概述

  • 产品名称Anti-HSF4抗体
    参阅全部 HSF4 一抗
  • 描述
    兔多克隆抗体to HSF4
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region between N terminal amino acids 99-128 of Human HSF4 (NP_001529.2, NP_001035757.1).

  • 阳性对照
    • HL60 cell line lysates

性能

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应用

Our Abpromise guarantee covers the use of ab124111 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 53 kDa.

靶标

  • 功能DNA-binding protein that specifically binds heat shock promoter elements (HSE). Isoform HSF4A represses transcription while the isoform HSF4B activates transcription.
  • 组织特异性Expressed in heart, skeletal muscle, eye and brain, and at much lower levels in some other tissues.
  • 疾病相关Defects in HSF4 are the cause of cataract zonular HSF4-related (CZ-HSF4) [MIM:116800]. A form of zonular cataract. Zonular or lamellar cataracts are opacities, broad or narrow, usually consisting of powdery white dots affecting only certain layers or zones between the cortex and nucleus of an otherwise clear lens. The opacity may be so dense as to render the entire central region of the lens completely opaque, or so translucent that vision is hardly if at all impeded. Zonular cataracts generally do not involve the embryonic nucleus, though sometimes they involve the fetal nucleus. Usually sharply separated from a clear cortex outside them, they may have projections from their outer edges known as riders or spokes.
    Defects in HSF4 are the cause of cataract Marner type (CAM) [MIM:116800]. A form of cataract with variable and progressive opacities. Affected individuals present with zonular cataract, although some have nuclear, anterior polar, or stellate cataract. Finger malformation is observed in some kindreds.
  • 序列相似性Belongs to the HSF family.
  • 翻译后修饰Phosphorylated mainly on serine residues. Phosphorylation on Ser-298 promotes sumoylation on Lys-293.
    Isoform HSF4B is constitutively sumoylated. Sumoylation represses the transcriptional activity and is promoted by phosphorylation on Ser-298. HSFA is not sumoylated.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Cataract, Marner antibody
    • CTM antibody
    • Heat shock factor protein 4 antibody
    • Heat shock transcription factor 4 antibody
    • hHSF4 antibody
    • HSF 4 antibody
    • HSF4 antibody
    • HSF4_HUMAN antibody
    • HSTF 4 antibody
    see all

Anti-HSF4 antibody 图像

  • Anti-HSF4 antibody (ab124111) at 1/100 dilution + HL60 cell line lysates at 35 µg

    Predicted band size : 53 kDa

Anti-HSF4 antibody (ab124111)参考文献

ab124111 has not yet been referenced specifically in any publications.

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