概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列LSATPLYGNVHSW-C
    • 氨基酸2 to 14

相关产品

技术指标

Our Abpromise guarantee covers the use of ab23093 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-BCOR antibody (ab5276)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • 5830466J11Rik
    • 8430401K06Rik
    • ANOP 2
    • ANOP2
    • BCL 6 co repressor
    • BCL 6 corepressor
    • BCL 6 interacting corepressor
    • BCL-6 corepressor
    • BCL6 co repressor
    • BCL6 corepressor
    • BCL6 interacting corepressor
    • BCoR
    • BCOR_HUMAN
    • FLJ20285
    • FLJ38041
    • KIAA1575
    • MAA 2
    • MAA2
    • MCOPS 2
    • MCOPS2
    • MGC131961
    • MGC71031
    see all
  • 功能Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).
  • 组织特异性Ubiquitously expressed.
  • 疾病相关Defects in BCOR are the cause of microphthalmia syndromic type 2 (MCOPS2) [MIM:300166]. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS2 is a very rare multiple congenital anomaly syndrome characterized by eye anomalies (congenital cataract, microphthalmia, or secondary glaucoma), facial abnormalities (long narrow face, high nasal bridge, pointed nose with cartilages separated at the tip, cleft palate, or submucous cleft palate), cardiac anomalies (atrial septal defect, ventricular septal defect, or floppy mitral valve) and dental abnormalities (canine radiculomegaly, delayed dentition, oligodontia, persistent primary teeth, or variable root length).
  • 序列相似性Belongs to the BCOR family.
    Contains 3 ANK repeats.
  • 细胞定位Nucleus.
  • Information by UniProt

Human BCOR peptide (ab23093)参考文献

ab23093 has not yet been referenced specifically in any publications.

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