概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human
    • 序列C-ELKTLKDLYSNKS
    • 氨基酸258 to 270

技术指标

Our Abpromise guarantee covers the use of ab22788 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

常规信息

  • 别名
    • Activating transcription factor 1
    • ATF 1
    • atf1
    • ATF1 EWS fusion gene
    • ATF1 FUS fusion gene
    • ATF1_HUMAN
    • cAMP dependent transcription factor 1
    • cAMP-dependent transcription factor ATF-1
    • Cyclic AMP dependent transcription factor ATF 1
    • Cyclic AMP dependent transcription factor ATF1
    • Cyclic AMP-dependent transcription factor ATF-1
    • EWS AFT1
    • FUS ATF 1
    • FUS/ATF 1
    • Protein TREB36
    • RNA binding protein activating transcription factor 1 fusion protein
    • TREB 36
    • TREB36
    • TREB36 protein
    see all
  • 功能This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes.
  • 疾病相关Defects in ATF1 may be a cause of angiomatoid fibrous histiocytoma (AFH) [MIM:612160]. A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis. Note=Chromosomal aberrations involving ATF1 are found in patients with angiomatoid fibrous histiocytoma. Translocation t(12;16)(q13;p11.2) with FUS generates a chimeric ATF1/FUS protein. Translocation t(12;22)(q13;q12) with EWSR1 generates a chimeric ATF1/EWSR1 protein.
  • 序列相似性Belongs to the bZIP family. ATF subfamily.
    Contains 1 bZIP domain.
    Contains 1 KID (kinase-inducible) domain.
  • 细胞定位Nucleus.
  • Information by UniProt

Human ATF1 peptide (ab22788)参考文献

ab22788 has not yet been referenced specifically in any publications.

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