The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-Bim antibody (ab17031)
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Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
BCL2 like 11
Bcl 2 interacting protein Bim
Bcl 2 related ovarian death agonist
Bcl-2-like protein 11
BCL2 interacting mediator of cell death
BCL2 like 11 (apoptosis facilitator)
BCL2 like protein 11
Bcl2-interacting mediator of cell death
功能Induces apoptosis. Isoform BimL is more potent than isoform BimEL. Isoform Bim-alpha1, isoform Bim-alpha2 and isoform Bim-alpha3 induce apoptosis, although less potent than the isoforms BimEL, BimL and BimS. Isoform Bim-gamma induces apoptosis.
组织特异性Isoform BimEL, isoform BimL and isoform BimS are the predominant isoforms and are ubiquitously expressed with a tissue-specific variation. Isoform Bim-gamma is most abundantly expressed in small intestine and colon, and in lower levels in spleen, prostate, testis, heart, liver and kidney.
序列相似性Belongs to the Bcl-2 family.
结构域The BH3 motif is required for Bcl-2 binding and cytotoxicity.
细胞定位Mitochondrion and Endomembrane system. Associated with intracytoplasmic membranes.