• 产品名称Anti-HSD11B1抗体
    参阅全部 HSD11B1 一抗
  • 描述
    兔多克隆抗体to HSD11B1
  • 经测试应用适用于: WB, IHC-P, IHC-Fr, ICCmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
    预测可用于: Rabbit, Dog, Pig, Cynomolgus Monkey
  • 免疫原

    Synthetic peptide:


    , corresponding to internal sequence amino acids 131-145 of Human HSD11B1.

  • 阳性对照
    • HeLa cell lysate, SMMC cell lysate, Raji cell lysate, Colo320 cell lysate.



Our Abpromise guarantee covers the use of ab109554 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 32 kDa.
IHC-P Use a concentration of 1 µg/ml.
IHC-Fr Use a concentration of 1 µg/ml.
ICC Use a concentration of 1 µg/ml.


  • 功能Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol.
  • 组织特异性Widely expressed. Highest expression in liver.
  • 疾病相关Defects in HSD11B1 are a cause of cortisone reductase deficiency (CRD) [MIM:604931]. In CRD, activation of cortisone to cortisol does not occur, resulting in adrenocorticotropin-mediated androgen excess and a phenotype resembling polycystic ovary syndrome (PCOS).
  • 序列相似性Belongs to the short-chain dehydrogenases/reductases (SDR) family.
  • 翻译后修饰Glycosylated.
  • 细胞定位Endoplasmic reticulum membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 11 beta HSD 1 antibody
    • 11 beta HSD1 antibody
    • 11 beta hydroxysteroid dehydrogenase 1 antibody
    • 11 DH antibody
    • 11-beta hydroxysteroid dehydrogenase, type 1 antibody
    • 11-beta-HSD1 antibody
    • 11-beta-hydroxysteroid dehydrogenase 1 antibody
    • 11-DH antibody
    • 11DH antibody
    • Corticosteroid 11 beta dehydrogenase isozyme 1 antibody
    • Corticosteroid 11-beta-dehydrogenase isozyme 1 antibody
    • CORTRD2 antibody
    • DHI1_HUMAN antibody
    • HDL antibody
    • HSD 11 antibody
    • HSD11 antibody
    • HSD11B antibody
    • HSD11B1 antibody
    • HSD11L antibody
    • Hydroxysteroid (11 beta) dehydrogenase antibody
    • Hydroxysteroid (11 beta) dehydrogenase 1 antibody
    • MGC13539 antibody
    • SDR26C1 antibody
    • short chain dehydrogenase/reductase family 26C, member 1 antibody
    see all

Anti-HSD11B1 antibody 图像

  • All lanes : Anti-HSD11B1 antibody (ab109554) at 1 µg/ml

    Lane 1 : HeLa whole cell lysate
    Lane 2 : SMMC whole cell lysate
    Lane 3 : Raji whole cell lysate
    Lane 4 : Colo320 whole cell lysate

    Predicted band size : 32 kDa

Anti-HSD11B1 antibody (ab109554)参考文献

ab109554 has not yet been referenced specifically in any publications.

Product Wall

Abcam guarantees this product to work in the species/application used in this Abreview.
Application Western blot
Sample Human Cell lysate - whole cell (HK2 cell (human kidney proximal tubule))
Loading amount 30 µg
Specification HK2 cell (human kidney proximal tubule)
Gel Running Conditions Reduced Denaturing (12)
Blocking step Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 7% · Temperature: 20°C

Mr. Dongil Kim

Verified customer

提交于 May 03 2013

Thank you for confirming these details and for your cooperation. The details provided enable us to closely monitor the quality of our products. I am sorry for any inconvenience that this product has caused. As requested, I have issued a free of char...

Read More

Thank you for confirming these details and for your cooperation. The details provided enable us to closely monitor the quality of our products.

I am sorry this product did not perform as stated on the datasheet and for the inconvenience this...

Read More