概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列C-QDQESSPIENDSSP
    • 氨基酸284 to 297

相关产品

技术指标

Our Abpromise guarantee covers the use of ab22803 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-CD20 antibody (ab1310)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • APY
    • ATOPY
    • B lymphocyte antigen CD20
    • B Lymphocyte Cell Surface Antigen B1
    • B-lymphocyte antigen CD20
    • B-lymphocyte cell-surface antigen B1
    • B-lymphocyte surface antigen B1
    • B1
    • Bp 35
    • Bp35
    • CD 20
    • CD20
    • CD20 antigen
    • CD20 receptor
    • CD20_HUMAN
    • CVID5
    • Fc epsilon receptor I beta chain
    • Fc Fragment of IgE high affinity I receptor for beta polypeptide
    • FCER1B
    • High affinity immunoglobulin epsilon receptor subunit beta
    • IgE Fc receptor subunit beta
    • IGEL
    • IGER
    • IGHER
    • LEU 16
    • LEU16
    • leukocyte surface antigen Leu 16
    • Leukocyte surface antigen Leu-16
    • Ly44
    • Membrane spanning 4 domains A1
    • Membrane spanning 4 domains subfamily A member 2
    • Membrane-spanning 4-domains subfamily A member 1
    • MS4A1
    • MS4A2
    • S7
    see all
  • 功能This protein may be involved in the regulation of B-cell activation and proliferation.
  • 组织特异性Expressed on B-cells.
  • 疾病相关Defects in MS4A1 are the cause of immunodeficiency common variable type 5 (CVID5) [MIM:613495]; also called antibody deficiency due to CD20 defect. CVID5 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
  • 序列相似性Belongs to the MS4A family.
  • 翻译后修饰Phosphorylated. Might be functionally regulated by protein kinase(s).
  • 细胞定位Membrane.
  • Information by UniProt

Human CD20 peptide (ab22803)参考文献

ab22803 has not yet been referenced specifically in any publications.

Product Wall

Thank you for contacting us.

Unfortunately, neither of these peptides overlap with the binding site recognized by Rituximab, which according to the reference PMID 16705086 bind to a discontiguous epitope comprised of amino acids 170-173 and 1...

Read More

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"