Anti-HtrA2 / Omi抗体(ab21307)

概述

  • 产品名称Anti-HtrA2 / Omi抗体
    参阅全部 HtrA2 / Omi 一抗
  • 描述
    兔多克隆抗体to HtrA2 / Omi
  • 经测试应用适用于: ICC/IF, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide corresponding to Human HtrA2/ Omi.

应用

Our Abpromise guarantee covers the use of ab21307 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 0.5 - 1 µg/ml. Predicted molecular weight: 48 kDa.

靶标

  • 功能Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Cleaves THAP5 and promotes its degradation during apoptosis. Isoform 2 seems to be proteolytically inactive.
  • 组织特异性Isoform 1 is ubiquitous. Isoform 2 is expressed predominantly in the kidney, colon and thyroid.
  • 疾病相关Defects in HTRA2 are the cause of Parkinson disease type 13 (PARK13) [MIM:610297]. A complex neurodegenerative disorder characterized by bradykinesia, resting tremor, muscular rigidity and postural instability, as well as by a clinically significant response to treatment with levodopa. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain.
  • 序列相似性Belongs to the peptidase S1B family.
    Contains 1 PDZ (DHR) domain.
  • 结构域The mature N-terminus is involved in the interaction with XIAP.
    The PDZ domain mediates interaction with MXI2.
  • 翻译后修饰Autoproteolytically activated.
  • 细胞定位Mitochondrion intermembrane space. Mitochondrion membrane. Predominantly present in the intermembrane space. Released into the cytosol following apoptotic stimuli, such as UV treatment, and stimulation of mitochondria with caspase-8 truncated BID/tBID.
  • Information by UniProt
  • 数据库链接
  • 别名
    • High temperature requirement protein A2 antibody
    • HTRA 2 antibody
    • HtrA like serine protease antibody
    • HtrA serine peptidase 2 antibody
    • HtrA, E. coli, homolog of, 2 antibody
    • HtrA2 antibody
    • HTRA2_HUMAN antibody
    • mitochondrial antibody
    • Omi stress regulated endoprotease antibody
    • Omi stress-regulated endoprotease antibody
    • PARK 13 antibody
    • PARK13 antibody
    • Protease serine 25 antibody
    • PRSS 25 antibody
    • PRSS25 antibody
    • Serine protease 25 antibody
    • Serine protease HTRA2 antibody
    • Serine protease HTRA2 mitochondrial antibody
    • Serine protease htra2 mitochondrial precursor antibody
    • Serine protease omi antibody
    • Serine proteinase OMI antibody
    see all

Anti-HtrA2 / Omi antibody 图像

  • Immunofluorescence of HtrA2 / Omi in Human colon tissue with ab21307 at 20 ug/mL.

  • Lane 1 : Anti-HtrA2 / Omi antibody (ab21307) at 0.5 µg/ml
    Lane 2 : Anti-HtrA2 / Omi antibody (ab21307) at 1 µg/ml

    Lane 1 : Human colon cell lysate
    Lane 2 : Human colon cell lysate


    Predicted band size : 48 kDa
    Western blot analysis of HtrA2 in human colon cell lysates with anti-HtrA2 at (A) 0.5 and (B) 1 µg/ml.

Anti-HtrA2 / Omi antibody (ab21307)参考文献

ab21307 has not yet been referenced specifically in any publications.

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