概述

  • 产品名称Anti-HIV1 Nef抗体
    参阅全部 HIV1 Nef 一抗
  • 描述
    豚鼠多克隆抗体to HIV1 Nef
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    Reacts with HIV-1.
  • 免疫原

    Recombinant Nef protein over-expressed in E. coli with a plasmid carrying the Nef coding region of HIV1 virus, subtype B.

  • 阳性对照
    • Extract of MT4 cells uninfected or infected with HIV1 (LAI strain).

性能

应用

Our Abpromise guarantee covers the use of ab63919 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Predicted molecular weight: 24 kDa.
ELISA Use at an assay dependent dilution.

靶标

  • 相关性Nef is a early protein that appears to play a role in optimizing the host cell environment for viral replication without causing cell death by apoptosis. Nef enhances virus infectivity and pathogenicity. It down modulates surface MHC I molecules and internalized molecules are sequested to the trans-Golgi network. The number of cell surface CD4 antigen are decreased by interacting with the Src family kinase LCK thereby inducing LCK CD4 dissociation and by increasing clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation.
  • 别名
    • C terminal core protein antibody
    • F protein antibody
    • Nef antibody
    • Negative factor antibody
    • p27 antibody
    see all

Anti-HIV1 Nef antibody 图像

  • All lanes : Anti-HIV1 Nef antibody (ab63919) at 1/1000 dilution

    Lane 1 : Extract of MT4 cells
    Lane 2 : Extract of MT4 cells infected with HIV1 (LAI strain)


    Predicted band size : 24 kDa
    Observed band size : 27 kDa (why is the actual band size different from the predicted?)

Anti-HIV1 Nef antibody (ab63919)参考文献

ab63919 has not yet been referenced specifically in any publications.

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