概述

  • 产品名称Anti-Hsp60抗体[LK 1]
    参阅全部 Hsp60 一抗
  • 描述
    小鼠单克隆抗体[LK 1] to Hsp60
  • 特异性This antibody is specific to the 60 kDa protein, HSP60. This antibody recognizes only mammalian HSP60 and not bacterial HSP60.
  • 经测试应用适用于: ICC/IF, IHC-P, IHC-Fr, IP, WBmore details
  • 种属反应性
    与反应: Rat, Chicken, Hamster, Human
    不与反应: Escherichia coli
  • 免疫原

    BALB/C mice were injected with recombinant HSP 60 protein.

  • 阳性对照
    • Breast carcinoma

性能

应用

Our Abpromise guarantee covers the use of ab1819 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use at an assay dependent concentration.
IHC-P 1/25 - 1/75. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. PubMed: 16947118ABC method.
IHC-Fr 1/25 - 1/75. ABC method.
IP Use at an assay dependent concentration.
WB Use at an assay dependent concentration.

靶标

  • 功能Implicated in mitochondrial protein import and macromolecular assembly. May facilitate the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix.
  • 疾病相关Defects in HSPD1 are a cause of spastic paraplegia autosomal dominant type 13 (SPG13) [MIM:605280]. Spastic paraplegia is a degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs.
    Defects in HSPD1 are the cause of leukodystrophy hypomyelinating type 4 (HLD4) [MIM:612233]; also called mitochondrial HSP60 chaperonopathy or MitCHAP-60 disease. HLD4 is a severe autosomal recessive hypomyelinating leukodystrophy. Clinically characterized by infantile-onset rotary nystagmus, progressive spastic paraplegia, neurologic regression, motor impairment, profound mental retardation. Death usually occurrs within the first two decades of life.
  • 序列相似性Belongs to the chaperonin (HSP60) family.
  • 细胞定位Mitochondrion matrix.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 60 kDa chaperonin antibody
    • 60 kDa heat shock protein, mitochondrial antibody
    • CH60_HUMAN antibody
    • Chaperonin 60 antibody
    • Chaperonin, 60-KD antibody
    • CPN60 antibody
    • fa04a05 antibody
    • GROEL antibody
    • heat shock 60kDa protein 1 (chaperonin) antibody
    • Heat shock protein 1 (chaperonin) antibody
    • Heat shock protein 60 antibody
    • Heat shock protein 65 antibody
    • heat shock protein family D (Hsp60) member 1 antibody
    • HLD4 antibody
    • Hsp 60 antibody
    • HSP 65 antibody
    • HSP-60 antibody
    • HSP60 antibody
    • HSP65 antibody
    • HSPD1 antibody
    • HuCHA60 antibody
    • Mitochondrial matrix protein P1 antibody
    • P60 lymphocyte protein antibody
    • short heat shock protein 60 Hsp60s1 antibody
    • SPG13 antibody
    see all

Anti-Hsp60 antibody [LK 1] 图像

  • ab1819 staining human breast carcinoma by IHC-P.

Anti-Hsp60 antibody [LK 1] (ab1819)参考文献

This product has been referenced in:
  • Bellingham M  et al. Exposure to chemical cocktails before or after conception - the effect of timing on ovarian development. Mol Cell Endocrinol 376:156-72 (2013). IHC . Read more (PubMed: 23791816) »
  • Fowler PA  et al. Gene expression analysis of human fetal ovarian primordial follicle formation. J Clin Endocrinol Metab 94:1427-35 (2009). Read more (PubMed: 19258411) »

See all 4 Publications for this product

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approx. 100 ug/ml

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"