The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-Bak antibody (ab2273)
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Apoptosis regulator BAK
Bcl 2 homologous antagonist/killer
Bcl 2 like 7 protein
Bcl-2 homologous antagonist/killer
Bcl-2-like protein 7
BCL2 antagonist/killer 1
Bcl2 like 7 Protein
Cell death inhibitor 1
Pro apoptotic protein BAK
功能In the presence of an appropriate stimulus, accelerates programmed cell death by binding to, and antagonizing the anti-apoptotic action of BCL2 or its adenovirus homolog E1B 19k protein. Low micromolar levels of zinc ions inhibit the promotion of apoptosis.
组织特异性Expressed in a wide variety of tissues, with highest levels in the heart and skeletal muscle.
序列相似性Belongs to the Bcl-2 family.
结构域Intact BH3 motif is required by BIK, BID, BAK, BAD and BAX for their pro-apoptotic activity and for their interaction with anti-apoptotic members of the Bcl-2 family.