The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Blocking - Blocking peptide for Anti-AIBZIP antibody (ab2474)
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Androgen induced basic leucine zipper
Androgen induced basic leucine zipper protein
Androgen-induced basic leucine zipper protein
Attaching to CRE like 1
Attaching to CRE-like 1
cAMP responsive element binding protein 1
cAMP responsive element binding protein 3 like 4
cAMP responsive element binding protein 4
cAMP responsive element-binding protein 3 like protein 4
cAMP-responsive element-binding protein 3-like protein 4
cAMP-responsive element-binding protein 4
Cyclic AMP responsive element binding protein 3 like protein 4
Cyclic AMP responsive element binding protein 4
Cyclic AMP-responsive element-binding protein 4
Processed cyclic AMP-responsive element-binding protein 3-like protein 4
Transcript induced in spermiogenesis protein 40
功能Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements.
组织特异性According to PubMed:11830526, exclusively expressed in the prostate. Expressed in breast and prostate cancer cell lines. Expressed in prostatic luminal epithelial cells (at protein level). Expression is significantly more abundant in prostate cancer than in benign prostatic tissue (prostatic hyperplasia). According to PubMed:12111373, also expressed in brain, pancreas and skeletal muscle, and at lower levels in small intestine, testis, leukocyte and thymus.
序列相似性Belongs to the bZIP family. ATF subfamily. Contains 1 bZIP domain.
翻译后修饰N-glycosylated in the C-terminal region. Controlled by regulated intramembrane proteolysis (RIP). Following ER stress a fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site-1 and site-2 proteases (PS1 and PS2). PS1 cleavage may be suppressed by a determinant in the C-terminal region.
细胞定位Nucleus. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus and Endoplasmic reticulum membrane. Golgi apparatus membrane. May also be located in Golgi apparatus.