概述

描述

  • 性质
    Synthetic
  • 氨基酸序列
    • 种属
      Human
    • 序列
      VHRWPSARVRQTWS
    • 氨基酸
      206 to 219

相关产品

技术指标

Our Abpromise guarantee covers the use of ab42263 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-CCKBR antibody (ab14440)

  • 形式
    Lyophilised
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. After reconstitution store at -20ºC. Avoid freeze / thaw cycles.

    Preservative: None
    Constituents: 0.1% Acetic acid

  • 复溶
    Resuspend in 0.1% acetic acid for required concentration.

常规信息

  • 别名
    • CCK B
    • CCK B receptor
    • CCK BR
    • CCK-B receptor
    • CCK-BR
    • CCK2 R
    • CCK2 receptor
    • CCK2-R
    • CCKB
    • CCKB receptor
    • CCKBR
    • CCKR Type B
    • CCKRB
    • Cholecystokinin 2 receptor
    • Cholecystokinin B receptor
    • Cholecystokinin-2 receptor
    • Cholecystokinin2 receptor
    • CholecystokininB receptor
    • GASR
    • GASR_HUMAN
    • Gastrin receptor
    • Gastrin/cholecystokinin type B receptor
    • Gastrin\cholecystokinin brain receptor
    see all
  • 功能
    Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
    Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism.
  • 组织特异性
    Isoform 1 is expressed in brain, pancreas, stomach, the colon cancer cell line LoVo and the T-lymphoblastoma Jurkat, but not in heart, placenta, liver, lung, skeletal muscle, kidney or the stomach cancer cell line AGS. Expressed at high levels in the small cell lung cancer cell line NCI-H510, at lower levels in NCI-H345, NCI-H69 and GLC28 cell lines, not expressed in GLC19 cell line. Within the stomach, expressed at high levels in the mucosa of the gastric fundus and at low levels in the antrum and duodenum. Isoform 2 is present in pancreatic cancer cells and colorectal cancer cells, but not in normal pancreas or colonic mucosa. Isoform 3 is expressed in brain, pancreas, stomach, the stomach cancer cell line AGS and the colon cancer cell line LoVo.
  • 序列相似性
    Belongs to the G-protein coupled receptor 1 family.
  • 细胞定位
    Cell membrane.
  • Information by UniProt

文献

ab42263 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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