概述

  • 产品名称
  • 描述
    山羊多克隆抗体to HOXD10
  • 经测试应用
    适用于: IHC-P, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Horse, Cow, Xenopus laevis, Chimpanzee
  • 免疫原

    Synthetic peptide:

    PNRSCRIEQPVTQQ

    , corresponding to internal sequence amino acids 84-97 of Human HOXD10 (NP_002139.2)

  • 阳性对照
    • Human Kidney lysate.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    Preservative: 0.02% Sodium Azide
    Constituents: 0.5% BSA, Tris buffered saline, pH 7.3
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 纯化说明
    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab85698 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use a concentration of 3 - 5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB Use a concentration of 0.2 - 0.6 µg/ml. Predicted molecular weight: 38 kDa.

靶标

  • 功能
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
  • 组织特异性
    Strongly expressed in the adult male and female urogenital tracts.
  • 疾病相关
    Defects in HOXD10 are a cause of congenital vertical talus (CVT) [MIM:192950]; also known as rocker-bottom foot deformity or congenital convex pes valgus. CVT is a dislocation of the talonavicular joint, with rigid dorsal dislocation of the navicular over the neck of the talus. This condition is usually associated with multiple other congenital deformities and only rarely is an isolated deformity.
  • 序列相似性
    Belongs to the Abd-B homeobox family.
    Contains 1 homeobox DNA-binding domain.
  • 发展阶段
    Expressed in the developing limb buds.
  • 细胞定位
    Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AI385591 antibody
    • AI874987 antibody
    • Homeo box 4D antibody
    • Homeo box D10 antibody
    • Homeobox D10 antibody
    • Homeobox protein Hox-4D antibody
    • Homeobox protein Hox-4E antibody
    • Homeobox protein Hox-D10 antibody
    • Hox 4.4 antibody
    • Hox 4.5 antibody
    • Hox 4D antibody
    • Hox 4E antibody
    • Hox 5.3 antibody
    • HOX4D antibody
    • HOX4E antibody
    • HOXD10 antibody
    • HXD10 antibody
    • HXD10_HUMAN antibody
    • OTTMUSP00000017845 antibody
    • RP23-313J15.9 antibody
    see all

图片

  • ab85698 (3.8µg/ml) staining of paraffin embedded Human Kidney following steamed antigen retrieval with citrate buffer pH 6 and AP-staining shows nuclear staining in some epithelial cells of PCT.

  • Anti-HOXD10 antibody (ab85698) at 0.2 µg/ml + Human Kidney lysate at 35 µg

    Predicted band size : 38 kDa
    Observed band size : 38 kDa
    Additional bands at : 26 kDa,90 kDa. We are unsure as to the identity of these extra bands.Additional bands of unknown identity were also consistently observed at 90+26 kDa. These bands were successfully blocked by incubation with the immunising peptide.

文献

ab85698 has not yet been referenced specifically in any publications.

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