概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列C-YPDSDVLFRYKVKS
    • 氨基酸493 to 506

相关产品

技术指标

Our Abpromise guarantee covers the use of ab45557 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-CYP7B1 antibody (ab19043)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

常规信息

  • 别名
    • 25 hydroxycholesterol 7 alpha hydroxylase
    • 25-hydroxycholesterol 7-alpha-hydroxylase
    • CP7B
    • CP7B1_HUMAN
    • Cyp7b1
    • Cytochrome P450 7B1
    • Cytochrome P450 family 7 subfamily B polypeptide 1
    • Cytochrome P450 subfamily VIIB polypeptide 1
    • Oxysterol 7-alpha-hydroxylase
    • Oxysterol 7alpha hydroxylase
    see all
  • 组织特异性Brain, testis, ovary, prostate, liver, colon, kidney, and small intestine.
  • 通路Lipid metabolism; bile acid biosynthesis.
  • 疾病相关Defects in CYP7B1 are the cause of spastic paraplegia autosomal recessive type 5A (SPG5A) [MIM:270800]. Spastic paraplegia is a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.
    Defects in CYP7B1 are the cause of congenital bile acid synthesis defect type 3 (CBAS3) [MIM:613812]. Clinical features include severe cholestasis, cirrhosis and liver synthetic failure. Hepatic microsomal oxysterol 7-alpha-hydroxylase activity is undetectable.
  • 序列相似性Belongs to the cytochrome P450 family.
  • 细胞定位Endoplasmic reticulum membrane. Microsome membrane.
  • Information by UniProt

Human CYP7B1 peptide (ab45557)参考文献

ab45557 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab45557.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"