概述

  • 产品名称Anti-HP1 gamma抗体
    参阅全部 HP1 gamma 一抗
  • 描述
    兔多克隆抗体to HP1 gamma
  • 经测试应用适用于: WB, ICC/IF, ChIPmore details
  • 种属反应性
    与反应: Hamster, Human
    预测可用于: Mouse, Chicken, Xenopus laevis, Drosophila melanogaster, Zebrafish, Xenopus tropicalis
  • 免疫原

    Synthetic peptide corresponding to Human HP1 gamma aa 174-183 (C terminal).
    Sequence:

    WHSCPEDEAQ-C


    Database link: Q13185

  • 阳性对照
    • MCF7 cell extract

性能

应用

Our Abpromise guarantee covers the use of ab122974 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/2000 - 1/10000. Predicted molecular weight: 20 kDa.
ICC/IF Use at an assay dependent concentration.
ChIP Use at an assay dependent concentration.

靶标

  • 功能Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
  • 序列相似性Contains 2 chromo domains.
  • 翻译后修饰Phosphorylated by PIM1. Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.
  • 细胞定位Nucleus. Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis.
  • Information by UniProt
  • 数据库链接
  • 别名
    • CBX 3 antibody
    • CBX3 antibody
    • CBX3_HUMAN antibody
    • Chromobox homolog 3 (HP1 gamma homolog, Drosophila) antibody
    • Chromobox homolog 3 antibody
    • Chromobox protein homolog 3 antibody
    • GAMMA antibody
    • HECH antibody
    • Heterochromatin like protein 1 antibody
    • Heterochromatin protein 1 homolog gamma antibody
    • Heterochromatin protein HP1 gamma antibody
    • HP1 gamma antibody
    • HP1 gamma homolog antibody
    • HP1Hs gamma antibody
    • Modifier 2 protein antibody
    see all

Anti-HP1 gamma antibody 图像

  • Anti-HP1 gamma antibody (ab122974) at 1/2000 dilution + Baby Hamster Kidney cells

    Predicted band size : 20 kDa

Anti-HP1 gamma antibody (ab122974)参考文献

ab122974 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"