概述

描述

  • 性质Synthetic

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技术指标

Our Abpromise guarantee covers the use of ab41036 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-ADAMTS5 antibody (ab41037)

  • 形式Liquid
  • 补充说明

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

常规信息

  • 别名
    • A disintegrin and metalloproteinase with thrombospondin motifs 11
    • A disintegrin and metalloproteinase with thrombospondin motifs 5
    • A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif 5
    • A disintegrin like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase 2)
    • A Disintigrin And Metalloproteinase with ThromboSpondin motif-5
    • ADAM metallopeptidase with thrombospondin type 1 motif 5
    • ADAM TS 11
    • ADAM TS 5
    • ADAM TS5
    • ADAM-TS 11
    • ADAM-TS 5
    • ADAM-TS5
    • ADAMTS 11
    • ADAMTS 5
    • ADAMTS-11
    • ADAMTS-5
    • ADAMTS11
    • Adamts5
    • ADMP 2
    • ADMP-2
    • ADMP2
    • Aggrecanase 2
    • Aggrecanase-2
    • ATS5_HUMAN
    • FLJ36738
    • Implantin
    • ThromboSpondin motif-5
    see all
  • 功能Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period.
  • 组织特异性Expressed at low level in placenta primarily but also detected in heart and brain, cervix, uterus, bladder, esophagus, rib cartilage, chondroblastoma, fibrous tissue and a joint capsule from an arthritic patient.
  • 序列相似性Contains 1 disintegrin domain.
    Contains 1 peptidase M12B domain.
    Contains 2 TSP type-1 domains.
  • 结构域The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.
    The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.
  • 翻译后修饰The precursor is cleaved by a furin endopeptidase.
  • 细胞定位Secreted > extracellular space > extracellular matrix.
  • Information by UniProt

Human ADAMTS5 peptide (ab41036)参考文献

ab41036 has not yet been referenced specifically in any publications.

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