人BACE1肽(ab41766)

常规信息

• 别名
  • APP beta secretase
  • Asp 2
  • ASP2

  • Aspartyl protease 2
  • BACE
  • BACE 1
  • BACE1
  • BACE1_HUMAN
  • Beta secretase
  • Beta secretase 1
  • Beta site amyloid beta A4 precursor protein cleaving enzyme
  • Beta site amyloid precursor protein cleaving enzyme
  • Beta site amyloid precursor protein cleaving enzyme 1
  • Beta site APP cleaving enzyme
  • Beta site APP cleaving enzyme 1
  • Beta-secretase 1
  • Beta-site amyloid precursor protein cleaving enzyme 1
  • Beta-site APP cleaving enzyme 1
  • FLJ90568
  • HSPC104
  • Memapsin 2
  • Memapsin-2
  • Memapsin2
  • Membrane associated aspartic protease 2
  • Membrane-associated aspartic protease 2
  • Transmembrane aspartic proteinase Asp2

  see all
• 功能Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
• 组织特异性Expressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata.
• 序列相似性Belongs to the peptidase A1 family.
• 结构域The transmembrane domain is necessary for its activity. It determines its late Golgi localization and access to its substrate, APP.
• 翻译后修饰Glycosylated.
• 细胞定位Membrane. Golgi apparatus > trans-Golgi network. Endoplasmic reticulum. Endosome. Cell surface. Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface.

• Target information above from: UniProt accession P56817 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt