概述

  • 产品名称
  • 描述
    小鼠多克隆抗体to HP1BP3
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length human HP1BP3 protein, (NP_057371, 553 a.a)

  • 阳性对照
    • HP1BP3 transfected 293T lysate.

性能

应用

Our Abpromise guarantee covers the use of ab68719 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 75 kDa (predicted molecular weight: 61 kDa).

靶标

  • 功能
    Component of heterochromatin that maintains heterochromatin integrity during G1/S progression and regulates the duration of G1 phase to critically influence cell proliferative capacity (PubMed:24830416). Mediates chromatin condensation during hypoxia, leading to increased tumor cell viability, radio-resistance, chemo-resistance and self-renewal(PubMed:25100860).
  • 序列相似性
    Contains 3 H15 (linker histone H1/H5 globular) domains.
  • 结构域
    A central region that included the first H15 (linker histone H1/H5 globular) domain binds at the entry/exit site of the nucleosomal DNA.
  • 细胞定位
    Nucleus. Chromosome. localized in nuclei but not in nucleoli in interphase. Colocalized with chromosomes in mitosis, with a gradually increased during G1 progression and a maximum level during late G1 phase (G1/S).
  • Information by UniProt
  • 数据库链接
  • 别名
    • Heterochromatin protein 1, binding protein 3 antibody
    • Heterochromatin protein 1-binding protein 3 antibody
    • HP1 BP74 antibody
    • HP1B3_HUMAN antibody
    • HP1BP 3 antibody
    • HP1BP3 antibody
    • MGC28927 antibody
    • MGC43701 antibody
    • MGC72624 antibody
    • OTTHUMP00000002717 antibody
    • OTTHUMP00000002719 antibody
    • OTTHUMP00000002720 antibody
    • Protein HP1 BP74 antibody
    • Protein HP1-BP74 antibody
    • RP5 930J4.3 antibody
    see all

图片

  • All lanes : Anti-HP1BP3 antibody (ab68719) at 1/500 dilution

    Lane 1 : HP1BP3 transfected 293T lysate
    Lane 2 : Non-transfected 293T lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution

    Predicted band size : 61 kDa
    Observed band size : 75 kDa (why is the actual band size different from the predicted?)

实验方案

文献

ab68719 has not yet been referenced specifically in any publications.

客户评价及客户问答

There are currently no Customer reviews or Questions for ab68719.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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