This fast track antibody is not yet fully characterized. It is subject to these terms and conditions




  • 应用说明WB: 1/250. Detects a band of approximately >250 kDa (predicted molecular weight: 121 kDa).

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles.
    • 组织特异性Ubiquitously expressed.
    • 疾病相关Defects in AP3B1 are the cause of Hermansky-Pudlak syndrome type 2 (HPS2) [MIM:608233]. Hermansky-Pudlak syndrome (HPS) is a genetically heterogeneous, rare, autosomal recessive disorder characterized by oculocutaneous albinism, bleeding due to platelet storage pool deficiency, and lysosomal storage defects. This syndrome results from defects of diverse cytoplasmic organelles including melanosomes, platelet dense granules and lysosomes. Ceroid storage in the lungs is associated with pulmonary fibrosis, a common cause of premature death in individuals with HPS. HPS2 differs from the other forms of HPS in that it includes immunodeficiency in its phenotype and patients with HPS2 have an increased susceptibility to infections.
    • 序列相似性Belongs to the adaptor complexes large subunit family.
    • 翻译后修饰Phosphorylated on serine residues.
    • 细胞定位Golgi apparatus. Cytoplasmic vesicle > clathrin-coated vesicle membrane. Golgi apparatus. Component of the coat surrounding the cytoplasmic face of coated vesicles located at the Golgi complex.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Adapter related protein complex 3 beta 1 subunit antibody
      • Adapter-related protein complex 3 subunit beta-1 antibody
      • Adaptor protein complex AP-3 subunit beta-1 antibody
      • Adaptor protein complex AP3 beta1 subunit antibody
      • ADTB3 antibody
      • ADTB3A antibody
      • AP-3 complex subunit beta-1 antibody
      • AP3 complex beta1 subunit antibody
      • AP3B1 antibody
      • AP3B1_HUMAN antibody
      • Beta-3A-adaptin antibody
      • Beta3A adaptin antibody
      • Clathrin assembly protein complex 3 beta 1 large chain antibody
      • Clathrin assembly protein complex 3 beta-1 large chain antibody
      • HPS antibody
      • PE antibody
      see all

    Anti-HPS2 antibody 图像

    This Fast-Track antibody is not yet fully characterised. These images represent inconclusive preliminary data.

    • All lanes : Anti-HPS2 antibody (ab71169) at 1/250 dilution

      Lane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate
      Lane 2 : Rat Thymus Tissue Lysate
      Lane 3 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell Lysate
      Lane 4 : Liver (Mouse) Tissue Lysate
      Lane 5 : Human placenta tissue lysate - total protein (ab29745)

      Lysates/proteins at 10 µg per lane.

      Goat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilution

      Performed under reducing conditions.

      Observed band size : >250 kDa (why is the actual band size different from the predicted?)
      Additional bands at : 37 kDa. We are unsure as to the identity of these extra bands.

      Exposure time : 5 minutes

    Anti-HPS2 antibody (ab71169)参考文献

    ab71169 has not yet been referenced specifically in any publications.

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