Anti-HLA Class II DRB3抗体(ab98107)

概述

  • 产品名称Anti-HLA Class II DRB3抗体
  • 描述
    兔多克隆抗体to HLA Class II DRB3
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Monkey
  • 免疫原

    Amino acids 4 - 260 of Human HLA Class II DRB3 (NP_072049).

  • 阳性对照
    • A549 and HCT116 cell lysates

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 0.01% Thimerosal (merthiolate)
    Constituents: 10% Glycerol, 0.1M Tris, 0.1M Glycine, pH 7.0
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

相关产品

应用

Our Abpromise guarantee covers the use of ab98107 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Predicted molecular weight: 30 kDa.

靶标

  • 相关性HLA Class II DRB3 belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DRA) and a beta (DRB) chain, both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. The presence of DRB3 is linked with allelic variants of DRB1, otherwise it is omitted. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.
  • 细胞定位Cell membrane; Endoplasmic reticulum membrane; Golgi apparatus, trans-Golgi network membrane; Endosome membrane; Lysosome membrane; Late endosome membrane. Note: The MHC class II complex transits through a number of intracellular compartments in the endocytic pathway until it reaches the cell membrane for antigen presentation.
  • 数据库链接
  • 别名
    • HLA class II histocompatibility antigen DR beta 3 chain antibody
    • HLA DR3B antibody
    • HLADR3B antibody
    • Major histocompatibility complex, class II DR beta 3 antibody

Anti-HLA Class II DRB3 antibody 图像

  • Anti-HLA Class II DRB3 antibody (ab98107) at 1/1000 dilution + A549 whole cell lysate at 30 µg

    Predicted band size : 30 kDa

Anti-HLA Class II DRB3 antibody (ab98107)参考文献

ab98107 has not yet been referenced specifically in any publications.

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