Anti-HRG beta 1抗体(Biotin) (ab87549)

概述

  • 产品名称Anti-HRG beta 1抗体(Biotin)
    参阅全部 HRG beta 1 一抗
  • 描述
    兔多克隆抗体to HRG beta 1 (Biotin)
  • 偶联物Biotin
  • 经测试应用适用于: ELISA, Sandwich ELISA, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant Human HRG beta 1.

性能

  • 形式Lyophilised:Centrifuge vial prior to opening. Reconstitute in sterile PBS containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml.
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: None
    Constituents: PBS, pH 7.2
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab87549 was purified by affinity chromatography and then biotinylated.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

相关产品

应用

Our Abpromise guarantee covers the use of ab87549 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use a concentration of 0.25 - 1 µg/ml. (using 100 µl/well antibody solution). ab87549 in conjunction with compatible secondary reagents, allows the detection of at least 0.2 - 0.4 ng/well of recombinant human HRG beta 1.
Sandwich ELISA Use a concentration of 0.25 - 1 µg/ml. Can be paired for Sandwich ELISA with Rabbit polyclonal to HRG beta 1 (ab87547). When used as detection antibody when paired with recommended antibody, allows detection at least 0.2 - 0.4 ng/well of recombinant human HRG beta 1(using 100 µl/well antibody solution).
WB Use a concentration of 0.1 - 0.2 µg/ml. Predicted molecular weight: 70 kDa. Used in conjunction with compatible secondary reagents the detection limit for recombinant human HRG beta 1 is 1.5 - 3.0 ng/lane, under either reducing or non-reducing conditions.

靶标

  • 相关性HRG beta 1 is an isoform from the Neuregulin/Heregulin family of structurally related polypeptide growth factors which are derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentialtion of epithelial, neuronal, glial, and other types of cells. HRG1-ß1 contains an Ig domain and an EGF-like domain that is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. Although HRG1-ß1 biological effects are still unclear, it has been found to promote motility and invasiveness of breast cancer cells which may also involve up-regulation of expression and function of the autocrine motility promoting factor (AMF).
  • 细胞定位Secreted
  • 数据库链接
  • 别名
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Anti-HRG beta 1 antibody (Biotin) (ab87549)参考文献

ab87549 has not yet been referenced specifically in any publications.

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