人Aldolase intron 2 ChIP引物and Probe Set (ab85773)

概述

  • 产品名称人Aldolase intron 2 ChIP引物and Probe Set
  • 产品概述

    Accession number: NM_184043.
    The HsALDOA primers and probe can be can be used to quantify a control locus in chromatin immunoprecipitation (ChIP) assays with chromatin prepared from human cells.

    ALDOA (Fructose-bisphosphate aldolase A) is a moderately expressed housekeeping gene. The primers and probe are located in intron 2, within 1 kb of the transcription start site. In most cell types, this locus is enriched with histone modifications associated with active gene transcription such as Histone H3 K9 acetylation (see image with ab4441). Whereas it shows low levels of histone modifications associated with silencing such as Histone H3 K9 tri methylation (see image with ab8898).

性能

  • 功能Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein.
  • 通路Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.
  • 疾病相关Defects in ALDOA are the cause of glycogen storage disease type 12 (GSD12) [MIM:611881]; also known as red cell aldolase deficiency. A metabolic disorder associated with increased hepatic glycogen and hemolytic anemia. It may lead to myopathy with exercise intolerance and rhabdomyolysis.
  • 序列相似性Belongs to the class I fructose-bisphosphate aldolase family.
  • Information by UniProt
  • 别名
    • ALDA
    • Aldo1
    • ALDOA
    • ALDOA_HUMAN
    • Aldolase 1
    • Aldolase A
    • Aldolase A fructose bisphosphatase
    • Aldolase A fructose bisphosphate
    • FRUCTOALDOLASE A
    • Fructose 1 6 bisphosphate triosephosphate lyase
    • Fructose bisphosphate aldolase
    • Fructose bisphosphate aldolase A
    • FRUCTOSE-1,6-BISPHOSPHATE ALDOLASE A
    • Fructose-bisphosphate aldolase A
    • Fructose-bisphosphate aldolase A Muscle-type
    • GSD12
    • Lung cancer antigen NY LU 1
    • Lung cancer antigen NY-LU-1
    • MGC10942
    • MGC17716
    • MGC17767
    • Muscle type aldolase
    • Muscle-type aldolase
    • RNALDOG5
    see all

Human Aldolase intron 2 ChIP Primer and Probe Set (ab85773)参考文献

ab85773 has not yet been referenced specifically in any publications.

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