概述

  • 产品名称Anti-HNF1 beta抗体
    参阅全部 HNF1 beta 一抗
  • 描述
    小鼠单克隆抗体to HNF1 beta
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rat
  • 免疫原

    Recombinant fragment: ALEELLPSPN FGVKLETLPL SPGSGAEPDT KPVFHTLTNG HAKGRLSGDE GSEDGDDYDT PPILKELQAL NTEEAAEQRA EVDRMLSEDP, corresponding to amino acids 29-118 of human TCF2 with a tag.

  • 阳性对照
    • Recombinant human TCF2 protein fragment (immunogen); human lung cancer and human skin lysayes.

性能

应用

Our Abpromise guarantee covers the use of ab76914 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent dilution.
WB Use a concentration of 1 - 5 µg/ml. Predicted molecular weight: 61 kDa.

靶标

  • 功能Transcription factor, probably binds to the inverted palindrome 5'-GTTAATNATTAAC-3'.
  • 疾病相关Defects in HNF1B are the cause of renal cysts and diabetes syndrome (RCAD) [MIM:137920]; also called maturity-onset diabetes of the young type 5 (MODY5) or familial hypoplastic glomerulocystic kidney disease (GCKD). RCAD is an autosomal dominant disorder comprising non-diabetic renal disease resulting from abnormal renal development, and diabetes, which in some cases occurs earlier than age 25 years and is thus consistent with a diagnosis of maturity-onset diabetes of the young (MODY5). The renal disease is highly variable and includes renal cysts, glomerular tufts, aberrant nephrogenesis, primitive tubules, irregular collecting systems, oligomeganephronia, enlarged renal pelves, abnormal calyces, small kidney, single kidney, horseshoe kidney, and hyperuricemic nephropathy.
    Defects in HNF1B may be rare genetic risk factor contributing to the development of non-insulin-dependent diabetes mellitus (NIDDM) [MIM:125853]. NIDDM is characterized by an autosomal dominant mode of inheritance, onset during adulthood and insulin resistance.
    Defects in HNF1B may be a cause of susceptibility to prostate cancer hereditary type 11 (HPC11) [MIM:611955]. It is a condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
  • 序列相似性Belongs to the HNF1 homeobox family.
    Contains 1 homeobox DNA-binding domain.
  • 细胞定位Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • FJHN antibody
    • Hepatocyte nuclear factor 1 beta antibody
    • Hepatocyte nuclear factor 1-beta antibody
    • HNF 1B antibody
    • HNF 2 antibody
    • HNF-1-beta antibody
    • HNF-1B antibody
    • HNF1 beta antibody
    • HNF1 homeobox B antibody
    • HNF1B antibody
    • HNF1B_HUMAN antibody
    • HNF1beta antibody
    • HNF2 antibody
    • Homeoprotein LF B3 antibody
    • Homeoprotein LFB3 antibody
    • HPC11 antibody
    • LF B3 antibody
    • LFB3 antibody
    • MODY 5 antibody
    • MODY5 antibody
    • TCF 2 antibody
    • TCF 2 protein antibody
    • TCF-2 antibody
    • TCF2 antibody
    • TCF2 protein antibody
    • Transcription factor 2 antibody
    • Transcription factor 2 hepatic antibody
    • Variant hepatic nuclear factor 1 antibody
    • Variant hepatic nuclear factor antibody
    • VHNF 1 antibody
    • vHNF1 antibody
    see all

Anti-HNF1 beta antibody 图像

  • Anti-HNF1 beta antibody (ab76914) at 5 µg/ml + immunogen at 0.2 µg

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/5000 dilution

    Predicted band size : 61 kDa
    Observed band size : 36 kDa (why is the actual band size different from the predicted?)
  • Anti-HNF1 beta antibody (ab76914) at 5 µg/ml + human lung cancer tissue lysate at 25 µg

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 61 kDa
    Observed band size : 49 kDa (why is the actual band size different from the predicted?)
  • Anti-HNF1 beta antibody (ab76914) at 5 µg/ml + human skin tissue lysate at 25 µg

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

    Predicted band size : 61 kDa
    Observed band size : 50 kDa (why is the actual band size different from the predicted?)

Anti-HNF1 beta antibody (ab76914)参考文献

ab76914 has not yet been referenced specifically in any publications.

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