697 to 703
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
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- Adapter protein containing PH domain
- Adaptor Protein Containing pH Domain
- Adaptor protein containing pH domain PTB domain and leucine zipper motif
Required for the regulation of cell proliferation in response to extracellular signals from an early endosomal compartment. Links Rab5 to nuclear signal transduction.
High levels in heart, ovary, pancreas and skeletal muscle.
Contains 1 PH domain.
Contains 1 PID domain.
Overexpression of an N-terminal domain (residues 1-319) or a C-terminal region (residues 273-709) has a proapoptotic effect.
Phosphorylated upon DNA damage, probably by ATM or ATR.
Early endosome membrane. Nucleus. Early endosomal membrane-bound and nuclear. Translocated into the nucleus upon release from endosomal membranes following internalization of EGF.
Information by UniProt
has not yet been referenced specifically in any publications.
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