Anti-HPRT抗体(ab97698)

概述

• 产品名称
  Anti-HPRT抗体
  参阅全部 HPRT 一抗
• 描述
  兔多克隆抗体to HPRT
• 经测试应用
  适用于: WBmore details
• 种属反应性
  与反应: Human
  预测可用于: Mouse, Rat, Rabbit, Cow, Dog, Pig, Zebrafish
• 免疫原

  Recombinant fragment, corresponding to amino acids 1-173 of Human HPRT (NP_000185).

• 阳性对照
  • IMR32 whole cell lysate; A549 and HCT116 cell lysates.

性能

• 形式
  Liquid
• 存放说明
  Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
• 存储溶液
  Preservative: 0.01% Thimerosal (merthiolate)
  Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
• Concentration information loading...
• 纯度
  Immunogen affinity purified
• 克隆
  多克隆
• 同种型
  IgG
• 研究领域
  • Epigenetics and Nuclear Signaling
  • DNA / RNA
  • DNA / Nucleotides

  • Cell Biology
  • Other Antibodies
  • Other Antibodies

相关产品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

应用

靶标

• 功能
  Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.
• 通路
  Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.
• 疾病相关
  Defects in HPRT1 are the cause of Lesch-Nyhan syndrome (LNS) [MIM:300322]. LNS is characterized by complete lack of enzymatic activity that results in hyperuricemia, choreoathetosis, mental retardation, and compulsive self-mutilation.
  Defects in HPRT1 are the cause of gout HPRT-related (GOUT-HPRT) [MIM:300323]; also known as HPRT-related gout or Kelley-Seegmiller syndrome. Gout is characterized by partial enzyme activity and hyperuricemia.
• 序列相似性
  Belongs to the purine/pyrimidine phosphoribosyltransferase family.
• 细胞定位
  Cytoplasm.

• Target information above from: UniProt accession P00492 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 281229 Cow
  • Entrez Gene: 3251 Human
  • Entrez Gene: 15452 Mouse
  • Entrez Gene: 24465 Rat
  • Entrez Gene: 406259 Zebrafish
  • Omim: 308000 Human
  • SwissProt: Q3SZ18 Cow
  • SwissProt: P00492 Human

  • SwissProt: P00493 Mouse
  • SwissProt: Q45FY6 Pig
  • SwissProt: P27605 Rat
  • Unigene: 412707 Human
  • Unigene: 299381 Mouse
  • Unigene: 47 Rat

  see all
• 别名
  • HGPRT antibody
  • HGPRTase antibody
  • HPRT 1 antibody

  • HPRT_HUMAN antibody
  • HPRT1 antibody
  • Hypoxanthine guanine phosphoribosyltransferase antibody
  • Hypoxanthine phosphoribosyltransferase 1 (Lesch Nyhan syndrome) antibody
  • Hypoxanthine phosphoribosyltransferase 1 antibody
  • Hypoxanthine-guanine phosphoribosyltransferase antibody

  see all

实验方案

• Western blot protocols