概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列YEEGGKQCVERKCP
    • 氨基酸416 to 429

相关产品

技术指标

Our Abpromise guarantee covers the use of ab23271 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-BAF53A antibody (ab15718)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • 53 kDa BRG1 associated factor A
    • Actin like 6A
    • Actin like protein 6A
    • Actin related protein
    • Actin related protein Baf53a
    • actin-related protein 4
    • ACTL 6
    • ACTL 6A
    • ACTL6
    • ACTL6A
    • Arp4
    • ARPN BETA
    • ArpNbeta
    • BAF 53
    • BAF 53A
    • BAF complex 53 kDa subunit
    • BAF53
    • BRG1 associated factor
    • BRG1 associated factor 53A
    • BRG1/brm associated factor 53A
    • hArpN beta
    • INO80 complex subunit K
    • INO80K
    • MGC5382
    see all
  • 相关性This protein is a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This protein is a 53 kDa subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. It is required for maximal ATPase activity of SMARCA4/BRG1 and for association of the SMARCA4/BRG1 containing remodelling complex BAF with chromatin/nuclear matrix. It is a component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage.
  • 细胞定位Nuclear

Human BAF53A peptide (ab23271)参考文献

ab23271 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"