概述

  • 产品名称Anti-HSP90B2P抗体
  • 描述
    兔多克隆抗体to HSP90B2P
  • 经测试应用适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Rat, Chicken, Human, Drosophila melanogaster, Monkey
    预测可用于: Rabbit, Cow, Dog, Pig, Xenopus laevis, Zebrafish, Cynomolgus Monkey, Syrian Hamster, Orangutan
  • 免疫原

    Synthetic peptide corresponding to Human HSP90B2P aa 289-300 (C terminal).
    Sequence:

    SQYGWSGNMERI

  • 阳性对照
    • Human kidney tissue.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.01% Sodium Azide
    Constituents: 0.15M Sodium chloride, 0.02M Potassium phosphate, pH 7.2
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab64182 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/2500. Predicted molecular weight: 46 kDa.
ELISA 1/5000 - 1/25000.
IHC-P Use a concentration of 2.5 µg/ml.

靶标

  • 相关性Hsp90 is a member of the heat shock protein 90 family that functions as a molecular chaperone and has ATPase activity. Hsp90 family proteins are highly conserved between isoforms and species. Several signal transduction pathways depend on Hsp90 function including erbB2, steroid hormone receptors (such as androgen, progesterone, glucocorticoid, and aryl-hydrocarbon), and hypoxia sensing (Hif1alpha). Recent reports show that tumor cells are more sensitive to Hsp90 inhibition and that Hsp90 from tumor cells is more sensitive to small molecule inhibitors (eg 17AAG). The mechanism of this differential sensitivity of normal versus tumor Hsp90 is not known (although mutation has been ruled out). One possible mechanism may be differences in post-translational modification of tumor Hsp90. Hsp90 is a cytoplasmic protein that forms a homodimer in vivo, and interacts with TOM34, AHSA1, HDAC6 and SMYD3.
  • 细胞定位Endoplasmic reticulum
  • 数据库链接
  • 别名
    • GRP94P1 antibody
    • Heat shock protein 90kDa beta (Grp94) member 2 antibody
    • HSP antibody
    • HSPCP2 antibody
    • Putative endoplasmin like protein antibody
    • Putative heat shock protein 90 kDa beta member 2 antibody
    • TRA1P1 antibody
    • TRAP1 antibody
    see all

Anti-HSP90B2P antibody 图像

  • ab64182 (2.5ug/ml) staining HSP90B2P in human kidney tissue by immunohistochemistry using formalin-fixed, paraffin-embedded tissue.

Anti-HSP90B2P antibody (ab64182)参考文献

ab64182 has not yet been referenced specifically in any publications.

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