Anti-Histone H3 (tri methyl K36)抗体- ChIP Grade (ab9050)

发表研究结果有使用 ab9050?请让我们知道,以便我们可以引用本数据表中的参考文章。

ab9050 被引用在 456 文献中.

  • Janke R  et al. Oncometabolite D-2-Hydroxyglutarate enhances gene silencing through inhibition of specific H3K36 histone demethylases. Elife 6:N/A (2017). WB ; Saccharomyces cerevisiae . PubMed: 28346139
  • Wu H  et al. Chromatin dynamics regulate mesenchymal stem cell lineage specification and differentiation to osteogenesis. Biochim Biophys Acta 1860:438-449 (2017). ChIP . PubMed: 28077316
  • Young CP  et al. Distinct histone methylation and transcription profiles are established during the development of cellular quiescence in yeast. BMC Genomics 18:107 (2017). WB, ChIP ; Saccharomyces cerevisiae . PubMed: 28122508
  • Guitart AV  et al. Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions. J Exp Med 214:719-735 (2017). WB ; Mouse . PubMed: 28202494
  • Soboleva TA  et al. A new link between transcriptional initiation and pre-mRNA splicing: The RNA binding histone variant H2A.B. PLoS Genet 13:e1006633 (2017). ChIP ; Mouse . PubMed: 28234895
  • Flury V  et al. The Histone Acetyltransferase Mst2 Protects Active Chromatin from Epigenetic Silencing by Acetylating the Ubiquitin Ligase Brl1. Mol Cell 67:294-307.e9 (2017). ChIP ; Schizosaccharomyces pombe . PubMed: 28648780
  • Sanders D  et al. Histone Lysine-to-Methionine Mutations Reduce Histone Methylation and Cause Developmental Pleiotropy. Plant Physiol 173:2243-2252 (2017). WB . PubMed: 28202597
  • Du Y  et al. Nucleosome eviction along with H3K9ac deposition enhances Sox2 binding during human neuroectodermal commitment. Cell Death Differ 24:1121-1131 (2017). CHIPseq ; Human . PubMed: 28475175
  • Sayou C  et al. RNA Binding by Histone Methyltransferases Set1 and Set2. Mol Cell Biol 37:N/A (2017). WB ; Saccharomyces cerevisiae . PubMed: 28483910
  • McDaniel SL  et al. H3K36 Methylation Regulates Nutrient Stress Response in Saccharomyces cerevisiae by Enforcing Transcriptional Fidelity. Cell Rep 19:2371-2382 (2017). Saccharomyces cerevisiae . PubMed: 28614721
  • Yadav RK  et al. Histone H3G34R mutation causes replication stress, homologous recombination defects and genomic instability in S. pombe. Elife 6:N/A (2017). PubMed: 28718400
  • Jensen GS  et al. The RNA Polymerase-Associated Factor 1 Complex Is Required for Plant Touch Responses. J Exp Bot 68:499-511 (2017). WB . PubMed: 28204553
  • Natale F  et al. Identification of the elementary structural units of the DNA damage response. Nat Commun 8:15760 (2017). PubMed: 28604675
  • Battaglia S  et al. RNA-dependent chromatin association of transcription elongation factors and Pol II CTD kinases. Elife 6:N/A (2017). PubMed: 28537551
  • Wollmann H  et al. The histone H3 variant H3.3 regulates gene body DNA methylation in Arabidopsis thaliana. Genome Biol 18:94 (2017). PubMed: 28521766
  • Pajoro A  et al. Histone H3 lysine 36 methylation affects temperature-induced alternative splicing and flowering in plants. Genome Biol 18:102 (2017). PubMed: 28566089
  • Elnfati AH  et al. Nucleosomal chromatin in the mature sperm of Drosophila melanogaster. Genom Data 7:175-7 (2016). PubMed: 26981400
  • Guryanova OA  et al. DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling. Nat Med 22:1488-1495 (2016). PubMed: 27841873
  • Adhikary S  et al. Selective Recognition of H3.1K36 Dimethylation/H4K16 Acetylation Facilitates the Regulation of All-trans-retinoic Acid (ATRA)-responsive Genes by Putative Chromatin Reader ZMYND8. J Biol Chem 291:2664-81 (2016). PubMed: 26655721
  • Richarson AD  et al. Registered report: IDH mutation impairs histone demethylation and results in a block to cell differentiation. Elife 5:e10860 (2016). PubMed: 26971564
  • Kim TD  et al. ETS transcription factor ERG cooperates with histone demethylase KDM4A. Oncol Rep 35:3679-88 (2016). ChIP . PubMed: 27109047
  • Li D  et al. Profiling Analysis of Histone Modifications and Gene Expression in Lewis Lung Carcinoma Murine Cells Resistant to Anti-VEGF Treatment. PLoS One 11:e0158214 (2016). ChIP . PubMed: 27362259
  • McKnight RA  et al. Intrauterine growth restriction inhibits expression of eukaryotic elongation factor 2 kinase, a regulator of protein translation. Physiol Genomics 48:616-25 (2016). ChIP ; Rat . PubMed: 27317589
  • Su Z  et al. Reader domain specificity and lysine demethylase-4 family function. Nat Commun 7:13387 (2016). WB ; Mouse . PubMed: 27841353
  • Venkatesh S  et al. Selective suppression of antisense transcription by Set2-mediated H3K36 methylation. Nat Commun 7:13610 (2016). WB, ChIP ; Saccharomyces cerevisiae . PubMed: 27892455
  • Kim JH  et al. Modulation of mRNA and lncRNA expression dynamics by the Set2-Rpd3S pathway. Nat Commun 7:13534 (2016). ChIP ; Saccharomyces cerevisiae . PubMed: 27892458
  • Miyazato P  et al. Application of targeted enrichment to next-generation sequencing of retroviruses integrated into the host human genome. Sci Rep 6:28324 (2016). PubMed: 27321866
  • Li R  et al. Misregulation of Alternative Splicing in a Mouse Model of Rett Syndrome. PLoS Genet 12:e1006129 (2016). ChIP . PubMed: 27352031
  • Jones JW  et al. Recruitment of Saccharomyces cerevisiae Cmr1/Ydl156w to Coding Regions Promotes Transcription Genome Wide. PLoS One 11:e0148897 (2016). ChIP ; Saccharomyces cerevisiae . PubMed: 26848854
  • Romanello M  et al. Histone H3.3 promotes IgV gene diversification by enhancing formation of AID-accessible single-stranded DNA. EMBO J 35:1452-64 (2016). ChIP ; Chicken . PubMed: 27220848
  • Ahn JH  et al. A Conserved Nuclear Cyclophilin Is Required for Both RNA Polymerase II Elongation and Co-transcriptional Splicing in Caenorhabditis elegans. PLoS Genet 12:e1006227 (2016). WB ; Caenorhabditis elegans . PubMed: 27541139
  • Yang Y  et al. PAF Complex Plays Novel Subunit-Specific Roles in Alternative Cleavage and Polyadenylation. PLoS Genet 12:e1005794 (2016). WB, ChIP ; Mouse . PubMed: 26765774
  • Bieberstein NI  et al. TALE-directed local modulation of H3K9 methylation shapes exon recognition. Sci Rep 6:29961 (2016). ChIP . PubMed: 27439481
  • Savic D  et al. Distinct gene regulatory programs define the inhibitory effects of liver X receptors and PPARG on cancer cell proliferation. Genome Med 8:74 (2016). CHIPseq ; Human . PubMed: 27401066
  • Meyer MB  et al. Epigenetic Plasticity Drives Adipogenic and Osteogenic Differentiation of Marrow-derived Mesenchymal Stem Cells. J Biol Chem 291:17829-47 (2016). PubMed: 27402842
  • Lee S  et al. Global Regulation of Plant Immunity by Histone Lysine Methyl Transferases. Plant Cell 28:1640-61 (2016). WB ; Arabidopsis thaliana . PubMed: 27354553
  • Tamaoki K  et al. Morphological, biochemical, transcriptional and epigenetic responses to fasting and refeeding in intestine of Xenopus laevis. Cell Biosci 6:2 (2016). PubMed: 26798452
  • Feng J  et al. ZRF1 Chromatin Regulators Have Polycomb Silencing and Independent Roles in Development. Plant Physiol 172:1746-1759 (2016). WB ; Arabidopsis thaliana . PubMed: 27630184
  • Mathew RS  et al. A microRNA negative feedback loop downregulates vesicle transport and inhibits fear memory. Elife 5:N/A (2016). ChIP ; Rat . PubMed: 28001126
  • Das D  et al. Anti-viral role of toll like receptor 4 in hepatitis B virus infection: An in vitro study. World J Gastroenterol 22:10341-10352 (2016). WB ; Human . PubMed: 28058014
  • Tan PY  et al. E2F1 Orchestrates Transcriptomics and Oxidative Metabolism in Wharton's Jelly-Derived Mesenchymal Stem Cells from Growth-Restricted Infants. PLoS One 11:e0163035 (2016). ChIP ; Human . PubMed: 27631473
  • Natisvili T  et al. Transcriptional Activation of Pericentromeric Satellite Repeats and Disruption of Centromeric Clustering upon Proteasome Inhibition. PLoS One 11:e0165873 (2016). ChIP ; Mouse . PubMed: 27806100
  • Ni T  et al. Global intron retention mediated gene regulation during CD4+ T cell activation. Nucleic Acids Res 44:6817-29 (2016). ChIP ; Human . PubMed: 27369383
  • Hunter GO  et al. Phosphatase Rtr1 Regulates Global Levels of Serine 5 RNA Polymerase II C-Terminal Domain Phosphorylation and Cotranscriptional Histone Methylation. Mol Cell Biol 36:2236-45 (2016). PubMed: 27247267
  • Hacker KE  et al. Structure/Function Analysis of Recurrent Mutations in SETD2 Protein Reveals a Critical and Conserved Role for a SET Domain Residue in Maintaining Protein Stability and Histone H3 Lys-36 Trimethylation. J Biol Chem 291:21283-21295 (2016). PubMed: 27528607
  • Wu Z  et al. Quantitative regulation of FLC via coordinated transcriptional initiation and elongation. Proc Natl Acad Sci U S A 113:218-23 (2016). ChIP . PubMed: 26699513
  • Stubbs SH & Conrad NK Depletion of REF/Aly alters gene expression and reduces RNA polymerase II occupancy. Nucleic Acids Res 43:504-19 (2015). PubMed: 25477387
  • Saloura V  et al. WHSC1 promotes oncogenesis through regulation of NIMA-related kinase-7 in squamous cell carcinoma of the head and neck. Mol Cancer Res 13:293-304 (2015). WB ; Human . PubMed: 25280969
  • Lee J  et al. A methyltransferase required for proper timing of the vernalization response in Arabidopsis. Proc Natl Acad Sci U S A 112:2269-74 (2015). WB ; Arabidopsis thaliana . PubMed: 25605879
  • Li P  et al. Phenotypic evolution through variation in splicing of the noncoding RNA COOLAIR. Genes Dev 29:696-701 (2015). ChIP . PubMed: 25805848
  • Kelly S  et al. Splicing of many human genes involves sites embedded within introns. Nucleic Acids Res 43:4721-32 (2015). ChIP ; Human . PubMed: 25897131
  • Cucinotta CE  et al. The Nucleosome Acidic Patch Regulates the H2B K123 Monoubiquitylation Cascade and Transcription Elongation in Saccharomyces cerevisiae. PLoS Genet 11:e1005420 (2015). WB . PubMed: 26241481
  • Mbogning J  et al. Functional interaction of Rpb1 and Spt5 C-terminal domains in co-transcriptional histone modification. Nucleic Acids Res 43:9766-75 (2015). WB ; Schizosaccharomyces pombe . PubMed: 26275777
  • Hou Y  et al. JMJ704 positively regulates rice defense response against Xanthomonas oryzae pv. oryzae infection via reducing H3K4me2/3 associated with negative disease resistance regulators. BMC Plant Biol 15:286 (2015). WB ; Rice . PubMed: 26646110
  • Rathert P  et al. Transcriptional plasticity promotes primary and acquired resistance to BET inhibition. Nature 525:543-7 (2015). PubMed: 26367798
  • Carey BW  et al. Intracellular a-ketoglutarate maintains the pluripotency of embryonic stem cells. Nature 518:413-6 (2015). WB ; Mouse . PubMed: 25487152
  • Duncan EM  et al. Set1 and MLL1/2 Target Distinct Sets of Functionally Different Genomic Loci In Vivo. Cell Rep 13:2741-55 (2015). ChIP ; Schmidtea mediterranea . PubMed: 26711341
  • Hodges AJ  et al. Histone Sprocket Arginine Residues Are Important for Gene Expression, DNA Repair, and Cell Viability in Saccharomyces cerevisiae. Genetics 200:795-806 (2015). WB . PubMed: 25971662
  • Krivega I  et al. Inhibition of G9a methyltransferase stimulates fetal hemoglobin production by facilitating LCR/?-globin looping. Blood 126:665-72 (2015). ChIP . PubMed: 25979948
  • Preissl S  et al. Deciphering the Epigenetic Code of Cardiac Myocyte Transcription. Circ Res 117:413-23 (2015). ChIP . PubMed: 26105955
  • Alekseyenko AA  et al. The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains. Genes Dev 29:1507-23 (2015). ChIP ; Human . PubMed: 26220994
  • Ohhata T  et al. Histone H3 Lysine 36 Trimethylation Is Established over the Xist Promoter by Antisense Tsix Transcription and Contributes to Repressing Xist Expression. Mol Cell Biol 35:3909-20 (2015). WB, ChIP . PubMed: 26370508
  • Li Y  et al. Arginine Methyltransferase 1 in the Nucleus Accumbens Regulates Behavioral Effects of Cocaine. J Neurosci 35:12890-902 (2015). WB ; Mouse . PubMed: 26377474
  • Masuda Y  et al. TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin. Nat Commun 6:7299 (2015). Human . PubMed: 26095369
  • Ji X  et al. Chromatin proteomic profiling reveals novel proteins associated with histone-marked genomic regions. Proc Natl Acad Sci U S A 112:3841-6 (2015). WB, ChIP, CHIPseq ; Mouse . PubMed: 25755260
  • Sharma G  et al. The interaction of mycobacterial protein Rv2966c with host chromatin is mediated through non-CpG methylation and histone H3/H4 binding. Nucleic Acids Res 43:3922-37 (2015). WB ; Human . PubMed: 25824946
  • Pu M  et al. Trimethylation of Lys36 on H3 restricts gene expression change during aging and impacts life span. Genes Dev 29:718-31 (2015). ChIP ; Caenorhabditis elegans . PubMed: 25838541
  • Kim HJ  et al. Identification of a new selective chemical inhibitor of mutant isocitrate dehydrogenase-1. J Cancer Prev 20:78-83 (2015). WB ; Human . PubMed: 25853107
  • Jin J  et al. MORF-RELATED GENE702, a Reader Protein of Trimethylated Histone H3 Lysine 4 and Histone H3 Lysine 36, Is Involved in Brassinosteroid-Regulated Growth and Flowering Time Control in Rice. Plant Physiol 168:1275-85 (2015). ChIP, Dot blot, ICC/IF ; Rice . PubMed: 25855537
  • Guo Z  et al. Global epigenomic analysis indicates that epialleles contribute to Allele-specific expression via Allele-specific histone modifications in hybrid rice. BMC Genomics 16:232 (2015). CHIPseq ; Rice . PubMed: 25886904
  • Engel KL  et al. Spt6 Is Essential for rRNA Synthesis by RNA Polymerase I. Mol Cell Biol 35:2321-31 (2015). ChIP ; Saccharomyces cerevisiae . PubMed: 25918242
  • Kowalik KM  et al. The Paf1 complex represses small-RNA-mediated epigenetic gene silencing. Nature 520:248-252 (2015). ChIP ; Schizosaccharomyces pombe . PubMed: 25807481
  • Chen CW  et al. DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia. Nat Med 21:335-43 (2015). PubMed: 25822366
  • Zhu J  et al. Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth. Nature 525:206-11 (2015). WB ; Human . PubMed: 26331536
  • Hontelez S  et al. Embryonic transcription is controlled by maternally defined chromatin state. Nat Commun 6:10148 (2015). ChIP ; Xenopus tropicalis . PubMed: 26679111
  • Wong SH  et al. The H3K4-Methyl Epigenome Regulates Leukemia Stem Cell Oncogenic Potential. Cancer Cell 28:198-209 (2015). ChIP ; Mouse, Human . PubMed: 26190263
  • Pérez-Lluch S  et al. Absence of canonical marks of active chromatin in developmentally regulated genes. Nat Genet 47:1158-1167 (2015). ChIP ; Drosophila melanogaster . PubMed: 26280901
  • Yao X  et al. The Mediator subunit MED23 couples H2B mono-ubiquitination to transcriptional control and cell fate determination. EMBO J 34:2885-902 (2015). WB . PubMed: 26330467
  • Biagioli M  et al. Htt CAG repeat expansion confers pleiotropic gains of mutant huntingtin function in chromatin regulation. Hum Mol Genet 24:2442-57 (2015). ChIP ; Mouse . PubMed: 25574027
  • Koo JW  et al. Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area. Nat Neurosci 18:415-22 (2015). ChIP ; Rat . PubMed: 25643298
  • Gjoneska E  et al. Conserved epigenomic signals in mice and humans reveal immune basis of Alzheimer's disease. Nature 518:365-9 (2015). ChIP ; Mouse . PubMed: 25693568
  • Kanu N  et al. SETD2 loss-of-function promotes renal cancer branched evolution through replication stress and impaired DNA repair. Oncogene 34:5699-708 (2015). WB, IHC-P, ChIP ; Human . PubMed: 25728682
  • Morselli M  et al. In vivo targeting of de novo DNA methylation by histone modifications in yeast and mouse. Elife 4:e06205 (2015). ChIP . PubMed: 25848745
  • Rothbart SB  et al. An Interactive Database for the Assessment of Histone Antibody Specificity. Mol Cell 59:502-11 (2015). PubMed: 26212453
  • Ferrari P & Strubin M Uncoupling histone turnover from transcription-associated histone H3 modifications. Nucleic Acids Res 43:3972-85 (2015). ChIP ; Saccharomyces cerevisiae . PubMed: 25845593
  • Wang Y  et al. Balancing acts of SRI and an auto-inhibitory domain specify Set2 function at transcribed chromatin. Nucleic Acids Res 43:4881-92 (2015). WB, ChIP ; Saccharomyces cerevisiae . PubMed: 25925577
  • Maekawa S  et al. Analysis of RNA decay factor mediated RNA stability contributions on RNA abundance. BMC Genomics 16:154 (2015). ChIP ; Human . PubMed: 25879614
  • Lu S  et al. The transcription factor c-Fos coordinates with histone lysine-specific demethylase 2A to activate the expression of cyclooxygenase-2. Oncotarget 6:34704-17 (2015). WB . PubMed: 26430963
  • Reeder JE  et al. HIV Tat controls RNA Polymerase II and the epigenetic landscape to transcriptionally reprogram target immune cells. Elife 4:N/A (2015). ChIP . PubMed: 26488441
  • Bercht Pfleghaar K  et al. Gene-rich chromosomal regions are preferentially localized in the lamin B deficient nuclear blebs of atypical progeria cells. Nucleus 6:66-76 (2015). PubMed: 25738644
  • Kang S  et al. Identification of nuclear hormone receptor pathways causing insulin resistance by transcriptional and epigenomic analysis. Nat Cell Biol 17:44-56 (2015). PubMed: 25503565
  • Wallace HA  et al. Condensin II Regulates Interphase Chromatin Organization Through the Mrg-Binding Motif of Cap-H2. G3 (Bethesda) 5:803-17 (2015). PubMed: 25758823
  • Liu W  et al. Decreased Expression of SETD2 Predicts Unfavorable Prognosis in Patients With Nonmetastatic Clear-Cell Renal Cell Carcinoma. Medicine (Baltimore) 94:e2004 (2015). IHC . PubMed: 26559293
  • Park JL  et al. Decrease of 5hmC in gastric cancers is associated with TET1 silencing due to with DNA methylation and bivalent histone marks at TET1 CpG island 3'-shore. Oncotarget 6:37647-62 (2015). ChIP . PubMed: 26462176
  • Xiang W  et al. miR-106b-5p targets tumor suppressor gene SETD2 to inactive its function in clear cell renal cell carcinoma. Oncotarget 6:4066-79 (2015). WB . PubMed: 25714014
  • Liu Y & Zhang D HP1a/KDM4A is involved in the autoregulatory loop of the oncogene gene c-Jun. Epigenetics 10:453-9 (2015). PubMed: 25945750
  • Li D  et al. Epigenetic regulation of traf2- and Nck-interacting kinase (TNIK) in polycystic ovary syndrome. Am J Transl Res 7:1152-60 (2015). PubMed: 26279758
  • Nag A  et al. Chromatin Signature Identifies Monoallelic Gene Expression Across Mammalian Cell Types. G3 (Bethesda) 5:1713-20 (2015). ChIP . PubMed: 26092837
  • Takahashi JS  et al. ChIP-seq and RNA-seq methods to study circadian control of transcription in mammals. Methods Enzymol 551:285-321 (2015). PubMed: 25662462
  • Mikula M  et al. Obesity increases histone H3 lysine 9 and 18 acetylation at Tnfa and Ccl2 genes in mouse liver. Int J Mol Med 34:1647-54 (2014). PubMed: 25319795
  • Hon GC  et al. 5mC oxidation by Tet2 modulates enhancer activity and timing of transcriptome reprogramming during differentiation. Mol Cell 56:286-97 (2014). PubMed: 25263596
  • Kurachi M  et al. The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8+ T cells. Nat Immunol 15:373-83 (2014). ChIP . PubMed: 24584090
  • Zhu X  et al. Identification of functional cooperative mutations of SETD2 in human acute leukemia. Nat Genet 46:287-93 (2014). PubMed: 24509477
  • Song G  et al. The phenotypic predisposition of the parent in F1 hybrid is correlated with transcriptome preference of the positive general combining ability parent. BMC Genomics 15:297 (2014). ChIP . PubMed: 24755044
  • Muratani M  et al. Nanoscale chromatin profiling of gastric adenocarcinoma reveals cancer-associated cryptic promoters and somatically acquired regulatory elements. Nat Commun 5:4361 (2014). PubMed: 25008978
  • Wen H  et al. ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression. Nature 508:263-8 (2014). PubMed: 24590075
  • Li XY  et al. Establishment of regions of genomic activity during the Drosophila maternal to zygotic transition. Elife 3:N/A (2014). ChIP . PubMed: 25313869
  • Cascante A  et al. Gene-specific methylation control of H3K9 and H3K36 on neurotrophic BDNF versus astroglial GFAP genes by KDM4A/C regulates neural stem cell differentiation. J Mol Biol 426:3467-77 (2014). PubMed: 24747049
  • St John HC  et al. The osteoblast to osteocyte transition: epigenetic changes and response to the vitamin D3 hormone. Mol Endocrinol 28:1150-65 (2014). PubMed: 24877565
  • Aymard F  et al. Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks. Nat Struct Mol Biol 21:366-74 (2014). ChIP . PubMed: 24658350
  • Jha DK & Strahl BD An RNA polymerase II-coupled function for histone H3K36 methylation in checkpoint activation and DSB repair. Nat Commun 5:3965 (2014). ChIP . PubMed: 24910128
  • Kryczek I  et al. IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L. Immunity 40:772-784 (2014). PubMed: 24816405
  • Cecere G  et al. Global effects of the CSR-1 RNA interference pathway on the transcriptional landscape. Nat Struct Mol Biol 21:358-65 (2014). ChIP . PubMed: 24681887
  • Light N  et al. Interrogation of allelic chromatin states in human cells by high-density ChIP-genotyping. Epigenetics 9:1238-51 (2014). PubMed: 25055051
  • Liu X  et al. The rice enhancer of zeste [E(z)] genes SDG711 and SDG718 are respectively involved in long day and short day signaling to mediate the accurate photoperiod control of flowering time. Front Plant Sci 5:591 (2014). WB . PubMed: 25400654
  • Magraner-Pardo L  et al. Dynamic remodeling of histone modifications in response to osmotic stress in Saccharomyces cerevisiae. BMC Genomics 15:247 (2014). ChIP . PubMed: 24678875
  • Park D  et al. Chd1 co-localizes with early transcription elongation factors independently of H3K36 methylation and releases stalled RNA polymerase II at introns. Epigenetics Chromatin 7:32 (2014). WB . PubMed: 25395991
  • Walsh CA  et al. Global gene repression by the steroid receptor coactivator SRC-1 promotes oncogenesis. Cancer Res 74:2533-44 (2014). PubMed: 24648347
  • Aguilar R  et al. A functional N-terminal domain in C/EBPß-LAP* is required for interacting with SWI/SNF and to repress Ric-8B gene transcription in osteoblasts. J Cell Physiol 229:1521-8 (2014). PubMed: 24585571
  • Gan ES  et al. Jumonji demethylases moderate precocious flowering at elevated temperature via regulation of FLC in Arabidopsis. Nat Commun 5:5098 (2014). PubMed: 25267112
  • Hérissant L  et al. H2B ubiquitylation modulates spliceosome assembly and function in budding yeast. Biol Cell 106:126-38 (2014). ChIP . PubMed: 24476359
  • Hackermüller J  et al. Cell cycle, oncogenic and tumor suppressor pathways regulate numerous long and macro non-protein-coding RNAs. Genome Biol 15:R48 (2014). ChIP ; Human . PubMed: 24594072
  • Descostes N  et al. Tyrosine phosphorylation of RNA polymerase II CTD is associated with antisense promoter transcription and active enhancers in mammalian cells. Elife 3:e02105 (2014). ChIP ; Human . PubMed: 24842994
  • Li T & Kelly WG A role for WDR5 in TRA-1/Gli mediated transcriptional control of the sperm/oocyte switch in C. elegans. Nucleic Acids Res 42:5567-81 (2014). ChIP ; Human . PubMed: 24682813
  • Knoechel B  et al. An epigenetic mechanism of resistance to targeted therapy in T cell acute lymphoblastic leukemia. Nat Genet 46:364-70 (2014). ChIP ; Human . PubMed: 24584072
  • Kumar RM  et al. Deconstructing transcriptional heterogeneity in pluripotent stem cells. Nature 516:56-61 (2014). PubMed: 25471879
  • Creppe C  et al. A Cbx8-containing polycomb complex facilitates the transition to gene activation during ES cell differentiation. PLoS Genet 10:e1004851 (2014). PubMed: 25500566
  • Schiavone D  et al. Determinants of G quadruplex-induced epigenetic instability in REV1-deficient cells. EMBO J 33:2507-20 (2014). PubMed: 25190518
  • Gilbert TM  et al. A PWWP domain-containing protein targets the NuA3 acetyltransferase complex via histone H3 lysine 36 trimethylation to coordinate transcriptional elongation at coding regions. Mol Cell Proteomics 13:2883-95 (2014). PubMed: 25104842
  • Kungulovski G  et al. Application of histone modification-specific interaction domains as an alternative to antibodies. Genome Res 24:1842-53 (2014). PubMed: 25301795
  • Csorba T  et al. Antisense COOLAIR mediates the coordinated switching of chromatin states at FLC during vernalization. Proc Natl Acad Sci U S A 111:16160-5 (2014). ChIP . PubMed: 25349421
  • Sharma A  et al. Calcium-mediated histone modifications regulate alternative splicing in cardiomyocytes. Proc Natl Acad Sci U S A 111:E4920-8 (2014). PubMed: 25368158
  • Suzuki A  et al. Aberrant transcriptional regulations in cancers: genome, transcriptome and epigenome analysis of lung adenocarcinoma cell lines. Nucleic Acids Res 42:13557-72 (2014). CHIPseq ; Human . PubMed: 25378332
  • Ginsburg DS  et al. NuA4 links methylation of histone H3 lysines 4 and 36 to acetylation of histones H4 and H3. J Biol Chem 289:32656-70 (2014). PubMed: 25301943
  • Veerappan V  et al. HSI2/VAL1 PHD-like domain promotes H3K27 trimethylation to repress the expression of seed maturation genes and complex transgenes in Arabidopsis seedlings. BMC Plant Biol 14:293 (2014). ChIP ; Plants . PubMed: 25367506
  • Chakravarty D  et al. The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer. Nat Commun 5:5383 (2014). ChIP ; Human . PubMed: 25415230
  • Zheng Y  et al. A developmental genetic analysis of the lysine demethylase KDM2 mutations in Drosophila melanogaster. Mech Dev 133:36-53 (2014). WB ; Drosophila melanogaster . PubMed: 25016215
  • Bu Z  et al. Regulation of arabidopsis flowering by the histone mark readers MRG1/2 via interaction with CONSTANS to modulate FT expression. PLoS Genet 10:e1004617 (2014). ChIP, Dot blot ; Arabidopsis thaliana . PubMed: 25211338
  • Crevillén P  et al. Epigenetic reprogramming that prevents transgenerational inheritance of the vernalized state. Nature N/A:N/A (2014). PubMed: 25219852
  • Popovic R  et al. Histone methyltransferase MMSET/NSD2 alters EZH2 binding and reprograms the myeloma epigenome through global and focal changes in H3K36 and H3K27 methylation. PLoS Genet 10:e1004566 (2014). ChIP ; Human . PubMed: 25188243
  • Lee YF  et al. Histone H3 lysine 36 methyltransferase Whsc1 promotes the association of Runx2 and p300 in the activation of bone-related genes. PLoS One 9:e106661 (2014). ChIP ; Mouse . PubMed: 25188294
  • Bonnet J  et al. The SAGA coactivator complex acts on the whole transcribed genome and is required for RNA polymerase II transcription. Genes Dev 28:1999-2012 (2014). PubMed: 25228644
  • Fuchs G  et al. Cotranscriptional histone H2B monoubiquitylation is tightly coupled with RNA polymerase II elongation rate. Genome Res 24:1572-83 (2014). PubMed: 25049226
  • Xu Y  et al. Arabidopsis MRG domain proteins bridge two histone modifications to elevate expression of flowering genes. Nucleic Acids Res 42:10960-74 (2014). PubMed: 25183522
  • Marcinkiewicz KM & Gudas LJ Altered histone mark deposition and DNA methylation at homeobox genes in human oral squamous cell carcinoma. J Cell Physiol 229:1405-16 (2014). PubMed: 24519855
  • Yun WJ  et al. The hematopoietic regulator TAL1 is required for chromatin looping between the ß-globin LCR and human ?-globin genes to activate transcription. Nucleic Acids Res 42:4283-93 (2014). ChIP ; Human . PubMed: 24470145
  • Fowler T  et al. Regulation of MYC expression and differential JQ1 sensitivity in cancer cells. PLoS One 9:e87003 (2014). ChIP . PubMed: 24466310
  • Simon JM  et al. Variation in chromatin accessibility in human kidney cancer links H3K36 methyltransferase loss with widespread RNA processing defects. Genome Res 24:241-50 (2014). Human . PubMed: 24158655
  • Zhang Y  et al. Canonical nucleosome organization at promoters forms during genome activation. Genome Res 24:260-6 (2014). Zebrafish . PubMed: 24285721
  • Looney TJ  et al. Systematic mapping of occluded genes by cell fusion reveals prevalence and stability of cis-mediated silencing in somatic cells. Genome Res 24:267-80 (2014). ChIP . PubMed: 24310002
  • Akbay EA  et al. D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice. Genes Dev 28:479-90 (2014). WB . PubMed: 24589777
  • Pedersen MT  et al. The demethylase JMJD2C localizes to H3K4me3-positive transcription start sites and is dispensable for embryonic development. Mol Cell Biol 34:1031-45 (2014). PubMed: 24396064
  • Convertini P  et al. Sudemycin E influences alternative splicing and changes chromatin modifications. Nucleic Acids Res 42:4947-61 (2014). ChIP ; Human . PubMed: 24623796
  • Yukawa M  et al. Genome-wide analysis of the chromatin composition of histone H2A and H3 variants in mouse embryonic stem cells. PLoS One 9:e92689 (2014). ChIP ; Mouse . PubMed: 24658136
  • Suzuki MG  et al. Effects of RNAi-mediated knockdown of histone methyltransferases on the sex-specific mRNA expression of Imp in the silkworm Bombyx mori. Int J Mol Sci 15:6772-96 (2014). ChIP ; Silk worm . PubMed: 24758924
  • Kupershmit I  et al. KDM4C (GASC1) lysine demethylase is associated with mitotic chromatin and regulates chromosome segregation during mitosis. Nucleic Acids Res 42:6168-82 (2014). WB ; Human . PubMed: 24728997
  • Zhang H  et al. Uncoupling transcription from covalent histone modification. PLoS Genet 10:e1004202 (2014). ChIP . PubMed: 24722509
  • Long L  et al. The U4/U6 recycling factor SART3 has histone chaperone activity and associates with USP15 to regulate H2B deubiquitination. J Biol Chem 289:8916-30 (2014). PubMed: 24526689
  • Fonseca GJ  et al. Adenovirus E1A recruits the human Paf1 complex to enhance transcriptional elongation. J Virol 88:5630-7 (2014). Human . PubMed: 24600005
  • Carvalho S  et al. SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint. Elife 3:e02482 (2014). WB, ChIP ; Human . PubMed: 24843002
  • Pai CC  et al. A histone H3K36 chromatin switch coordinates DNA double-strand break repair pathway choice. Nat Commun 5:4091 (2014). WB . PubMed: 24909977
  • Cooper S  et al. Targeting Polycomb to Pericentric Heterochromatin in Embryonic Stem Cells Reveals a Role for H2AK119u1 in PRC2 Recruitment. Cell Rep 7:1456-70 (2014). CHIPseq ; Human . PubMed: 24857660
  • Rossetto D  et al. Eaf5/7/3 form a functionally independent NuA4 submodule linked to RNA polymerase II-coupled nucleosome recycling. EMBO J 33:1397-415 (2014). PubMed: 24843044
  • Mercier A  et al. Site-Specific Association with Host and Viral Chromatin by Kaposi's Sarcoma-Associated Herpesvirus LANA and Its Reversal during Lytic Reactivation. J Virol 88:6762-6777 (2014). PubMed: 24696474
  • Pfister SX  et al. SETD2-Dependent Histone H3K36 Trimethylation Is Required for Homologous Recombination Repair and Genome Stability. Cell Rep 7:2006-18 (2014). ChIP, ICC/IF, WB, IP ; Human . PubMed: 24931610
  • Lhoumaud P  et al. Insulators recruit histone methyltransferase dMes4 to regulate chromatin of flanking genes. EMBO J 33:1599-613 (2014). PubMed: 24916307
  • Meyer MB  et al. The RUNX2 Cistrome in Osteoblasts: CHARACTERIZATION, DOWN-REGULATION FOLLOWING DIFFERENTIATION, AND RELATIONSHIP TO GENE EXPRESSION. J Biol Chem 289:16016-16031 (2014). ChIP ; Mouse . PubMed: 24764292
  • Yang X  et al. Histone modifications are associated with ?9-tetrahydrocannabinol-mediated alterations in antigen-specific T cell responses. J Biol Chem 289:18707-18 (2014). ChIP ; Mouse . PubMed: 24841204
  • Meyer MB  et al. Genomic determinants of gene regulation by 1,25-dihydroxyvitamin D3 during osteoblast-lineage cell differentiation. J Biol Chem 289:19539-54 (2014). Mouse . PubMed: 24891508
  • Tarrio ML  et al. Proliferation conditions promote intrinsic changes in NK cells for an IL-10 response. J Immunol 193:354-63 (2014). PubMed: 24907347
  • Lee SM  et al. HBx induces hypomethylation of distal intragenic CpG islands required for active expression of developmental regulators. Proc Natl Acad Sci U S A 111:9555-60 (2014). Mouse . PubMed: 24941955
  • da Glória VG  et al. T cell activation regulates CD6 alternative splicing by transcription dynamics and SRSF1. J Immunol 193:391-9 (2014). Human . PubMed: 24890719
  • Matsumoto K  et al. Construction of mate pair full-length cDNAs libraries and characterization of transcriptional start sites and termination sites. Nucleic Acids Res N/A:N/A (2014). CHIPseq ; Human . PubMed: 25034687
  • Wang X  et al. Histone lysine methyltransferase SDG8 is involved in brassinosteroid-regulated gene expression in Arabidopsis thaliana. Mol Plant 7:1303-15 (2014). PubMed: 24838002
  • Hou X  et al. Nuclear factor Y-mediated H3K27me3 demethylation of the SOC1 locus orchestrates flowering responses of Arabidopsis. Nat Commun 5:4601 (2014). Arabidopsis thaliana . PubMed: 25105952
  • Kuang Z  et al. High-temporal-resolution view of transcription and chromatin states across distinct metabolic states in budding yeast. Nat Struct Mol Biol N/A:N/A (2014). Saccharomyces cerevisiae . PubMed: 25173176
  • Xue Z  et al. Transcriptional interference by antisense RNA is required for circadian clock function. Nature N/A:N/A (2014). PubMed: 25132551
  • Fowler T  et al. Regulation of primary response genes in B cells. J Biol Chem 288:14906-16 (2013). ChIP ; Mouse . PubMed: 23536186
  • Jack AP  et al. H3K56me3 is a novel, conserved heterochromatic mark that largely but not completely overlaps with H3K9me3 in both regulation and localization. PLoS One 8:e51765 (2013). WB . PubMed: 23451023
  • Hahn MA  et al. Dynamics of 5-hydroxymethylcytosine and chromatin marks in Mammalian neurogenesis. Cell Rep 3:291-300 (2013). ChIP . PubMed: 23403289
  • Ho LL  et al. DOT1L-mediated H3K79 methylation in chromatin is dispensable for Wnt pathway-specific and other intestinal epithelial functions. Mol Cell Biol 33:1735-45 (2013). WB ; Mouse . PubMed: 23428873
  • Suzuki J  et al. A novel small compound SH-2251 suppresses Th2 cell-dependent airway inflammation through selective modulation of chromatin status at the Il5 gene locus. PLoS One 8:e61785 (2013). ChIP . PubMed: 23613936
  • Dreidax D  et al. Low p14ARF expression in neuroblastoma cells is associated with repressed histone mark status, and enforced expression induces growth arrest and apoptosis. Hum Mol Genet 22:1735-45 (2013). Human . PubMed: 23343716
  • van Nuland R  et al. Nucleosomal DNA binding drives the recognition of H3K36-methylated nucleosomes by the PSIP1-PWWP domain. Epigenetics Chromatin 6:12 (2013). PubMed: 23656834
  • Fontebasso AM  et al. Mutations in SETD2 and genes affecting histone H3K36 methylation target hemispheric high-grade gliomas. Acta Neuropathol 125:659-69 (2013). WB . PubMed: 23417712
  • Michaud J  et al. HCFC1 is a common component of active human CpG-island promoters and coincides with ZNF143, THAP11, YY1, and GABP transcription factor occupancy. Genome Res 23:907-16 (2013). PubMed: 23539139
  • Young LC  et al. Kdm4b histone demethylase is a DNA damage response protein and confers a survival advantage following ?-irradiation. J Biol Chem 288:21376-88 (2013). PubMed: 23744078
  • Eun B  et al. The Igf2/H19 muscle enhancer is an active transcriptional complex. Nucleic Acids Res 41:8126-34 (2013). PubMed: 23842673
  • Hatzi K  et al. A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters. Cell Rep 4:578-88 (2013). ChIP . PubMed: 23911289
  • Lodrini M  et al. MYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma. Nucleic Acids Res 41:6018-33 (2013). ChIP . PubMed: 23625969
  • Wang D  et al. MicroRNA-205 controls neonatal expansion of skin stem cells by modulating the PI(3)K pathway. Nat Cell Biol 15:1153-63 (2013). PubMed: 23974039
  • Sarai N  et al. WHSC1 links transcription elongation to HIRA-mediated histone H3.3 deposition. EMBO J 32:2392-406 (2013). PubMed: 23921552
  • Aristizabal MJ  et al. High-throughput genetic and gene expression analysis of the RNAPII-CTD reveals unexpected connections to SRB10/CDK8. PLoS Genet 9:e1003758 (2013). ChIP/Chip . PubMed: 24009531
  • Lu C  et al. Induction of sarcomas by mutant IDH2. Genes Dev 27:1986-98 (2013). PubMed: 24065766
  • Cie Lik M  et al. Epigenetic coordination of signaling pathways during the epithelial-mesenchymal transition. Epigenetics Chromatin 6:28 (2013). CHIPseq . PubMed: 24004852
  • Jaffe JD  et al. Global chromatin profiling reveals NSD2 mutations in pediatric acute lymphoblastic leukemia. Nat Genet 45:1386-91 (2013). PubMed: 24076604
  • Ding L  et al. FLOWERING LOCUS C EXPRESSOR family proteins regulate FLOWERING LOCUS C expression in both winter-annual and rapid-cycling Arabidopsis. Plant Physiol 163:243-52 (2013). PubMed: 23899645
  • Millán-Zambrano G  et al. The prefoldin complex regulates chromatin dynamics during transcription elongation. PLoS Genet 9:e1003776 (2013). ChIP ; Saccharomyces cerevisiae . PubMed: 24068951
  • Ravnskjaer K  et al. Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects. J Clin Invest 123:4318-28 (2013). WB, IP . PubMed: 24051374
  • Yuan G  et al. Histone H2A Ubiquitination Inhibits the Enzymatic Activity of H3 Lysine 36 Methyltransferases. J Biol Chem 288:30832-42 (2013). IP ; Mouse . PubMed: 24019522
  • Wier AD  et al. Structural basis for Spt5-mediated recruitment of the Paf1 complex to chromatin. Proc Natl Acad Sci U S A 110:17290-5 (2013). WB ; Saccharomyces cerevisiae . PubMed: 24101474
  • Henriquez B  et al. Ezh1 and Ezh2 differentially regulate PSD-95 gene transcription in developing hippocampal neurons. Mol Cell Neurosci 57:130-43 (2013). ChIP ; Rat . PubMed: 23932971
  • Parker SC  et al. Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants. Proc Natl Acad Sci U S A 110:17921-6 (2013). IP ; Human . PubMed: 24127591
  • Solovei I  et al. LBR and lamin A/C sequentially tether peripheral heterochromatin and inversely regulate differentiation. Cell 152:584-98 (2013). PubMed: 23374351
  • Cui X  et al. Control of transposon activity by a histone H3K4 demethylase in rice. Proc Natl Acad Sci U S A 110:1953-8 (2013). PubMed: 23319643
  • Kuwahara Y  et al. SNF5 reexpression in malignant rhabdoid tumors regulates transcription of target genes by recruitment of SWI/SNF complexes and RNAPII to the transcription start site of their promoters. Mol Cancer Res 11:251-60 (2013). PubMed: 23364536
  • Wang L  et al. Genome-wide maps of polyadenylation reveal dynamic mRNA 3'-end formation in mammalian cell lineages. RNA 19:413-25 (2013). PubMed: 23325109
  • Bevington S & Boyes J Transcription-coupled eviction of histones H2A/H2B governs V(D)J recombination. EMBO J 32:1381-92 (2013). PubMed: 23463099
  • Ko YA  et al. Cytosine methylation changes in enhancer regions of core pro-fibrotic genes characterize kidney fibrosis development. Genome Biol 14:R108 (2013). ChIP ; Human . PubMed: 24098934
  • Jäger N  et al. Hypermutation of the inactive x chromosome is a frequent event in cancer. Cell 155:567-81 (2013). ChIP ; Human . PubMed: 24139898
  • Zhou Q  et al. The epigenome of evolving Drosophila neo-sex chromosomes: dosage compensation and heterochromatin formation. PLoS Biol 11:e1001711 (2013). CHIPseq . PubMed: 24265597
  • Cotton AM  et al. Analysis of expressed SNPs identifies variable extents of expression from the human inactive X chromosome. Genome Biol 14:R122 (2013). ChIP . PubMed: 24176135
  • Lim HJ  et al. The G2/M regulator histone demethylase PHF8 is targeted for degradation by the anaphase-promoting complex containing CDC20. Mol Cell Biol 33:4166-80 (2013). PubMed: 23979597
  • DeGennaro CM  et al. Spt6 regulates intragenic and antisense transcription, nucleosome positioning, and histone modifications genome-wide in fission yeast. Mol Cell Biol 33:4779-92 (2013). WB . PubMed: 24100010
  • Wagner KW  et al. KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling. J Clin Invest 123:5231-46 (2013). PubMed: 24200691
  • Mbogning J  et al. The PAF complex and Prf1/Rtf1 delineate distinct Cdk9-dependent pathways regulating transcription elongation in fission yeast. PLoS Genet 9:e1004029 (2013). WB . PubMed: 24385927
  • Wang AH  et al. The histone chaperone Spt6 coordinates histone H3K27 demethylation and myogenesis. EMBO J 32:1075-86 (2013). WB, ChIP ; Mouse . PubMed: 23503590
  • Balasubramanian MN  et al. Dynamic changes in genomic histone association and modification during activation of the ASNS and ATF3 genes by amino acid limitation. Biochem J 449:219-29 (2013). PubMed: 22978410
  • Huang XA  et al. A major epigenetic programming mechanism guided by piRNAs. Dev Cell 24:502-16 (2013). PubMed: 23434410
  • Yu P  et al. Spatiotemporal clustering of the epigenome reveals rules of dynamic gene regulation. Genome Res 23:352-64 (2013). PubMed: 23033340
  • Kumar V  et al. Uniform, optimal signal processing of mapped deep-sequencing data. Nat Biotechnol 31:615-22 (2013). PubMed: 23770639
  • Nag A  et al. Chromatin signature of widespread monoallelic expression. Elife 2:e01256 (2013). ChIP . PubMed: 24381246
  • Burton A  et al. Inositol pyrophosphates regulate JMJD2C-dependent histone demethylation. Proc Natl Acad Sci U S A 110:18970-5 (2013). PubMed: 24191012
  • Valin A  et al. Transcription factor Sp3 represses expression of p21CIP¹ via inhibition of productive elongation by RNA polymerase II. Mol Cell Biol 33:1582-93 (2013). PubMed: 23401853
  • Wu F & Yao J Spatial compartmentalization at the nuclear periphery characterized by genome-wide mapping. BMC Genomics 14:591 (2013). PubMed: 23987233
  • Chen M  et al. Decoupling epigenetic and genetic effects through systematic analysis of gene position. Cell Rep 3:128-37 (2013). ChIP . PubMed: 23291096
  • Sugathan A & Waxman DJ Genome-wide analysis of chromatin states reveals distinct mechanisms of sex-dependent gene regulation in male and female mouse liver. Mol Cell Biol 33:3594-610 (2013). PubMed: 23836885
  • Carvalho S  et al. Histone methyltransferase SETD2 coordinates FACT recruitment with nucleosome dynamics during transcription. Nucleic Acids Res 41:2881-93 (2013). WB, IP, ChIP . PubMed: 23325844
  • Williams A  et al. Hypersensitive site 6 of the Th2 locus control region is essential for Th2 cytokine expression. Proc Natl Acad Sci U S A 110:6955-60 (2013). ChIP . PubMed: 23569250
  • Chen Q  et al. Structural basis of a histone H3 lysine 4 demethylase required for stem elongation in rice. PLoS Genet 9:e1003239 (2013). PubMed: 23357881
  • Connolly LR  et al. The Fusarium graminearum histone H3 K27 methyltransferase KMT6 regulates development and expression of secondary metabolite gene clusters. PLoS Genet 9:e1003916 (2013). WB . PubMed: 24204317
  • Zhang K  et al. CTR9/PAF1c regulates molecular lineage identity, histone H3K36 trimethylation and genomic imprinting during preimplantation development. Dev Biol 383:15-27 (2013). PubMed: 24036311
  • Bjerke L  et al. Histone H3.3. mutations drive pediatric glioblastoma through upregulation of MYCN. Cancer Discov 3:512-9 (2013). PubMed: 23539269
  • Alekseyenko AA  et al. Conservation and de novo acquisition of dosage compensation on newly evolved sex chromosomes in Drosophila. Genes Dev 27:853-8 (2013). PubMed: 23630075
  • Kim W  et al. Targeted disruption of the EZH2-EED complex inhibits EZH2-dependent cancer. Nat Chem Biol 9:643-50 (2013). WB . PubMed: 23974116
  • Crona F  et al. Gene regulation by the lysine demethylase KDM4A in Drosophila. Dev Biol 373:453-63 (2013). PubMed: 23195220
  • Li T  et al. Jumonji C domain protein JMJ705-mediated removal of histone H3 lysine 27 trimethylation is involved in defense-related gene activation in rice. Plant Cell 25:4725-36 (2013). PubMed: 24280387
  • Sun C  et al. The histone methyltransferase SDG724 mediates H3K36me2/3 deposition at MADS50 and RFT1 and promotes flowering in rice. Plant Cell 24:3235-47 (2012). PubMed: 22892321
  • Zhang X  et al. Integrative functional genomics identifies an enhancer looping to the SOX9 gene disrupted by the 17q24.3 prostate cancer risk locus. Genome Res 22:1437-46 (2012). PubMed: 22665440
  • Zhang Y  et al. Reduction of hox gene expression by histone h1 depletion. PLoS One 7:e38829 (2012). ChIP . PubMed: 22701719
  • Tippmann SC  et al. Chromatin measurements reveal contributions of synthesis and decay to steady-state mRNA levels. Mol Syst Biol 8:593 (2012). ChIP . PubMed: 22806141
  • Tomasiewicz HC  et al. Proenkephalin mediates the enduring effects of adolescent cannabis exposure associated with adult opiate vulnerability. Biol Psychiatry 72:803-10 (2012). PubMed: 22683090
  • Sasaki M  et al. IDH1(R132H) mutation increases murine haematopoietic progenitors and alters epigenetics. Nature 488:656-9 (2012). WB . PubMed: 22763442
  • Chen Y  et al. Systematic evaluation of factors influencing ChIP-seq fidelity. Nat Methods 9:609-14 (2012). ChIP . PubMed: 22522655
  • Jin B  et al. Linking DNA methyltransferases to epigenetic marks and nucleosome structure genome-wide in human tumor cells. Cell Rep 2:1411-24 (2012). PubMed: 23177624
  • Boškovic A  et al. Analysis of active chromatin modifications in early mammalian embryos reveals uncoupling of H2A.Z acetylation and H3K36 trimethylation from embryonic genome activation. Epigenetics 7:747-57 (2012). PubMed: 22647320
  • Tyan SW  et al. Breast cancer cells induce stromal fibroblasts to secrete ADAMTS1 for cancer invasion through an epigenetic change. PLoS One 7:e35128 (2012). ChIP . PubMed: 22514714
  • Paige SL  et al. A temporal chromatin signature in human embryonic stem cells identifies regulators of cardiac development. Cell 151:221-32 (2012). ChIP . PubMed: 22981225
  • Bellemer C  et al. Microprocessor dynamics and interactions at endogenous imprinted C19MC microRNA genes. J Cell Sci 125:2709-20 (2012). PubMed: 22393237
  • Canella D  et al. A multiplicity of factors contributes to selective RNA polymerase III occupancy of a subset of RNA polymerase III genes in mouse liver. Genome Res 22:666-80 (2012). PubMed: 22287103
  • Liang G  et al. Kdm2b promotes induced pluripotent stem cell generation by facilitating gene activation early in reprogramming. Nat Cell Biol 14:457-66 (2012). PubMed: 22522173
  • Santostefano KE  et al. Fibroblast growth factor receptor 2 homodimerization rapidly reduces transcription of the pluripotency gene Nanog without dissociation of activating transcription factors. J Biol Chem 287:30507-17 (2012). ChIP . PubMed: 22787153
  • Raab JR  et al. Human tRNA genes function as chromatin insulators. EMBO J 31:330-50 (2012). PubMed: 22085927
  • Goula AV  et al. Transcription elongation and tissue-specific somatic CAG instability. PLoS Genet 8:e1003051 (2012). ChIP . PubMed: 23209427
  • Sasaki M  et al. D-2-hydroxyglutarate produced by mutant IDH1 perturbs collagen maturation and basement membrane function. Genes Dev 26:2038-49 (2012). WB . PubMed: 22925884
  • Youn MY  et al. JMJD5, a Jumonji C (JmjC) Domain-containing Protein, Negatively Regulates Osteoclastogenesis by Facilitating NFATc1 Protein Degradation. J Biol Chem 287:12994-3004 (2012). PubMed: 22375008
  • Abdel-Wahab O  et al. ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression. Cancer Cell 22:180-93 (2012). ChIP . PubMed: 22897849
  • Darvekar S  et al. Identification of two independent nucleosome-binding domains in the transcriptional co-activator SPBP. Biochem J 442:65-75 (2012). PubMed: 22081970
  • Gaertner B  et al. Poised RNA polymerase II changes over developmental time and prepares genes for future expression. Cell Rep 2:1670-83 (2012). PubMed: 23260668
  • Zhao JC  et al. Cooperation between Polycomb and androgen receptor during oncogenic transformation. Genome Res 22:322-31 (2012). ChIP . PubMed: 22179855
  • Le Martelot G  et al. Genome-wide RNA polymerase II profiles and RNA accumulation reveal kinetics of transcription and associated epigenetic changes during diurnal cycles. PLoS Biol 10:e1001442 (2012). ChIP . PubMed: 23209382
  • Chen J  et al. Single-molecule tools elucidate H2A.Z nucleosome composition. J Cell Sci 125:2954-64 (2012). PubMed: 22393239
  • Hon GC  et al. Global DNA hypomethylation coupled to repressive chromatin domain formation and gene silencing in breast cancer. Genome Res 22:246-58 (2012). CHIPseq . PubMed: 22156296
  • Faure AJ  et al. Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules. Genome Res 22:2163-75 (2012). PubMed: 22780989
  • Onoguchi M  et al. A noncoding RNA regulates the neurogenin1 gene locus during mouse neocortical development. Proc Natl Acad Sci U S A 109:16939-44 (2012). ChIP . PubMed: 23027973
  • Lin CH  et al. HP1a targets the Drosophila KDM4A demethylase to a subset of heterochromatic genes to regulate H3K36me3 levels. PLoS One 7:e39758 (2012). ChIP . PubMed: 22761891
  • Pan D  et al. The histone demethylase jhdm1a regulates hepatic gluconeogenesis. PLoS Genet 8:e1002761 (2012). ChIP . PubMed: 22719268
  • Stender JD  et al. Control of proinflammatory gene programs by regulated trimethylation and demethylation of histone H4K20. Mol Cell 48:28-38 (2012). WB ; Mouse . PubMed: 22921934
  • Zhang W  et al. High-resolution mapping of open chromatin in the rice genome. Genome Res 22:151-62 (2012). ChIP ; Rice . PubMed: 22110044
  • Lu C  et al. IDH mutation impairs histone demethylation and results in a block to cell differentiation. Nature 483:474-8 (2012). PubMed: 22343901
  • Mulji A  et al. Configuration of a high-content imaging platform for hit identification and pharmacological assessment of JMJD3 demethylase enzyme inhibitors. J Biomol Screen 17:108-20 (2012). PubMed: 22223398
  • Raynal NJ  et al. DNA methylation does not stably lock gene expression but instead serves as a molecular mark for gene silencing memory. Cancer Res 72:1170-81 (2012). ChIP . PubMed: 22219169
  • Kirigin FF  et al. Dynamic microRNA gene transcription and processing during T cell development. J Immunol 188:3257-67 (2012). CHIPseq ; Mouse . PubMed: 22379031
  • Fang TC  et al. Histone H3 lysine 9 di-methylation as an epigenetic signature of the interferon response. J Exp Med 209:661-9 (2012). PubMed: 22412156
  • Hsu DW  et al. Dynamic acetylation of lysine-4-trimethylated histone H3 and H3 variant biology in a simple multicellular eukaryote. Nucleic Acids Res : (2012). PubMed: 22600736
  • Pradeepa MM  et al. Psip1/Ledgf p52 binds methylated histone H3K36 and splicing factors and contributes to the regulation of alternative splicing. PLoS Genet 8:e1002717 (2012). WB . PubMed: 22615581
  • Birnbaum RY  et al. Coding exons function as tissue-specific enhancers of nearby genes. Genome Res 22:1059-68 (2012). ChIP . PubMed: 22442009
  • Pinheiro A  et al. Demethylation of the coding region triggers the activation of the human testis-specific PDHA2 gene in somatic tissues. PLoS One 7:e38076 (2012). ChIP . PubMed: 22675509
  • Bourbousse C  et al. Histone H2B monoubiquitination facilitates the rapid modulation of gene expression during Arabidopsis photomorphogenesis. PLoS Genet 8:e1002825 (2012). ChIP . PubMed: 22829781
  • Pinter SF  et al. Spreading of X chromosome inactivation via a hierarchy of defined Polycomb stations. Genome Res 22:1864-76 (2012). ChIP . PubMed: 22948768
  • Lin YC  et al. Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate. Nat Immunol 13:1196-204 (2012). CHIPseq ; Mouse . PubMed: 23064439
  • Qi W  et al. Selective inhibition of Ezh2 by a small molecule inhibitor blocks tumor cells proliferation. Proc Natl Acad Sci U S A 109:21360-5 (2012). PubMed: 23236167
  • Bilesimo P  et al. Specific histone lysine 4 methylation patterns define TR-binding capacity and differentiate direct T3 responses. Mol Endocrinol 25:225-37 (2011). ChIP ; Xenopus laevis . PubMed: 21239616
  • Ai N  et al. Signal-induced Brd4 release from chromatin is essential for its role transition from chromatin targeting to transcriptional regulation. Nucleic Acids Res 39:9592-604 (2011). PubMed: 21890894
  • Fuchs SM  et al. RNA polymerase ii CTD phosphorylation regulates stability of the SET2 methyltransferase and histone H3 DI- and trimethylation at lysine 36. J Biol Chem : (2011). PubMed: 22157004
  • Regnard C  et al. Global Analysis of the Relationship between JIL-1 Kinase and Transcription. PLoS Genet 7:e1001327 (2011). ChIP ; Drosophila melanogaster . PubMed: 21423663
  • Wu SF  et al. Genes for embryo development are packaged in blocks of multivalent chromatin in zebrafish sperm. Genome Res 21:578-89 (2011). WB ; Zebrafish . PubMed: 21383318
  • Crisucci EM & Arndt KM The Paf1 complex represses ARG1 transcription in Saccharomyces cerevisiae by promoting histone modifications. Eukaryot Cell 10:712-23 (2011). ChIP . PubMed: 21498644
  • Hahn MA  et al. Relationship between gene body DNA methylation and intragenic H3K9me3 and H3K36me3 chromatin marks. PLoS One 6:e18844 (2011). ChIP . PubMed: 21526191
  • Pérez-Lluch S  et al. Genome-wide chromatin occupancy analysis reveals a role for ASH2 in transcriptional pausing. Nucleic Acids Res 39:4628-39 (2011). ChIP . PubMed: 21310711
  • Zhang L  et al. Stable and dynamic nucleosome states during a meiotic developmental process. Genome Res 21:875-84 (2011). PubMed: 21515815
  • Cheung MS  et al. Systematic bias in high-throughput sequencing data and its correction by BEADS. Nucleic Acids Res 39:e103 (2011). PubMed: 21646344
  • De Gobbi M  et al. Generation of bivalent chromatin domains during cell fate decisions. Epigenetics Chromatin 4:9 (2011). ChIP ; Human . PubMed: 21645363
  • Kwon DW & Ahn SH Role of yeast JmjC-domain containing histone demethylases in actively transcribed regions. Biochem Biophys Res Commun 410:614-9 (2011). PubMed: 21684259
  • Trejbalová K  et al. Epigenetic regulation of transcription and splicing of syncytins, fusogenic glycoproteins of retroviral origin. Nucleic Acids Res 39:8728-39 (2011). ChIP ; Human . PubMed: 21771862
  • Widiez T  et al. High nitrogen insensitive 9 (HNI9)-mediated systemic repression of root NO3- uptake is associated with changes in histone methylation. Proc Natl Acad Sci U S A 108:13329-34 (2011). ChIP . PubMed: 21788519
  • Hainer SJ & Martens JA Identification of histone mutants that are defective for transcription-coupled nucleosome occupancy. Mol Cell Biol 31:3557-68 (2011). WB ; Saccharomyces cerevisiae . PubMed: 21730290
  • Zhang CC  et al. RPL1, a Gene Involved in Epigenetic Processes Regulates Phenotypic Plasticity in Rice. Mol Plant : (2011). PubMed: 22131052
  • Movassagh M  et al. Distinct epigenomic features in end-stage failing human hearts. Circulation 124:2411-22 (2011). ChIP ; Human . PubMed: 22025602
  • Rahman S  et al. The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3. Mol Cell Biol 31:2641-52 (2011). ChIP . PubMed: 21555454
  • Hung T  et al. Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters. Nat Genet 43:621-9 (2011). ChIP ; Human . PubMed: 21642992
  • Xie L  et al. KDM5B regulates embryonic stem cell self-renewal and represses cryptic intragenic transcription. EMBO J 30:1473-84 (2011). WB ; Mouse . PubMed: 21448134
  • Wilhelm BT  et al. Differential patterns of intronic and exonic DNA regions with respect to RNA polymerase II occupancy, nucleosome density and H3K36me3 marking in fission yeast. Genome Biol 12:R82 (2011). ChIP/Chip ; Schizosaccharomyces pombe . PubMed: 21859475
  • Shieh GS  et al. H2B ubiquitylation is part of chromatin architecture that marks exon-intron structure in budding yeast. BMC Genomics 12:627 (2011). ChIP ; Saccharomyces cerevisiae . PubMed: 22188810
  • Milcarek C  et al. The Eleven-Nineteen Lysine-rich Leukemia Gene (ELL2) Influences the Histone H3 Protein Modifications Accompanying the Shift to Secretory Immunoglobulin Heavy Chain mRNA Production. J Biol Chem 286:33795-803 (2011). ChIP ; Mouse . PubMed: 21832080
  • Yildirim E  et al. X-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription. Nat Struct Mol Biol 19:56-61 (2011). ChIP . PubMed: 22139016
  • Chantalat S  et al. Histone H3 trimethylation at lysine 36 is associated with constitutive and facultative heterochromatin. Genome Res 21:1426-37 (2011). PubMed: 21803857
  • Jang IC  et al. Rapid and reversible light-mediated chromatin modifications of Arabidopsis phytochrome A locus. Plant Cell 23:459-70 (2011). ChIP . PubMed: 21317377
  • Gardner KE  et al. Identification of lysine 37 of histone H2B as a novel site of methylation. PLoS One 6:e16244 (2011). WB . PubMed: 21249157
  • Dayal S  et al. High resolution analysis of the chromatin landscape of the IgE switch region in human B cells. PLoS One 6:e24571 (2011). ChIP ; Human . PubMed: 21949728
  • Nakayamada S  et al. Early Th1 cell differentiation is marked by a Tfh cell-like transition. Immunity 35:919-31 (2011). PubMed: 22195747
  • Wong P  et al. Gene induction and repression during terminal erythropoiesis are mediated by distinct epigenetic changes. Blood 118:e128-38 (2011). ChIP . PubMed: 21860024
  • Toyokawa G  et al. Histone lysine methyltransferase Wolf-Hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway. Neoplasia 13:887-98 (2011). PubMed: 22028615
  • Tan MK  et al. SCF(FBXO22) regulates histone H3 lysine 9 and 36 methylation levels by targeting histone demethylase KDM4A for ubiquitin-mediated proteasomal degradation. Mol Cell Biol 31:3687-99 (2011). PubMed: 21768309
  • Wu Y  et al. Euchromatic subdomains in rice centromeres are associated with genes and transcription. Plant Cell 23:4054-64 (2011). ChIP ; Rice . PubMed: 22080597
  • Ernst J  et al. Mapping and analysis of chromatin state dynamics in nine human cell types. Nature 473:43-9 (2011). PubMed: 21441907
  • Kumari D  et al. Repeat expansion affects both transcription initiation and elongation in friedreich ataxia cells. J Biol Chem 286:4209-15 (2011). ChIP . PubMed: 21127046
  • Zhang J  et al. Harnessing of the nucleosome-remodeling-deacetylase complex controls lymphocyte development and prevents leukemogenesis. Nat Immunol 13:86-94 (2011). PubMed: 22080921
  • McDonald OG  et al. Genome-scale epigenetic reprogramming during epithelial-to-mesenchymal transition. Nat Struct Mol Biol 18:867-74 (2011). PubMed: 21725293
  • Hoppmann V  et al. The CW domain, a new histone recognition module in chromatin proteins. EMBO J 30:1939-52 (2011). PubMed: 21522130
  • Wang D  et al. Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA. Nature 474:390-4 (2011). PubMed: 21572438
  • Pekowska A  et al. H3K4 tri-methylation provides an epigenetic signature of active enhancers. EMBO J 30:4198-210 (2011). PubMed: 21847099
  • Gordon JA  et al. Epigenetic regulation of early osteogenesis and mineralized tissue formation by a HOXA10-PBX1-associated complex. Cells Tissues Organs 194:146-50 (2011). PubMed: 21597276
  • Batta K  et al. Genome-wide function of H2B ubiquitylation in promoter and genic regions. Genes Dev 25:2254-65 (2011). ChIP . PubMed: 22056671
  • Wang T  et al. The histone demethylases Jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner. Cell Stem Cell 9:575-87 (2011). PubMed: 22100412
  • Buro LJ  et al. Menin and RNF20 recruitment is associated with dynamic histone modifications that regulate signal transducer and activator of transcription 1 (STAT1)-activated transcription of the interferon regulatory factor 1 gene (IRF1). Epigenetics Chromatin 3:16 (2010). PubMed: 20825659
  • Drouin S  et al. DSIF and RNA polymerase II CTD phosphorylation coordinate the recruitment of Rpd3S to actively transcribed genes. PLoS Genet 6:e1001173 (2010). ChIP . PubMed: 21060864
  • Gordon JA  et al. Pbx1 represses osteoblastogenesis by blocking Hoxa10-mediated recruitment of chromatin remodeling factors. Mol Cell Biol 30:3531-41 (2010). PubMed: 20439491
  • Inagaki S  et al. Autocatalytic differentiation of epigenetic modifications within the Arabidopsis genome. EMBO J 29:3496-506 (2010). PubMed: 20834229
  • Berr A  et al. Arabidopsis histone methyltransferase SET DOMAIN GROUP8 mediates induction of the jasmonate/ethylene pathway genes in plant defense response to necrotrophic fungi. Plant Physiol 154:1403-14 (2010). PubMed: 20810545
  • Berr A  et al. Arabidopsis SET DOMAIN GROUP2 is required for H3K4 trimethylation and is crucial for both sporophyte and gametophyte development. Plant Cell 22:3232-48 (2010). PubMed: 21037105
  • Lin H  et al. Coordinated regulation of active and repressive histone methylations by a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans. Cell Res 20:899-907 (2010). PubMed: 20567262
  • Wood JG  et al. Chromatin remodeling in the aging genome of Drosophila. Aging Cell 9:971-8 (2010). PubMed: 20961390
  • Zhu Z  et al. PHF8 is a histone H3K9me2 demethylase regulating rRNA synthesis. Cell Res 20:794-801 (2010). ChIP . PubMed: 20531378
  • Fang R  et al. Human LSD2/KDM1b/AOF1 Regulates Gene Transcription by Modulating Intragenic H3K4me2 Methylation. Mol Cell 39:222-233 (2010). ChIP . PubMed: 20670891
  • Wei L  et al. Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation. Immunity 32:840-51 (2010). PubMed: 20620946
  • Muramoto T  et al. Methylation of H3K4 Is required for inheritance of active transcriptional states. Curr Biol 20:397-406 (2010). PubMed: 20188556
  • Harris RA  et al. Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. Nat Biotechnol 28:1097-105 (2010). PubMed: 20852635
  • Ko JH  et al. Growth habit determination by the balance of histone methylation activities in Arabidopsis. EMBO J 29:3208-15 (2010). PubMed: 20711170
  • Gómez-del Arco P  et al. Alternative promoter usage at the Notch1 locus supports ligand-independent signaling in T cell development and leukemogenesis. Immunity 33:685-98 (2010). PubMed: 21093322
  • Tanaka Y  et al. JmjC enzyme KDM2A is a regulator of rRNA transcription in response to starvation. EMBO J 29:1510-22 (2010). PubMed: 20379134
  • Loenarz C  et al. PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase. Hum Mol Genet 19:217-22 (2010). WB ; Cow . PubMed: 19843542
  • Lin LJ  et al. Asf1 can promote trimethylation of H3 K36 by Set2. Mol Cell Biol 30:1116-29 (2010). WB ; Saccharomyces cerevisiae . PubMed: 20048053
  • Paakinaho V  et al. Glucocorticoid receptor activates poised FKBP51 locus through long-distance interactions. Mol Endocrinol 24:511-25 (2010). PubMed: 20093418
  • Du HN & Briggs SD A nucleosome surface formed by histone H4, H2A, and H3 residues is needed for proper histone H3 Lys36 methylation, histone acetylation, and repression of cryptic transcription. J Biol Chem 285:11704-13 (2010). ChIP ; Saccharomyces cerevisiae . PubMed: 20139424
  • Gan Q  et al. Monovalent and unpoised status of most genes in undifferentiated cell-enriched Drosophila testis. Genome Biol 11:R42 (2010). ChIP ; Drosophila melanogaster . PubMed: 20398323
  • Lucio-Eterovic AK  et al. Role for the nuclear receptor-binding SET domain protein 1 (NSD1) methyltransferase in coordinating lysine 36 methylation at histone 3 with RNA polymerase II function. Proc Natl Acad Sci U S A 107:16952-7 (2010). Human . PubMed: 20837538
  • Huff JT  et al. Reciprocal intronic and exonic histone modification regions in humans. Nat Struct Mol Biol 17:1495-9 (2010). ChIP ; Human . PubMed: 21057525
  • Sinha KM  et al. Regulation of the osteoblast-specific transcription factor Osterix by NO66, a Jumonji family histone demethylase. EMBO J 29:68-79 (2010). WB . PubMed: 19927124
  • Song YH & Ahn SH A Bre1-associated protein, large 1 (Lge1), promotes H2B ubiquitylation during the early stages of transcription elongation. J Biol Chem 285:2361-7 (2010). WB ; Saccharomyces cerevisiae . PubMed: 19923226
  • Tao Y  et al. Lsh Mediated RNA Polymerase II Stalling at HoxC6 and HoxC8 Involves DNA Methylation. PLoS One 5:e9163 (2010). WB ; Mouse . PubMed: 20161795
  • Sun J & Li R Human negative elongation factor activates transcription and regulates alternative transcription initiation. J Biol Chem 285:6443-52 (2010). ChIP ; Human . PubMed: 20028984
  • Zheng Y  et al. Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate. Nature 463:808-12 (2010). ChIP ; Mouse . PubMed: 20072126
  • Malik S  et al. Rad26p, a transcription-coupled repair factor, is recruited to the site of DNA lesion in an elongating RNA polymerase II-dependent manner in vivo. Nucleic Acids Res 38:1461-77 (2010). ChIP . PubMed: 20007604
  • Wen H  et al. Recognition of Histone H3K4 Trimethylation by the Plant Homeodomain of PHF2 Modulates Histone Demethylation. J Biol Chem 285:9322-6 (2010). ICC/IF ; Human . PubMed: 20129925
  • Huang C  et al. Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4. Cell Res 20:154-65 (2010). WB ; Human . PubMed: 20084082
  • Goldberg AD  et al. Distinct factors control histone variant H3.3 localization at specific genomic regions. Cell 140:678-91 (2010). PubMed: 20211137
  • Vastenhouw NL  et al. Chromatin signature of embryonic pluripotency is established during genome activation. Nature 464:922-6 (2010). WB, ChIP ; Zebrafish . PubMed: 20336069
  • Paul TA  et al. Signatures of polycomb repression and reduced H3K4 trimethylation are associated with p15INK4b DNA methylation in AML. Blood 115:3098-108 (2010). ChIP ; Human . PubMed: 20190193
  • Herz HM  et al. The H3K27me3 demethylase dUTX is a suppressor of notch- and Rb-dependent tumors in Drosophila. Mol Cell Biol 30:2485-97 (2010). IHC ; Drosophila melanogaster . PubMed: 20212086
  • Punga T & Bühler M Long intronic GAA repeats causing Friedreich ataxia impede transcription elongation. EMBO Mol Med 2:120-9 (2010). ChIP ; Human . PubMed: 20373285
  • Yu J  et al. An integrated network of androgen receptor, polycomb, and TMPRSS2-ERG gene fusions in prostate cancer progression. Cancer Cell 17:443-54 (2010). ChIP ; Human . PubMed: 20478527
  • Aiden AP  et al. Wilms tumor chromatin profiles highlight stem cell properties and a renal developmental network. Cell Stem Cell 6:591-602 (2010). ChIP ; Human . PubMed: 20569696
  • Hsia DA  et al. KDM8, a H3K36me2 histone demethylase that acts in the cyclin A1 coding region to regulate cancer cell proliferation. Proc Natl Acad Sci U S A 107:9671-6 (2010). WB ; Human . PubMed: 20457893
  • Duns G  et al. Histone methyltransferase gene SETD2 is a novel tumor suppressor gene in clear cell renal cell carcinoma. Cancer Res 70:4287-91 (2010). WB ; Human . PubMed: 20501857
  • Liu W  et al. PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression. Nature 466:508-12 (2010). WB ; Human . PubMed: 20622854
  • Dhayalan A  et al. The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation. J Biol Chem 285:26114-20 (2010). WB . PubMed: 20547484
  • Pattenden SG  et al. Features of cryptic promoters and their varied reliance on bromodomain-containing factors. PLoS One 5:e12927 (2010). PubMed: 20886085
  • Palma K  et al. Autoimmunity in Arabidopsis acd11 is mediated by epigenetic regulation of an immune receptor. PLoS Pathog 6: (2010). ChIP ; Arabidopsis thaliana . PubMed: 20949080
  • Wirth M  et al. HIS-24 linker histone and SIR-2.1 deacetylase induce H3K27me3 in the Caenorhabditis elegans germ line. Mol Cell Biol 29:3700-9 (2009). IHC-Fr ; Caenorhabditis elegans . PubMed: 19380489
  • Egloff S  et al. Chromatin structure is implicated in "late" elongation checkpoints on the U2 snRNA and beta-actin genes. Mol Cell Biol 29:4002-13 (2009). ChIP ; Human . PubMed: 19451231
  • Hodges E  et al. High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing. Genome Res 19:1593-605 (2009). CHIPseq ; Human . PubMed: 19581485
  • Glover-Cutter K  et al. TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II. Mol Cell Biol 29:5455-64 (2009). PubMed: 19667075
  • Jacinto FV  et al. Impaired recruitment of the histone methyltransferase DOT1L contributes to the incomplete reactivation of tumor suppressor genes upon DNA demethylation. Oncogene 28:4212-24 (2009). ChIP ; Human . PubMed: 19734945
  • Kim T & Buratowski S Dimethylation of H3K4 by Set1 recruits the Set3 histone deacetylase complex to 5' transcribed regions. Cell 137:259-72 (2009). ChIP ; Saccharomyces cerevisiae . PubMed: 19379692
  • Gargiulo G  et al. NA-Seq: a discovery tool for the analysis of chromatin structure and dynamics during differentiation. Dev Cell 16:466-81 (2009). ChIP . PubMed: 19289091
  • Schmitz RJ  et al. Histone H2B deubiquitination is required for transcriptional activation of FLOWERING LOCUS C and for proper control of flowering in Arabidopsis. Plant Physiol 149:1196-204 (2009). WB ; Arabidopsis thaliana . PubMed: 19091875
  • Qiu H  et al. Phosphorylation of the Pol II CTD by KIN28 enhances BUR1/BUR2 recruitment and Ser2 CTD phosphorylation near promoters. Mol Cell 33:752-62 (2009). ChIP . PubMed: 19328068
  • Ciccone DN  et al. KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints. Nature 461:415-8 (2009). ICC/IF ; Mouse . PubMed: 19727073
  • Koshibu K  et al. Protein phosphatase 1 regulates the histone code for long-term memory. J Neurosci 29:13079-89 (2009). WB ; Mouse . PubMed: 19828821
  • Esnault G  et al. Transcription factor CTF1 acts as a chromatin domain boundary that shields human telomeric genes from silencing. Mol Cell Biol 29:2409-18 (2009). ChIP ; Human . PubMed: 19273604
  • Chen Y  et al. DSIF, the Paf1 complex, and Tat-SF1 have nonredundant, cooperative roles in RNA polymerase II elongation. Genes Dev 23:2765-77 (2009). WB ; Human . PubMed: 19952111
  • Makkonen H  et al. Long-range activation of FKBP51 transcription by the androgen receptor via distal intronic enhancers. Nucleic Acids Res 37:4135-48 (2009). ChIP . PubMed: 19433513
  • Luo L  et al. The nuclear periphery of embryonic stem cells is a transcriptionally permissive and repressive compartment. J Cell Sci 122:3729-37 (2009). Xenopus laevis . PubMed: 19773359
  • Psathas JN  et al. Set2-dependent K36 methylation is regulated by novel intratail interactions within H3. Mol Cell Biol 29:6413-26 (2009). WB, ChIP ; Saccharomyces cerevisiae . PubMed: 19822661
  • Santos-Rosa H  et al. Histone H3 tail clipping regulates gene expression. Nat Struct Mol Biol 16:17-22 (2009). WB ; Saccharomyces cerevisiae . PubMed: 19079264
  • Gorchakov AA  et al. Long-range spreading of dosage compensation in Drosophila captures transcribed autosomal genes inserted on X. Genes Dev 23:2266-71 (2009). ChIP ; Drosophila melanogaster . PubMed: 19797766
  • Li Y  et al. The target of the NSD family of histone lysine methyltransferases depends on the nature of the substrate. J Biol Chem 284:34283-95 (2009). PubMed: 19808676
  • Schnetz MP  et al. Genomic distribution of CHD7 on chromatin tracks H3K4 methylation patterns. Genome Res 19:590-601 (2009). WB . PubMed: 19251738
  • Wilson LM  et al. Insulin but not glucagon gene is silenced in human pancreas-derived mesenchymal stem cells. Stem Cells 27:2703-11 (2009). PubMed: 19785038
  • Mestdagh P  et al. A novel and universal method for microRNA RT-qPCR data normalization. Genome Biol 10:R64 (2009). PubMed: 19531210
  • Wang X  et al. Genome-wide and organ-specific landscapes of epigenetic modifications and their relationships to mRNA and small RNA transcriptomes in maize. Plant Cell 21:1053-69 (2009). ChIP . PubMed: 19376930
  • Grini PE  et al. The ASH1 HOMOLOG 2 (ASHH2) histone H3 methyltransferase is required for ovule and anther development in Arabidopsis. PLoS One 4:e7817 (2009). ChIP . PubMed: 19915673
  • Jia L  et al. Functional enhancers at the gene-poor 8q24 cancer-linked locus. PLoS Genet 5:e1000597 (2009). ChIP . PubMed: 19680443
  • Kolasinska-Zwierz P  et al. Differential chromatin marking of introns and expressed exons by H3K36me3. Nat Genet : (2009). ChIP . PubMed: 19182803
  • Tamura T  et al. Inducible deposition of the histone variant H3.3 in interferon-stimulated genes. J Biol Chem 284:12217-25 (2009). PubMed: 19244243
  • Yoh SM  et al. The Iws1:Spt6:CTD complex controls cotranscriptional mRNA biosynthesis and HYPB/Setd2-mediated histone H3K36 methylation. Genes Dev 22:3422-34 (2008). PubMed: 19141475
  • Krivtsov AV  et al. H3K79 methylation profiles define murine and human MLL-AF4 leukemias. Cancer Cell 14:355-68 (2008). PubMed: 18977325
  • Rabinovich A  et al. E2F in vivo binding specificity: comparison of consensus versus nonconsensus binding sites. Genome Res 18:1763-77 (2008). PubMed: 18836037
  • Ku M  et al. Genomewide analysis of PRC1 and PRC2 occupancy identifies two classes of bivalent domains. PLoS Genet 4:e1000242 (2008). ChIP . PubMed: 18974828
  • Biswas D  et al. Different genetic functions for the Rpd3(L) and Rpd3(S) complexes suggest competition between NuA4 and Rpd3(S). Mol Cell Biol 28:4445-58 (2008). ChIP . PubMed: 18490440
  • Han Y  et al. Orientation-dependent regulation of integrated HIV-1 expression by host gene transcriptional readthrough. Cell Host Microbe 4:134-46 (2008). ChIP . PubMed: 18692773
  • Lian Z  et al. A genomic analysis of RNA polymerase II modification and chromatin architecture related to 3' end RNA polyadenylation. Genome Res 18:1224-37 (2008). PubMed: 18487515
  • Racanelli AC  et al. A mouse gene that coordinates epigenetic controls and transcriptional interference to achieve tissue-specific expression. Mol Cell Biol 28:836-48 (2008). ChIP ; Mouse . PubMed: 17998333
  • Nelson JD  et al. Transcription of laminin gamma1 chain gene in rat mesangial cells: constitutive and inducible RNA polymerase II recruitment and chromatin states. Am J Physiol Renal Physiol 294:F525-33 (2008). ChIP ; Rat . PubMed: 18184742
  • Sun XJ  et al. Genome-wide survey and developmental expression mapping of zebrafish SET domain-containing genes. PLoS One 3:e1499 (2008). IHC ; Zebrafish . PubMed: 18231586
  • Merker JD  et al. The histone methylase Set2p and the histone deacetylase Rpd3p repress meiotic recombination at the HIS4 meiotic recombination hotspot in Saccharomyces cerevisiae. DNA Repair (Amst) 7:1298-308 (2008). ChIP ; Saccharomyces cerevisiae . PubMed: 18515193
  • Postberg J  et al. Spatial and temporal plasticity of chromatin during programmed DNA-reorganization in Stylonychia macronuclear development. Epigenetics Chromatin 1:3 (2008). PubMed: 19014664
  • Edmunds JW  et al. Dynamic histone H3 methylation during gene induction: HYPB/Setd2 mediates all H3K36 trimethylation. EMBO J 27:406-20 (2008). ChIP ; Mouse . PubMed: 18157086
  • Williams A  et al. Position effect variegation and imprinting of transgenes in lymphocytes. Nucleic Acids Res 36:2320-9 (2008). ChIP ; Mouse . PubMed: 18296483
  • Lloret-Llinares M  et al. Characterization of Drosophila melanogaster JmjC+N histone demethylases. Nucleic Acids Res : (2008). ICC/IF ; Drosophila melanogaster . PubMed: 18375980
  • Smith ER  et al. Drosophila UTX is a histone H3 Lys27 demethylase that colocalizes with the elongating form of RNA polymerase II. Mol Cell Biol 28:1041-6 (2008). WB ; Drosophila melanogaster . PubMed: 18039863
  • Xu L  et al. Di- and tri- but not monomethylation on histone H3 lysine 36 marks active transcription of genes involved in flowering time regulation and other processes in Arabidopsis thaliana. Mol Cell Biol 28:1348-60 (2008). WB ; Arabidopsis thaliana . PubMed: 18070919
  • Chou SD & Tomasi TB Spatial distribution of histone methylation during MHC class II expression. Mol Immunol 45:971-80 (2008). PubMed: 17850872
  • Steger DJ  et al. DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. Mol Cell Biol 28:2825-39 (2008). ChIP ; Mouse . PubMed: 18285465
  • Bell O  et al. Transcription-coupled methylation of histone H3 at lysine 36 regulates dosage compensation by enhancing recruitment of the MSL complex in Drosophila melanogaster. Mol Cell Biol 28:3401-9 (2008). WB ; Drosophila melanogaster . PubMed: 18347056
  • Lagarou A  et al. dKDM2 couples histone H2A ubiquitylation to histone H3 demethylation during Polycomb group silencing. Genes Dev 22:2799-810 (2008). WB ; Drosophila melanogaster . PubMed: 18923078
  • Vitaliano-Prunier A  et al. Ubiquitylation of the COMPASS component Swd2 links H2B ubiquitylation to H3K4 trimethylation. Nat Cell Biol 10:1365-71 (2008). WB ; Saccharomyces cerevisiae . PubMed: 18849979
  • De Santa F  et al. The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing. Cell 130:1083-94 (2007). WB, ICC/IF ; Human . PubMed: 17825402
  • Ingvarsdottir K  et al. Histone H3 K4 demethylation during activation and attenuation of GAL1 transcription in Saccharomyces cerevisiae. Mol Cell Biol 27:7856-64 (2007). PubMed: 17875926
  • Andersen EC & Horvitz HR Two C. elegans histone methyltransferases repress lin-3 EGF transcription to inhibit vulval development. Development 134:2991-9 (2007). WB ; Caenorhabditis elegans . PubMed: 17634190
  • Yokoyama R  et al. A plasmid model system shows that Drosophila dosage compensation depends on the global acetylation of histone H4 at lysine 16 and is not affected by depletion of common transcription elongation chromatin marks. Mol Cell Biol 27:7865-70 (2007). PubMed: 17875941
  • Gregory GD  et al. Mammalian ASH1L is a histone methyltransferase that occupies the transcribed region of active genes. Mol Cell Biol 27:8466-79 (2007). PubMed: 17923682
  • Fang J  et al. The Saccharomyces cerevisiae histone demethylase Jhd1 fine-tunes the distribution of H3K36me2. Mol Cell Biol 27:5055-65 (2007). WB, ChIP . PubMed: 17470555
  • Lee MG  et al. Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein. Cell 128:877-87 (2007). WB ; Human . PubMed: 17320162
  • Wang GG  et al. NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemogenesis. Nat Cell Biol 9:804-12 (2007). ChIP ; Mouse . PubMed: 17589499
  • Larschan E  et al. MSL complex is attracted to genes marked by H3K36 trimethylation using a sequence-independent mechanism. Mol Cell 28:121-33 (2007). ChIP/Chip ; Drosophila melanogaster . PubMed: 17936709
  • Secombe J  et al. The Trithorax group protein Lid is a trimethyl histone H3K4 demethylase required for dMyc-induced cell growth. Genes Dev 21:537-51 (2007). PubMed: 17311883
  • Barski A  et al. High-resolution profiling of histone methylations in the human genome. Cell 129:823-37 (2007). PubMed: 17512414
  • Guenther MG  et al. A chromatin landmark and transcription initiation at most promoters in human cells. Cell 130:77-88 (2007). ChIP/Chip ; Human . PubMed: 17632057
  • Hayakawa T  et al. RBP2 is an MRG15 complex component and down-regulates intragenic histone H3 lysine 4 methylation. Genes Cells 12:811-26 (2007). WB ; Human . PubMed: 17573780
  • Klose RJ  et al. Demethylation of histone H3K36 and H3K9 by Rph1: a vestige of an H3K9 methylation system in Saccharomyces cerevisiae? Mol Cell Biol 27:3951-61 (2007). WB ; Saccharomyces cerevisiae . PubMed: 17371840
  • Morris SA  et al. Identification of histone H3 lysine 36 acetylation as a highly conserved histone modification. J Biol Chem 282:7632-40 (2007). WB ; Saccharomyces cerevisiae . PubMed: 17189264
  • Chu Y  et al. Regulation of histone modification and cryptic transcription by the Bur1 and Paf1 complexes. EMBO J 26:4646-56 (2007). WB ; Saccharomyces cerevisiae . PubMed: 17948059
  • Abarrategui I & Krangel MS Noncoding transcription controls downstream promoters to regulate T-cell receptor alpha recombination. EMBO J 26:4380-90 (2007). WB ; Mouse . PubMed: 17882258
  • Agger K  et al. UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nature 449:731-4 (2007). WB, ICC/IF ; Human . PubMed: 17713478
  • Hong S  et al. Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases. Proc Natl Acad Sci U S A 104:18439-44 (2007). PubMed: 18003914
  • Xiao T  et al. The RNA polymerase II kinase Ctk1 regulates positioning of a 5' histone methylation boundary along genes. Mol Cell Biol 27:721-31 (2007). PubMed: 17088384
  • Rybtsova N  et al. Transcription-coupled deposition of histone modifications during MHC class II gene activation. Nucleic Acids Res 35:3431-41 (2007). PubMed: 17478518
  • Kim T & Buratowski S Two Saccharomyces cerevisiae JmjC domain proteins demethylate histone H3 Lys36 in transcribed regions to promote elongation. J Biol Chem 282:20827-35 (2007). PubMed: 17525156
  • Mikkelsen TS  et al. Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Nature 448:553-60 (2007). PubMed: 17603471
  • Kirmizis A  et al. Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation. Nature 449:928-32 (2007). WB ; Saccharomyces cerevisiae . PubMed: 17898715
  • Guccione E  et al. Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive. Nature 449:933-7 (2007). ChIP ; Human . PubMed: 17898714
  • Christensen J  et al. RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3. Cell 128:1063-76 (2007). PubMed: 17320161
  • Riu E  et al. Histone modifications are associated with the persistence or silencing of vector-mediated transgene expression in vivo. Mol Ther 15:1348-55 (2007). PubMed: 17457320
  • Sripathy SP  et al. The KAP1 corepressor functions to coordinate the assembly of de novo HP1-demarcated microenvironments of heterochromatin required for KRAB zinc finger protein-mediated transcriptional repression. Mol Cell Biol 26:8623-38 (2006). ChIP . PubMed: 16954381
  • Chu Y  et al. The BUR1 cyclin-dependent protein kinase is required for the normal pattern of histone methylation by SET2. Mol Cell Biol 26:3029-38 (2006). WB ; Saccharomyces cerevisiae . PubMed: 16581778
  • Zhang P  et al. Structure of human MRG15 chromo domain and its binding to Lys36-methylated histone H3. Nucleic Acids Res 34:6621-8 (2006). PubMed: 17135209
  • Vakoc CR  et al. Profile of histone lysine methylation across transcribed mammalian chromatin. Mol Cell Biol 26:9185-95 (2006). PubMed: 17030614
  • Whetstine JR  et al. Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. Cell 125:467-81 (2006). PubMed: 16603238
  • Guccione E  et al. Myc-binding-site recognition in the human genome is determined by chromatin context. Nat Cell Biol 8:764-70 (2006). PubMed: 16767079
  • Nelson CJ  et al. Proline isomerization of histone H3 regulates lysine methylation and gene expression. Cell 126:905-16 (2006). PubMed: 16959570
  • Loyola A  et al. PTMs on H3 variants before chromatin assembly potentiate their final epigenetic state. Mol Cell 24:309-16 (2006). PubMed: 17052464
  • Bannister AJ  et al. Spatial distribution of Di- and tri-methyl lysine 36 of histone H3 at active genes. J Biol Chem 280:17732-6 (2005). PubMed: 15760899
  • Pokholok DK  et al. Genome-wide map of nucleosome acetylation and methylation in yeast. Cell 122:517-27 (2005). PubMed: 16122420
  • Morillon A  et al. Dynamic lysine methylation on histone H3 defines the regulatory phase of gene transcription. Mol Cell 18:723-34 (2005). PubMed: 15949446

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

注册