概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列An 18 amino acid synthetic peptide whose sequences are derived from human CPEB protein. The sequence of this peptide is (amino to carboxy terminus): CH(545)SMEGLRHHSPLMRNQKN(562).
    • 氨基酸545 to 562

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技术指标

Our Abpromise guarantee covers the use of ab4988 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • 补充说明


    This peptide may be used for neutralization and control experiments with the polyclonal antibody that reacts with this product and the human CPEB, ab3465. Using a solution with equal weights per unit volume of peptide and corresponding antibody will yield a solution with a large molar excess of peptide that is able to competitively bind the antibody.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • CEBP
    • CPE binding protein 1
    • CPE BP1
    • CPE-binding protein 1
    • CPE-BP1
    • CPEB
    • CPEB 1
    • CPEB-1
    • CPEB1
    • CPEB1 protein
    • CPEB1_HUMAN
    • Cytoplasmic polyadenylation binding protein 1
    • Cytoplasmic polyadenylation element binding protein
    • Cytoplasmic polyadenylation element binding protein 1
    • Cytoplasmic polyadenylation element-binding protein 1
    • FLJ13203
    • h CEBP
    • h-CEBP
    • hCPEB 1
    • hCPEB-1
    • MGC34136
    • MGC60106
    • mKIAA0940
    • MKIAA0940 protein
    see all
  • 功能Sequence-specific RNA-binding protein that regulates mRNA cytoplasmic polyadenylation and translation initiation during oocyte maturation, early development and at postsynapse sites of neurons. Binds to the cytoplasmic polyadenylation element (CPE), an uridine-rich sequence element (consensus sequence 5'-UUUUUAU-3') within the mRNA 3'-UTR. In absence of phosphorylation and in association with TACC3 is also involved as a repressor of translation of CPE-containing mRNA; a repression that is relieved by phosphorylation or degradation (By similarity). Involved in the transport of CPE-containing mRNA to dendrites; those mRNAs may be transported to dendrites in a translationally dormant form and translationally activated at synapses (By similarity). Its interaction with APLP1 promotes local CPE-containing mRNA polyadenylation and translation activation (By similarity). Induces the assembly of stress granules in the absence of stress.
  • 组织特异性Isoform 1 is expressed in immature oocytes, ovary, brain and heart. Isoform 2 is expressed in brain and heart. Isoform 3 and isoform 4 are expressed in brain. Expressed in breast tumors and several tumor cell lines.
  • 序列相似性Belongs to the RRM CPEB family.
    Contains 2 RRM (RNA recognition motif) domains.
  • 结构域The 2 RRM domains and the C-terminal region mediate interaction with CPE-containing RNA.
  • 翻译后修饰Phosphorylated on serine/threonine residues by AURKA/STK6 within positions 166 and 197. Phosphorylation and dephosphorylation on Thr-172 regulates cytoplasmic polyadenylation and translation of CPE-containing mRNAs. Phosphorylation on Thr-172 by AURKA/STK6 and CAMK2A activates CPEB1. Phosphorylation on Thr-172 may be promoted by APLP1. Phosphorylation increases binding to RNA.
  • 细胞定位Cytoplasm > P-body. Cytoplasmic granule. Cell junction > synapse. Membrane. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell projection > dendrite. Also found in stress granules. Recruited to stress granules (SGs) upon arsenite treatment. In dendrites (By similarity). Localizes in synaptosomes at dendritic synapses of neurons (By similarity). Strongly enriched in postsynaptic density (PSD) fractions (By similarity). Transported into dendrites in a microtubule-dependent fashion and colocalizes in mRNA-containing particles with TACC3, dynein and kinesin (By similarity). Membrane-associated (By similarity). Colocalizes at excitatory synapses with members of the polyadenylation and translation complex factors (CPSF, APLP1, TACC3, AURKA/STK6, SYP, etc.) including CPE-containing RNAs.
  • Information by UniProt

Human CPEB1 peptide (ab4988)参考文献

ab4988 has not yet been referenced specifically in any publications.

Product Wall

Thank you for your enquiry. The CPEB (cytoplasmic polyadenylation element binding protein) peptide was created to be used as an immunogen for our anti-CPEB antibody. It can be used to neutralize the protein detecting CPEB in control experiments. We do ...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"