- 氨基酸697 to 703
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- Adapter protein containing PH domain
- Adaptor Protein Containing pH Domain
- Adaptor protein containing pH domain PTB domain and leucine zipper motif
- 功能Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction.
- 组织特异性High levels in heart, ovary, pancreas and skeletal muscle.
- 序列相似性Contains 1 PH domain.
Contains 1 PID domain.
- 结构域Overexpression of an N-terminal domain (residues 1-319) or a C-terminal region (residues 273-709) has a proapoptotic effect.
- 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
- 细胞定位Early endosome membrane. Nucleus. Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF.
Information by UniProt
Human APPL peptide (ab23103)参考文献
has not yet been referenced specifically in any publications.
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