概述

  • 产品名称Anti-HSD17B12抗体
    参阅全部 HSD17B12 一抗
  • 描述
    小鼠单克隆抗体to HSD17B12
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human, Recombinant Fragment
    预测可用于: Rat, Cow, Pig, Cynomolgus Monkey
  • 免疫原

    Recombinant fragment: SATKTFVDFF SQCLHEEYRS KGVFVQSVLP YFVATKLAKI RKPTLDKPSP ETFVKSAIKT VGLQSRTNG, corresponding to amino acids 203-272 of Human HSD17B12, with a 26 kDa tag. NP_057226

  • 阳性对照
    • Jurkat cell lysate.

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab88133 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 34 kDa.
ELISA Use at an assay dependent dilution.

靶标

  • 功能Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation.
  • 组织特异性Expressed in most tissues tested. Highly expressed in the ovary and mammary. Expressed in platelets.
  • 通路Steroid biosynthesis; estrogen biosynthesis.
    Lipid metabolism; fatty acid biosynthesis.
  • 序列相似性Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
  • 结构域The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.
  • 细胞定位Endoplasmic reticulum membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 12,3-ketoacyl-CoA reductase,short chain antibody
    • 17 beta HSD 12 antibody
    • 17 beta hydroxysteroid dehydrogenase 12 antibody
    • 17-@beta-HSD XII antibody
    • 17-@beta-hydroxysteroid dehydrogenase XII antibody
    • 17-beta-HSD 12 antibody
    • 17-beta-hydroxysteroid dehydrogenase 12 antibody
    • 17beta HSD type 12 antibody
    • 3 ketoacyl CoA reductase antibody
    • 3-ketoacyl-CoA reductase antibody
    • DHB12_HUMAN antibody
    • Estradiol 17 beta dehydrogenase 12 antibody
    • Estradiol 17-beta-dehydrogenase 12 antibody
    • HSD17B12 antibody
    • Hydroxysteroid (17-beta) dehydrogenase 12 antibody
    • KAR antibody
    • KIK-I antibody
    • Kik1 antibody
    • SDR12C1 antibody
    • Short chain dehydrogenase/reductase family 12C member 1 antibody
    • Steroid dehydrogenase homolog antibody
    see all

Anti-HSD17B12 antibody 图像

  • Anti-HSD17B12 antibody (ab88133) at 1/500 dilution + Jurkat cell lysate at 25 µg

    Secondary
    Goat anti-mouse IgG (H&L)-HRP conjugate at 1/2500 dilution

    Predicted band size : 34 kDa
    Observed band size : 30 kDa (why is the actual band size different from the predicted?)

Anti-HSD17B12 antibody (ab88133)参考文献

ab88133 has not yet been referenced specifically in any publications.

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