概述

  • 产品名称Anti-HtrA2 / Omi抗体[E55]
    参阅全部 HtrA2 / Omi 一抗
  • 描述
    兔单克隆抗体[E55] to HtrA2 / Omi
  • 特异性ab32092 does not cross-react with other peptidase S1C family members.
  • 经测试应用适用于: WB, IHC-P, IPmore details
    不适用于: Flow Cyt or ICC
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to residues in the N-terminal of mature Human HtrA2/ Omi.

  • 阳性对照
    • Jurkat cell lysate.
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

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应用

Our Abpromise guarantee covers the use of ab32092 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Predicted molecular weight: 38 kDa.
IHC-P 1/250.
IP 1/40.
  • 应用说明Is unsuitable for Flow Cyt or ICC.
  • 靶标

    • 功能Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.
    • 组织特异性Isoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid.
    • 疾病相关Defects in HTRA2 are the cause of Parkinson disease type 13 (PARK13) [MIM:610297]. A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain.
    • 序列相似性Belongs to the peptidase S1B family.
      Contains 1 PDZ (DHR) domain.
    • 结构域The mature N-terminus is involved in the interaction with XIAP.
      The PDZ domain mediates interaction with MXI2.
    • 翻译后修饰Autoproteolytically activated.
    • 细胞定位Mitochondrion intermembrane space. Mitochondrion membrane. Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID.
    • Information by UniProt
    • 数据库链接
    • 别名
      • High temperature requirement protein A2 antibody
      • HTRA 2 antibody
      • HtrA like serine protease antibody
      • HtrA serine peptidase 2 antibody
      • HtrA, E. coli, homolog of, 2 antibody
      • HtrA2 antibody
      • HTRA2_HUMAN antibody
      • mitochondrial antibody
      • Omi stress regulated endoprotease antibody
      • Omi stress-regulated endoprotease antibody
      • PARK 13 antibody
      • PARK13 antibody
      • Protease serine 25 antibody
      • PRSS 25 antibody
      • PRSS25 antibody
      • Serine protease 25 antibody
      • Serine protease HTRA2 antibody
      • Serine protease HTRA2 mitochondrial antibody
      • Serine protease htra2 mitochondrial precursor antibody
      • Serine protease omi antibody
      • Serine proteinase OMI antibody
      see all

    Anti-HtrA2 / Omi antibody [E55] 图像

    • Anti-HtrA2 / Omi antibody [E55] (ab32092) at 1/2000 dilution + Jurkat cell lysate.

      Predicted band size : 38 kDa
      Observed band size : 38 kDa
    • ab32092 at a 1:250 dilution staining Htr2A/ Omi in human lung adenocarcinoma, using Immunohistochemistry, Paraffin Embedded Tissue.

    Anti-HtrA2 / Omi antibody [E55] (ab32092)参考文献

    This product has been referenced in:
    • Sosna J  et al. Differences and Similarities in TRAIL- and Tumor Necrosis Factor-Mediated Necroptotic Signaling in Cancer Cells. Mol Cell Biol 36:2626-44 (2016). Read more (PubMed: 27528614) »
    • Sosna J  et al. The proteases HtrA2/Omi and UCH-L1 regulate TNF-induced necroptosis. Cell Commun Signal 11:76 (2013). WB ; Human . Read more (PubMed: 24090154) »

    See all 7 Publications for this product

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