (HMN7B) [MIM:607641]; also known as progressive lower motor neuron disease (PLMND). HMN7B is a neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs.
    Defects in DCTN1 are a cause of susceptibility to amyotrophic lateral sclerosis (ALS) [MIM:105400]. ALS is a neurodegenerative disorder affecting upper and lower motor neurons, and resulting in fatal paralysis. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. The etiology is likely to be multifactorial, involving both genetic and environmental factors.
    Defects in DCTN1 are the cause of Perry syndrome (PERRYS) [MIM:168605]; also called parkinsonism with alveolar hypoventilation and mental depression. Perry syndrome is a neuropsychiatric disorder characterized by mental depression not responsive to antidepressant drugs or electroconvulsive therapy, sleep disturbances, exhaustion and marked weight loss. Parkinsonism develops later and respiratory failure occurred terminally.
  • 序列相似性
    Belongs to the dynactin 150 kDa subunit family.
    Contains 1 CAP-Gly domain.
  • 翻译后修饰
    Ubiquitinated by a SCF complex containing FBXL5, leading to its degradation by the proteasome.
  • 细胞定位
    Cytoplasm. Cytoplasm > cytoskeleton.
  • Information by UniProt

文献

ab23214 has not yet been referenced specifically in any publications.

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