概述

描述

  • 性质Synthetic
  • 氨基酸序列
    • 种属Human

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技术指标

Our Abpromise guarantee covers the use of ab41847 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-AATF antibody (ab39631)

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

    Preservative: 0.02% Sodium Azide
    Constituents: 0.1% BSA, PBS, pH 7.2

常规信息

  • 别名
    • AATF
    • AATF_HUMAN
    • Apoptosis antagonizing transcription factor
    • Apoptosis-antagonizing transcription factor
    • CHE 1
    • CHE1
    • DED
    • Protein AATF
    • Rb binding protein Che 1
    • Rb-binding protein Che-1
    see all
  • 功能May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.
  • 组织特异性Ubiquitously expressed. Expressed at high levels in brain, heart, kidney, placenta and thymus.
  • 序列相似性Belongs to the AATF family.
  • 翻译后修饰Hyperphosphorylated during the G1/S phase transition.
  • 细胞定位Nucleus > nucleolus.
  • Information by UniProt

Human AATF peptide (ab41847)参考文献

ab41847 has not yet been referenced specifically in any publications.

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