概述

  • 产品名称
    Anti-HSD17B7抗体
  • 描述
    兔多克隆抗体to HSD17B7
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Recombinant fragment, corresponding to amino acids 35-221 of Human HSD17B7 (BC007068).

  • 阳性对照
    • 293T and MCF7 cell lysates.

性能

应用

Our Abpromise guarantee covers the use of ab112006 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 33 kDa (predicted molecular weight: 38 kDa).

靶标

  • 功能
    Responsible for the reduction of the keto group on the C-3 of sterols.
  • 组织特异性
    Highly expressed in adrenal gland, liver, lung and thymus. Expressed in breast, ovaries, pituitary gland, pregnant uterus, prostate, kidney, lymph node, small intestine, spinal cord and trachea. Weakly expressed in all other tissues tested. Isoform 3 is expressed in eye ciliary epithelial cells and neuroendocrine cells.
  • 通路
    Steroid biosynthesis; estrogen biosynthesis.
    Steroid biosynthesis; zymosterol biosynthesis; zymosterol from lanosterol: step 5/6.
  • 序列相似性
    Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.
  • 翻译后修饰
    Phosphorylated.
  • 细胞定位
    Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 17 beta HSD 7 antibody
    • 17 beta hydroxysteroid dehydrogenase 7 antibody
    • 17 beta hydroxysteroid dehydrogenase type VII antibody
    • 17-beta-HSD 7 antibody
    • 17-beta-hydroxysteroid dehydrogenase 7 antibody
    • 17beta hydroxysteroid dehydrogenase antibody
    • 3 keto steroid reductase antibody
    • 3-keto-steroid reductase antibody
    • DHB7_HUMAN antibody
    • Estradiol 17 beta dehydrogenase 7 antibody
    • Estradiol 17-beta-dehydrogenase 7 antibody
    • Hsd17b7 antibody
    • Hydroxysteroid (17 beta) dehydrogenase 7 antibody
    • MGC12523 antibody
    • MGC75018 antibody
    • PRAP antibody
    • SDR37C1 antibody
    • Short chain dehydrogenase/reductase family 37C member 1 antibody
    see all

图片

  • All lanes : Anti-HSD17B7 antibody (ab112006) at 1/500 dilution

    Lane 1 : 293T cell lysate
    Lane 2 : MCF7 cell lysate


    Predicted band size : 38 kDa

实验方案

文献

This product has been referenced in:
  • Wang X  et al. Synergistic control of sex hormones by 17ß-HSD type 7: a novel target for estrogen-dependent breast cancer. J Mol Cell Biol 7:568-79 (2015). Read more (PubMed: 25966904) »

See 1 Publication for this product

客户评价及客户问答

There are currently no Customer reviews or Questions for ab112006.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

注册