概述
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产品名称Anti-HPRT抗体
参阅全部 HPRT 一抗 -
描述兔多克隆抗体to HPRT
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宿主Rabbit
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经测试应用适用于: WBmore details
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种属反应性与反应: Human
预测可用于: Mouse, Rat, Rabbit, Cow, Dog, Pig, Zebrafish
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免疫原
Recombinant fragment, corresponding to amino acids 1-173 of Human HPRT (NP_000185).
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阳性对照
- IMR32 whole cell lysate; A549 and HCT116 cell lysates.
性能
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形式Liquid
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存放说明Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
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存储溶液Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0 -
Concentration information loading... -
纯度Immunogen affinity purified
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克隆多克隆
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同种型IgG
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研究领域
相关产品
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Compatible Secondaries
应用
Our Abpromise guarantee covers the use of ab97698 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | 1/1000. Predicted molecular weight: 25 kDa. |
靶标
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功能Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.
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通路Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1.
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疾病相关Defects in HPRT1 are the cause of Lesch-Nyhan syndrome (LNS) [MIM:300322]. LNS is characterized by complete lack of enzymatic activity that results in hyperuricemia, choreoathetosis, mental retardation, and compulsive self-mutilation.
Defects in HPRT1 are the cause of gout HPRT-related (GOUT-HPRT) [MIM:300323]; also known as HPRT-related gout or Kelley-Seegmiller syndrome. Gout is characterized by partial enzyme activity and hyperuricemia. -
序列相似性Belongs to the purine/pyrimidine phosphoribosyltransferase family.
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细胞定位Cytoplasm.
- Information by UniProt
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数据库链接
- Entrez Gene: 281229 Cow
- Entrez Gene: 3251 Human
- Entrez Gene: 15452 Mouse
- Entrez Gene: 24465 Rat
- Entrez Gene: 406259 Zebrafish
- Omim: 308000 Human
- SwissProt: Q3SZ18 Cow
- SwissProt: Q6WIT9 Dog
see all -
别名
- HGPRT antibody
- HGPRTase antibody
- HPRT 1 antibody
see all
图片
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Western blot - Anti-HPRT antibody (ab97698)Anti-HPRT antibody (ab97698) at 1/1000 dilution + IMR32 whole cell lysate at 30 µg
Predicted band size: 25 kDa
12% SDS-PAGE.
文献
ab97698 has not yet been referenced specifically in any publications.
客户评价及客户问答
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"