Anti-hnRNP K (phospho S284)抗体(ab74066)

概述

• 产品名称Anti-hnRNP K (phospho S284)抗体
  参阅全部 hnRNP K 一抗
• 描述
  兔多克隆抗体to hnRNP K (phospho S284)
• 特异性ab74066 detects endogenous levels of hnRNP K only when phosphorylated at serine 284.
• 经测试应用适用于: WB, ELISAmore details
• 种属反应性
  与反应: Mouse, Human
  
• 免疫原

  Synthetic phosphopeptide derived from human hnRNP K around the phosphorylation site of serine 284 (D-M-S^P-P-R).

• 阳性对照
  • Extracts from 3T3 cells treated with EGF (200ng/ml, 30mins).

性能

• 形式Liquid
• 存放说明Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
• 存储溶液Preservative: 0.02% Sodium Azide
  Constituents: 50% Glycerol, PBS (without Mg²⁺ and Ca²⁺), 150mM Sodium chloride, pH 7.4
• Concentration information loading...
• 纯度Immunogen affinity purified
• 纯化说明ab74066 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific phosphopeptide. The antibody against non-phosphopeptide was removed by chromatography using non-phosphopeptide corresponding to the phosphorylation site.
• 克隆多克隆
• 同种型IgG
• 研究领域
  • Epigenetics and Nuclear Signaling
  • DNA / RNA
  • RNA Processing
  • Other

相关产品

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

应用

靶标

• 功能One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA.
• 序列相似性Contains 3 KH domains.
• 翻译后修饰Arg-296 and Arg-299 are dimethylated, probably to asymmetric dimethylarginine.
• 细胞定位Cytoplasm. Nucleus > nucleoplasm. In case of ASFV infection, there is a shift in the localization which becomes predominantly nuclear.

• Target information above from: UniProt accession P61978 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• 数据库链接
  • Entrez Gene: 3190 Human
  • Entrez Gene: 15387 Mouse
  • Omim: 600712 Human
  • SwissProt: P61978 Human
  • SwissProt: P61979 Mouse
  • Unigene: 522257 Human
  • Unigene: 142872 Mouse
• 别名
  • CSBP antibody
  • dC stretch binding protein antibody
  • FLJ41122 antibody

  • Heterogeneous nuclear ribonucleoprotein K antibody
  • hnRNP K antibody
  • HNRNPK antibody
  • HNRPK antibody
  • HNRPK_HUMAN antibody
  • Transformation up regulated nuclear protein antibody
  • Transformation up-regulated nuclear protein antibody
  • Transformation upregulated nuclear protein antibody
  • TUNP antibody

  see all