概述

  • 产品名称Anti-HSD3a抗体
    参阅全部 HSD3a 一抗
  • 描述
    山羊多克隆抗体to HSD3a
  • 特异性This antibody may cross-react with AKR1C1.
  • 经测试应用适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Cynomolgus Monkey, Macaque Monkey
  • 免疫原

    Synthetic peptide:

    C-DPKYQRVELNDGH

    , corresponding to N terminal amino acids 2-14 of Human HSD3a

  • 阳性对照
    • Human Liver lysate.

性能

应用

Our Abpromise guarantee covers the use of ab50415 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 35 kDa (predicted molecular weight: 37 kDa).
ELISA Use at an assay dependent dilution.
IHC-P Use a concentration of 2 - 4 µg/ml.

靶标

  • 功能Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol). Also has some 20-alpha-hydroxysteroid dehydrogenase activity. The biotransformation of the pesticide chlordecone (kepone) to its corresponding alcohol leads to increased biliary excretion of the pesticide and concomitant reduction of its neurotoxicity since bile is the major excretory route.
  • 组织特异性Liver specific.
  • 序列相似性Belongs to the aldo/keto reductase family.
  • 翻译后修饰The N-terminus is blocked.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 3 alpha HSD1 antibody
    • 3-alpha-HSD1 antibody
    • 3-alpha-hydroxysteroid dehydrogenase type I antibody
    • AK1C4_HUMAN antibody
    • AKR1C4 antibody
    • Aldo keto reductase family 1 member C4 antibody
    • Aldo-keto reductase family 1 member C4 antibody
    • CDR antibody
    • Chlordecone reductase antibody
    • DD-4 antibody
    • DD4 antibody
    • Dihydrodiol dehydrogenase 4 antibody
    • HAKRA antibody
    see all

Anti-HSD3a antibody 图像

  • Anti-HSD3a antibody (ab50415) at 0.1 µg/ml + Human Liver lysate (35µg protein in RIPA buffer).

    Predicted band size : 37 kDa
    Observed band size : 35 kDa (why is the actual band size different from the predicted?)
  • ab50415 at 4µg/ml staining HSD3a in Human liver tissue section by Immunohistochemistry (Formalin/ PFA-fixed paraffin-embedded tissue sections). The tissue underwent antigen retrieval by steam in citrate buffer pH 6.0.

Anti-HSD3a antibody (ab50415)参考文献

ab50415 has not yet been referenced specifically in any publications.

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