概述

  • 产品名称Anti-HSD11B2抗体
    参阅全部 HSD11B2 一抗
  • 描述
    小鼠多克隆抗体to HSD11B2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length human HSD11B2 protein (AAH64536.1).

  • 阳性对照
    • Human colon tissue lysate and HSD11B2 transfected 293T cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab89669 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 44 kDa.

靶标

  • 功能Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.
  • 组织特异性Found in placenta, kidney, pancreas, prostate, ovary, small intestine and colon.
  • 疾病相关Defects in HSD11B2 are the cause of apparent mineralocorticoid excess (AME) [MIM:218030]. AME is a potentially fatal disease characterized by severe juvenile low-renin hypertension, sodium retention, hypokalemia and low levels of aldosterone. It often leads to nephrocalcinosis.
  • 序列相似性Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • 细胞定位Microsome. Endoplasmic reticulum.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 11 beta HSD2 antibody
    • 11 beta hydroxysteroid dehydrogenase type 2 antibody
    • 11 DH2 antibody
    • 11-beta-HSD2 antibody
    • 11-beta-hydroxysteroid dehydrogenase type 2 antibody
    • 11-DH2 antibody
    • AME antibody
    • AME1 antibody
    • Corticosteroid 11 beta dehydrogenase isozyme 2 antibody
    • Corticosteroid 11-beta-dehydrogenase isozyme 2 antibody
    • DHI2_HUMAN antibody
    • HSD11B2 antibody
    • HSD11K antibody
    • HSD2 antibody
    • Hydroxysteroid 11 beta dehydrogenase 2 antibody
    • Hydroxysteroid 11 beta dehydrogenase isoenzyme 2 antibody
    • NAD dependent 11 beta hydroxysteroid dehydrogenase antibody
    • NAD-dependent 11-beta-hydroxysteroid dehydrogenase antibody
    • SDR9C3 antibody
    • Short chain dehydrogenase/reductase family 9C, member 3 antibody
    see all

Anti-HSD11B2 antibody 图像

  • Anti-HSD11B2 antibody (ab89669) at 1 µg/ml + human colon tissue lysate at 50 µg

    Predicted band size : 44 kDa
    Observed band size : 37 kDa (why is the actual band size different from the predicted?)
  • All lanes : Anti-HSD11B2 antibody (ab89669) at 1 µg/ml

    Lane 1 : HSD11B2 transfected 293T cell lysate
    Lane 2 : Non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.


    Predicted band size : 44 kDa
    Observed band size : 41 kDa (why is the actual band size different from the predicted?)

Anti-HSD11B2 antibody (ab89669)参考文献

ab89669 has not yet been referenced specifically in any publications.

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