概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列CVMSFELLPLDS
    • 氨基酸766 to 777

技术指标

Our Abpromise guarantee covers the use of ab23008 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • BARD-1
    • Bard1
    • BARD1_HUMAN
    • BRCA1 associated RING domain 1
    • BRCA1 associated RING domain gene 1
    • BRCA1 associated RING domain protein 1
    • BRCA1-associated RING domain protein 1
    see all
  • 功能Probable E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.
  • 通路Protein modification; protein ubiquitination.
  • 序列相似性Contains 4 ANK repeats.
    Contains 2 BRCT domains.
    Contains 1 RING-type zinc finger.
  • 翻译后修饰Processed during apoptosis. The homodimer is more susceptible to proteolytic cleavage than the BARD1/BRCA1 heterodimer.
  • 细胞定位Nucleus. During S phase of the cell cycle, colocalizes with BRCA1 into discrete subnuclear foci. Can translocate to the cytoplasm. Localizes at sites of DNA damage at double-strand breaks (DSBs); recruitment to DNA damage sites is mediated by the BRCA1-A complex.
  • Information by UniProt

Human BARD1 peptide (ab23008)参考文献

ab23008 has not yet been referenced specifically in any publications.

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