Synthetic peptide corresponding to Human HSD17B12 (internal sequence) conjugated to Keyhole Limpet Haemocyanin (KLH).
A2058 cell line lysates, Human hepatocarcinoma tissue.
Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
Preservative: 0.09% Sodium Azide
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Immunogen affinity purified
ab103107 is purified through a protein A column, followed by peptide affinity purification.
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in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/100 - 1/500. Predicted molecular weight: 34 kDa.
1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation.
Expressed in most tissues tested. Highly expressed in the ovary and mammary. Expressed in platelets.
Steroid biosynthesis; estrogen biosynthesis.
Lipid metabolism; fatty acid biosynthesis.
Belongs to the short-chain dehydrogenases/reductases (SDR) family. 17-beta-HSD 3 subfamily.
The di-lysine motif confers endoplasmic reticulum localization for type I membrane proteins.
Endoplasmic reticulum membrane.
Information by UniProt
12,3-ketoacyl-CoA reductase,short chain antibody
17 beta HSD 12 antibody
17 beta hydroxysteroid dehydrogenase 12 antibody
Western blot - Anti-HSD17B12 antibody (ab103107)
Anti-HSD17B12 antibody (ab103107) at 1/100 dilution + A2058 cell line lysates at 35 µg
Predicted band size: 34 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HSD17B12 antibody (ab103107)
ab103107 at 1/50 dilution staining HSD17B12 in Human hepatocarcinoma by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining
has not yet been referenced specifically in any publications.
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