人Cytochrome P450 17A1肽(ab48065)

概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列LFKDGDQKLEK
    • 氨基酸134 to 144

相关产品

技术指标

Our Abpromise guarantee covers the use of ab48065 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

常规信息

  • 别名
    • 20 lyase
    • CP17A_HUMAN
    • CPT7
    • CYP17
    • CYP17A1
    • CYPXVII
    • Cytochrome P450 17A1
    • Cytochrome P450 family 17
    • Cytochrome P450 family 17 subfamily A polypeptide 1
    • Cytochrome p450 subfamily XVII (steroid 17 alpha hydroxylase) adrenal hyperplasia
    • Cytochrome p450 XVIIA1
    • Cytochrome P450-C17
    • Cytochrome P450c17
    • OTTHUMP00000020382
    • P450 C17
    • P450c17
    • S17AH
    • Steroid 17 alpha hydroxylase/17,20 lyase
    • Steroid 17 alpha monooxygenase
    • Steroid 17-alpha-hydroxylase/17
    • Steroid 17-alpha-monooxygenase
    see all
  • 功能Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.
  • 通路Lipid metabolism; steroid biosynthesis.
  • 疾病相关Defects in CYP17A1 are the cause of adrenal hyperplasia type 5 (AH5) [MIM:202110]. AH5 is a form of congenital adrenal hyperplasia, a common recessive disease due to defective synthesis of cortisol. Congenital adrenal hyperplasia is characterized by androgen excess leading to ambiguous genitalia in affected females, rapid somatic growth during childhood in both sexes with premature closure of the epiphyses and short adult stature. Four clinical types: "salt wasting" (SW, the most severe type), "simple virilizing" (SV, less severely affected patients), with normal aldosterone biosynthesis, "non-classic form" or late onset (NC or LOAH), and "cryptic" (asymptomatic).
  • 序列相似性Belongs to the cytochrome P450 family.
  • 翻译后修饰Phosphorylation is necessary for 17,20-lyase, but not for 17-alpha-hydroxylase activity.
  • 细胞定位Membrane.
  • Information by UniProt

Human Cytochrome P450 17A1 peptide (ab48065)参考文献

ab48065 has not yet been referenced specifically in any publications.

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