Anti-HRG beta 1抗体(ab87547)
Key features and details
- Rabbit polyclonal to HRG beta 1
- Suitable for: IHC-P, Sandwich ELISA, WB
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-HRG beta 1抗体 -
描述
兔多克隆抗体to HRG beta 1 -
宿主
Rabbit -
经测试应用
适用于: IHC-P, Sandwich ELISA, WBmore details -
种属反应性
与反应: Human -
免疫原
Recombinant Human HRG beta 1.
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常规说明
Although some customers have been successful in IHC we no longer batch test in this application.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Lyophilized:Reconstitute in sterile water to a concentration of 0.1-1.0 mg/ml. -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
存储溶液
Constituent: PBS -
Concentration information loading...
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纯度
Immunogen affinity purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab87547于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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IHC-P |
Use at an assay dependent concentration.
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Sandwich ELISA |
Use at an assay dependent concentration.
Allows the detection of at least 0.2 - 0.4 ng/well of recombinant human HRG beta 1. Can be used as capture antibody when paired with ab87549. |
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WB | (1) |
Use at an assay dependent concentration.
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说明 |
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IHC-P
Use at an assay dependent concentration. |
Sandwich ELISA
Use at an assay dependent concentration. Allows the detection of at least 0.2 - 0.4 ng/well of recombinant human HRG beta 1. Can be used as capture antibody when paired with ab87549. |
WB
Use at an assay dependent concentration. |
靶标
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相关性
HRG beta 1 is an isoform from the Neuregulin/Heregulin family of structurally related polypeptide growth factors which are derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. The receptors for all NRG1 isoforms are the ERBB family of tyrosine kinase transmembrane receptors. Through interaction with ERBB receptors, NRG1 isoforms induce the growth and differentialtion of epithelial, neuronal, glial, and other types of cells. HRG1-ß1 contains an Ig domain and an EGF-like domain that is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. Although HRG1-ß1 biological effects are still unclear, it has been found to promote motility and invasiveness of breast cancer cells which may also involve up-regulation of expression and function of the autocrine motility promoting factor (AMF). -
细胞定位
Secreted -
数据库链接
- Entrez Gene: 3084 Human
- Omim: 142445 Human
- SwissProt: Q02297 Human
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别名
- Acetylcholine receptor inducing activity antibody
- ARIA antibody
- Breast cancer cell differentiation factor p45 antibody
see all
数据表及文件
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Datasheet download
文献 (1)
ab87547 被引用在 1 文献中.
- Jiao L et al. Nuclear factor-kappa B activation inhibits proliferation and promotes apoptosis of vascular smooth muscle cells. Vascular 26:634-640 (2018). PubMed: 30003828