概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列C-SGSGTLVSTV
    • 氨基酸512 to 520

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技术指标

Our Abpromise guarantee covers the use of ab23256 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-BAIAP2 antibody (ab15697)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • BAI-associated protein 2
    • BAI1 associated protein 2
    • BAI1-associated protein 2
    • BAIAP 2
    • Baiap2
    • BAIP2_HUMAN
    • BAP2
    • Brain-specific angiogenesis inhibitor 1-associated protein 2
    • Fas ligand-associated factor 3
    • FLAF3
    • Insulin receptor substrate p53
    • Insulin receptor substrate p53/p58
    • Insulin receptor substrate protein of 53 kDa
    • IRS-58
    • IRSp53
    • IRSp53/58
    • Protein BAP2
    see all
  • 功能Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation.
  • 组织特异性Isoform 1 and isoform 4 are expressed almost exclusively in brain. Isoform 4 is barely detectable in placenta, prostate and testis. A short isoform is ubiquitous, with the highest expression in liver, prostate, testis and placenta.
  • 序列相似性Contains 1 IMD (IRSp53/MIM homology) domain.
    Contains 1 SH3 domain.
  • 结构域The IMD domain forms a coiled coil. The isolated domain can induce actin bundling and filopodia formation. In the absence of G-proteins intramolecular interaction between the IMD and the SH3 domain gives rise to an auto-inhibited state of the protein. Interaction of the IMD with RAC1 or CDC42 leads to activation.
    The SH3 domain interacts with ATN1, BAI1, WASF1, WASF2, SHANK1, DIAPH1 and ENAH.
  • 翻译后修饰Phosphorylated on tyrosine residues by INSR in response to insulin treatment.
  • 细胞定位Cytoplasm. Membrane. Cell projection > filopodium. Cell projection > ruffle. Detected throughout the cytoplasm in the absence of specific binding partners. Detected in filopodia and close to membrane ruffles.
  • Information by UniProt

Human BAIAP2 peptide (ab23256)参考文献

ab23256 has not yet been referenced specifically in any publications.

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