概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列C-QRKTIWVDEDQL
    • 氨基酸1131 to 1147

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技术指标

Our Abpromise guarantee covers the use of ab23025 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-CARD11 antibody (ab4358)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • 0610008L17Rik
    • 2410011D02Rik
    • Bcl10 interacting maguk protein 3
    • BIMP 3
    • BIMP3
    • CAR11_HUMAN
    • CARD 11
    • CARD containing MAGUK protein 3
    • Card maguk protein 1
    • CARD-containing MAGUK protein 1
    • CARD11
    • CARD11 protein
    • Carma 1
    • CARMA1
    • Caspase recruitment domain containing protein 11
    • Caspase recruitment domain family member 11
    • Caspase recruitment domain-containing protein 11
    • MGC133069
    see all
  • 功能Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Activates NF-kappa-B via BCL10 and IKK. Stimulates the phosphorylation of BCL10.
  • 组织特异性Detected in adult peripheral blood leukocytes, thymus, spleen and liver. Also found in promyelocytic leukemia HL-60 cells, chronic myelogenous leukemia K562 cells, Burkitt's lymphoma Raji cells and colorectal adenocarcinoma SW480 cells. Not detected in HeLa S3, Molt-4, A549 and G431 cells.
  • 序列相似性Contains 1 CARD domain.
    Contains 1 guanylate kinase-like domain.
    Contains 1 PDZ (DHR) domain.
  • 翻译后修饰Phosphorylation at Ser-559, Ser-644 and Ser-652 by PRKCBB leads to a shift from an inactive to an active form that activates the NF-kappa-B signaling.
  • 细胞定位Cytoplasm. Membrane raft. Colocalized with DPP4 in membrane rafts.
  • Information by UniProt

Human CARD11 peptide (ab23025)参考文献

ab23025 has not yet been referenced specifically in any publications.

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