概述

描述

  • 性质Synthetic
  • 来源CHO cells

技术指标

Our Abpromise guarantee covers the use of ab4718 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking - Blocking peptide for Anti-HP1 alpha antibody - Heterochromatin marker (ab9057)

  • 形式Liquid
  • 补充说明

    - First try to dissolve a small amount of peptide in either water or buffer. The more charged residues on a peptide, the more soluble it is in aqueous solutions.
    - If the peptide doesn’t dissolve try an organic solvent e.g. DMSO, then dilute using water or buffer.
    - Consider that any solvent used must be compatible with your assay. If a peptide does not dissolve and you need to recover it, lyophilise to remove the solvent.
    - Gentle warming and sonication can effectively aid peptide solubilisation. If the solution is cloudy or has gelled the peptide may be in suspension rather than solubilised.
    - Peptides containing cysteine are easily oxidised, so should be prepared in solution just prior to use.

  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Information available upon request.

常规信息

  • 别名
    • Antigen p25
    • CBX5
    • CBX5_HUMAN
    • CG8409
    • Chromobox 5
    • Chromobox homolog 5
    • Chromobox homolog 5 (HP1 alpha homolog, Drosophila)
    • Chromobox protein homolog 5
    • Epididymis luminal protein 25
    • HEL25
    • Heterochromatin protein 1
    • Heterochromatin protein 1 alpha
    • Heterochromatin protein 1 homolog alpha
    • HP1
    • HP1 alpha
    • HP1 alpha homolog
    • HP1A
    • HP1Hs alpha
    • Su(var)205
    see all
  • 功能Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
  • 序列相似性Contains 2 chromo domains.
  • 翻译后修饰Phosphorylation of HP1 and LBR may be responsible for some of the alterations in chromatin organization and nuclear structure which occur at various times during the cell cycle (By similarity). Phosphorylated during interphase and possibly hyper-phosphorylated during mitosis.
    Ubiquitinated.
  • 细胞定位Nucleus. Chromosome. Chromosome > centromere. Component of centromeric and pericentromeric heterochromatin. Associates with chromosomes during mitosis. Associates specifically with chromatin during metaphase and anaphase.
  • Information by UniProt

HP1 alpha peptide (ab4718)参考文献

ab4718 has not yet been referenced specifically in any publications.

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