概述

  • 产品名称Anti-HRH3抗体
    参阅全部 HRH3 一抗
  • 描述
    兔多克隆抗体to HRH3
  • 经测试应用适用于: WB, IPmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rat, Rhesus monkey
  • 免疫原

    Synthetic peptide: designeds within amino acids 257-287 of Human HRH3

  • 阳性对照
    • Jurkat

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab84468 is purified through a protein A column, followed by peptide affinity purification.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab84468 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/100 - 1/500. Predicted molecular weight: 49 kDa.
IP Use at an assay dependent concentration. PubMed: 24566390

靶标

  • 功能The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 niether modified adenylate cyclase activity nor induced intracellular calcium mobilization.
  • 组织特异性Expressed predominantly in the CNS, with the greatest expression in the thalamus and caudate nucleus. The various isoforms are mainly coexpressed in brain, but their relative expression level varies in a region-specific manner. Isoform 3 and isoform 7 are highly expressed in the thalamus, caudate nucleus and cerebellum while isoform 5 and isoform 6 show a poor expression. Isoform 5 and isoform 6 show a high expression in the amygdala, substantia nigra, cerebral cortex and hypothalamus. Isoform 7 is not found in hypothalamus or substantia nigra.
  • 序列相似性Belongs to the G-protein coupled receptor 1 family.
  • 细胞定位Cell membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • G protein coupled receptor 97 antibody
    • G-protein coupled receptor 97 antibody
    • GPCR 97 antibody
    • GPCR97 antibody
    • H3R antibody
    • HH 3R antibody
    • HH3 R antibody
    • HH3R antibody
    • Histamine H3 receptor antibody
    • Histamine receptor H3 antibody
    • HRH 3 antibody
    • HRH3 antibody
    • HRH3_HUMAN antibody
    • OTTHUMP00000031459 antibody
    see all

Anti-HRH3 antibody 图像

  • Anti-HRH3 antibody (ab84468) at 1/500 dilution + 35µg of Jurkat whole cell lysate

    Predicted band size : 49 kDa
    Observed band size : 49 kDa
    Additional bands at : 32 kDa. We are unsure as to the identity of these extra bands.

Anti-HRH3 antibody (ab84468)参考文献

This product has been referenced in:
  • Yan H  et al. Histamine H3 receptors aggravate cerebral ischaemic injury by histamine-independent mechanisms. Nat Commun 5:3334 (2014). WB, IP ; Mouse . Read more (PubMed: 24566390) »

See 1 Publication for this product

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