概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • AccessionQ07817
    • 种属Human
    • 额外的序列信息Synthetic peptide surrounding amino acid 56 of human Bcl-xL

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技术指标

Our Abpromise guarantee covers the use of ab52114 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-Bcl-XL antibody (ab2568)

  • 纯度> 90 % SDS-PAGE.

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: 0.02% Thimerosal (merthiolate)
    Constituents: 0.1% BSA, PBS, pH 7.2

常规信息

  • 别名
    • Apoptosis regulator Bcl X
    • Apoptosis regulator Bcl-X
    • Apoptosis regulator BclX
    • B cell lymphoma 2 like
    • B2CL1_HUMAN
    • Bcl 2 like 1 protein
    • Bcl X
    • Bcl xL
    • BCL XL/S
    • Bcl xS
    • Bcl-2-like protein 1
    • Bcl2 Like 1
    • Bcl2 related gene
    • Bcl2-L-1
    • BCL2L
    • Bcl2l1
    • BCLX
    • BclXL
    • BclXs
    • DKFZp781P2092
    • PPP1R52
    • Protein phosphatase 1 regulatory subunit 52
    see all
  • 功能Potent inhibitor of cell death. Inhibits activation of caspases (By similarity). Appears to regulate cell death by blocking the voltage-dependent anion channnel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane.
    Isoform Bcl-X(S) promotes apoptosis.
  • 组织特异性Bcl-X(S) is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. In contrast, Bcl-X(L) is found in tissues containing long-lived postmitotic cells, such as adult brain.
  • 序列相似性Belongs to the Bcl-2 family.
  • 结构域The BH4 motif is required for anti-apoptotic activity. The BH1 and BH2 motifs are required for both heterodimerization with other Bcl-2 family members and for repression of cell death.
  • 翻译后修饰Proteolytically cleaved by caspases during apoptosis. The cleaved protein, lacking the BH4 motif, has pro-apoptotic activity.
  • 细胞定位Mitochondrion membrane. Nucleus membrane. Mitochondrial membranes and perinuclear envelope.
  • Information by UniProt

Human Bcl-XL peptide (ab52114)参考文献

ab52114 has not yet been referenced specifically in any publications.

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