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别名
- APP beta secretase
- Asp 2
- ASP2
- Aspartyl protease 2
- BACE
- BACE 1
- BACE1
- BACE1_HUMAN
- Beta secretase
- Beta secretase 1
- Beta site amyloid beta A4 precursor protein cleaving enzyme
- Beta site amyloid precursor protein cleaving enzyme
- Beta site amyloid precursor protein cleaving enzyme 1
- Beta site APP cleaving enzyme
- Beta site APP cleaving enzyme 1
- Beta-secretase 1
- Beta-site amyloid precursor protein cleaving enzyme 1
- Beta-site APP cleaving enzyme 1
- FLJ90568
- HSPC104
- Memapsin 2
- Memapsin-2
- Memapsin2
- Membrane associated aspartic protease 2
- Membrane-associated aspartic protease 2
- Transmembrane aspartic proteinase Asp2
see all
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功能
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
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组织特异性
Expressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata.
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序列相似性
Belongs to the peptidase A1 family.
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结构域
The transmembrane domain is necessary for its activity. It determines its late Golgi localization and access to its substrate, APP.
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翻译后修饰
Glycosylated.
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细胞定位
Membrane. Golgi apparatus > trans-Golgi network. Endoplasmic reticulum. Endosome. Cell surface. Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface.
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Information by UniProt