Anti-Histone H3 (di methyl K79)抗体- ChIP Grade (ab3594)

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ab3594 被引用在 123 文献中.

  • Zhang X  et al. Prognostic and therapeutic value of disruptor of telomeric silencing-1-like (DOT1L) expression in patients with ovarian cancer. J Hematol Oncol 10:29 (2017). IHC-P ; Human . PubMed: 28114995
  • Moretti C  et al. SLY regulates genes involved in chromatin remodeling and interacts with TBL1XR1 during sperm differentiation. Cell Death Differ 24:1029-1044 (2017). WB, IF, ChIP ; Mouse . PubMed: 28475176
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  • Rau RE  et al. DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia. Blood 128:971-81 (2016). CHIPseq ; Mouse . PubMed: 27335278
  • Ahn JH  et al. A Conserved Nuclear Cyclophilin Is Required for Both RNA Polymerase II Elongation and Co-transcriptional Splicing in Caenorhabditis elegans. PLoS Genet 12:e1006227 (2016). WB ; Caenorhabditis elegans . PubMed: 27541139
  • Sun J  et al. Pax6 associates with H3K4-specific histone methyltransferases Mll1, Mll2, and Set1a and regulates H3K4 methylation at promoters and enhancers. Epigenetics Chromatin 9:37 (2016). PubMed: 27617035
  • Cano-Rodriguez D  et al. Writing of H3K4Me3 overcomes epigenetic silencing in a sustained but context-dependent manner. Nat Commun 7:12284 (2016). ChIP . PubMed: 27506838
  • Barbutti I  et al. CATS (FAM64A) abnormal expression reduces clonogenicity of hematopoietic cells. Oncotarget 7:68385-68396 (2016). WB . PubMed: 27588395
  • Steunou AL  et al. Combined Action of Histone Reader Modules Regulates NuA4 Local Acetyltransferase Function but Not Its Recruitment on the Genome. Mol Cell Biol 36:2768-2781 (2016). PubMed: 27550811
  • Jackson SA  et al. Alternative Routes to Induced Pluripotent Stem Cells Revealed by Reprogramming of the Neural Lineage. Stem Cell Reports 6:302-11 (2016). WB . PubMed: 26905202
  • He S  et al. Menin-MLL inhibitors block oncogenic transformation by MLL-fusion proteins in a fusion partner-independent manner. Leukemia 30:508-13 (2016). PubMed: 26084867
  • Duan Y  et al. DOT1L promotes angiogenesis through cooperative regulation of VEGFR2 with ETS-1. Oncotarget 7:69674-69687 (2016). PubMed: 27626484
  • Riedel SS  et al. MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia. J Clin Invest 126:1438-50 (2016). PubMed: 26927674
  • Mitsuda SH & Shimizu N Epigenetic Repeat-Induced Gene Silencing in the Chromosomal and Extrachromosomal Contexts in Human Cells. PLoS One 11:e0161288 (2016). ChIP ; Human . PubMed: 27525955
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  • Konno M  et al. Embryonic MicroRNA-369 Controls Metabolic Splicing Factors and Urges Cellular Reprograming. PLoS One 10:e0132789 (2015). ChIP ; Mouse . PubMed: 26176628
  • Ji X  et al. Chromatin proteomic profiling reveals novel proteins associated with histone-marked genomic regions. Proc Natl Acad Sci U S A 112:3841-6 (2015). WB, ChIP, CHIPseq ; Mouse . PubMed: 25755260
  • Lu S  et al. The transcription factor c-Fos coordinates with histone lysine-specific demethylase 2A to activate the expression of cyclooxygenase-2. Oncotarget 6:34704-17 (2015). WB . PubMed: 26430963
  • Howe CG & Gamble MV Enzymatic cleavage of histone H3: a new consideration when measuring histone modifications in human samples. Clin Epigenetics 7:7 (2015). PubMed: 25628766
  • Kuntimaddi A  et al. Degree of recruitment of DOT1L to MLL-AF9 defines level of H3K79 Di- and tri-methylation on target genes and transformation potential. Cell Rep 11:808-20 (2015). PubMed: 25921540
  • Chen CW  et al. DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia. Nat Med 21:335-43 (2015). PubMed: 25822366
  • Rothbart SB  et al. An Interactive Database for the Assessment of Histone Antibody Specificity. Mol Cell 59:502-11 (2015). PubMed: 26212453
  • Wong SH  et al. The H3K4-Methyl Epigenome Regulates Leukemia Stem Cell Oncogenic Potential. Cancer Cell 28:198-209 (2015). ChIP ; Mouse, Human . PubMed: 26190263
  • Yao X  et al. The Mediator subunit MED23 couples H2B mono-ubiquitination to transcriptional control and cell fate determination. EMBO J 34:2885-902 (2015). WB . PubMed: 26330467
  • Cho MH  et al. DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression. Nat Commun 6:7821 (2015). PubMed: 26199140
  • Takahashi JS  et al. ChIP-seq and RNA-seq methods to study circadian control of transcription in mammals. Methods Enzymol 551:285-321 (2015). PubMed: 25662462
  • Magraner-Pardo L  et al. Dynamic remodeling of histone modifications in response to osmotic stress in Saccharomyces cerevisiae. BMC Genomics 15:247 (2014). ChIP . PubMed: 24678875
  • Kryczek I  et al. IL-22(+)CD4(+) T cells promote colorectal cancer stemness via STAT3 transcription factor activation and induction of the methyltransferase DOT1L. Immunity 40:772-784 (2014). PubMed: 24816405
  • van der Linden MH  et al. MLL fusion-driven activation of CDK6 potentiates proliferation in MLL-rearranged infant ALL. Cell Cycle 13:834-44 (2014). PubMed: 24736461
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  • Flach J  et al. Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells. Nature 512:198-202 (2014). ICC/IF . PubMed: 25079315
  • Dottermusch-Heidel C  et al. H3K79 methylation: a new conserved mark that accompanies H4 hyperacetylation prior to histone-to-protamine transition in Drosophila and rat. Biol Open 3:444-52 (2014). IF ; Drosophila melanogaster . PubMed: 24795146
  • O'Connor CM  et al. Quantitative proteomic discovery of dynamic epigenome changes that control human cytomegalovirus (HCMV) infection. Mol Cell Proteomics 13:2399-410 (2014). PubMed: 24987098
  • Fuchs G  et al. Cotranscriptional histone H2B monoubiquitylation is tightly coupled with RNA polymerase II elongation rate. Genome Res 24:1572-83 (2014). PubMed: 25049226
  • Ohlsson E  et al. Initiation of MLL-rearranged AML is dependent on C/EBPa. J Exp Med 211:5-13 (2014). ChIP . PubMed: 24367003
  • Hammond SL  et al. Mitotic phosphorylation of histone H3 threonine 80. Cell Cycle 13:440-52 (2014). Human . PubMed: 24275038
  • Suzuki MG  et al. Effects of RNAi-mediated knockdown of histone methyltransferases on the sex-specific mRNA expression of Imp in the silkworm Bombyx mori. Int J Mol Sci 15:6772-96 (2014). ChIP ; Silk worm . PubMed: 24758924
  • Zhang H  et al. Uncoupling transcription from covalent histone modification. PLoS Genet 10:e1004202 (2014). ChIP . PubMed: 24722509
  • Long L  et al. The U4/U6 recycling factor SART3 has histone chaperone activity and associates with USP15 to regulate H2B deubiquitination. J Biol Chem 289:8916-30 (2014). PubMed: 24526689
  • Liu W  et al. DOT1L inhibition sensitizes MLL-rearranged AML to chemotherapy. PLoS One 9:e98270 (2014). WB ; Human . PubMed: 24858818
  • Dottermusch-Heidel C  et al. H3K79 methylation directly precedes the histone-to-protamine transition in mammalian spermatids and is sensitive to bacterial infections. Andrology 2:655-65 (2014). IHC-P ; Human . PubMed: 25079683
  • Ho LL  et al. DOT1L-mediated H3K79 methylation in chromatin is dispensable for Wnt pathway-specific and other intestinal epithelial functions. Mol Cell Biol 33:1735-45 (2013). WB, IHC-P, IHC-Fr ; Mouse . PubMed: 23428873
  • Chen L  et al. Abrogation of MLL-AF10 and CALM-AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l. Leukemia 27:813-22 (2013). PubMed: 23138183
  • Wang E  et al. Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia. Proc Natl Acad Sci U S A 110:3901-6 (2013). PubMed: 23412334
  • Kuo HP  et al. Epigenetic roles of MLL oncoproteins are dependent on NF-?B. Cancer Cell 24:423-37 (2013). ChIP ; Mouse . PubMed: 24054986
  • Sadhu MJ  et al. Nutritional control of epigenetic processes in yeast and human cells. Genetics 195:831-44 (2013). Human . PubMed: 23979574
  • Papait R  et al. Genome-wide analysis of histone marks identifying an epigenetic signature of promoters and enhancers underlying cardiac hypertrophy. Proc Natl Acad Sci U S A 110:20164-9 (2013). Mouse . PubMed: 24284169
  • Ooga M  et al. Involvement of DOT1L in the remodeling of heterochromatin configuration during early preimplantation development in mice. Biol Reprod 89:145 (2013). IHC-P ; Mouse . PubMed: 24132959
  • Mazzoni EO  et al. Saltatory remodeling of Hox chromatin in response to rostrocaudal patterning signals. Nat Neurosci 16:1191-8 (2013). ChIP/Chip . PubMed: 23955559
  • Wu H  et al. Aqp5 is a new transcriptional target of Dot1a and a regulator of Aqp2. PLoS One 8:e53342 (2013). ICC/IF ; Mouse . PubMed: 23326416
  • Hatzi K  et al. A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters. Cell Rep 4:578-88 (2013). ChIP . PubMed: 23911289
  • Lai Z  et al. Msl2 is a novel component of the vertebrate DNA damage response. PLoS One 8:e68549 (2013). WB . PubMed: 23874665
  • Fu H  et al. Methylation of histone H3 on lysine 79 associates with a group of replication origins and helps limit DNA replication once per cell cycle. PLoS Genet 9:e1003542 (2013). WB ; Human . PubMed: 23754963
  • Ontoso D  et al. Dynamics of DOT1L localization and H3K79 methylation during meiotic prophase I in mouse spermatocytes. Chromosoma : (2013). IF . PubMed: 24105599
  • Chan KM  et al. A lesson learned from the H3.3K27M mutation found in pediatric glioma: a new approach to the study of the function of histone modifications in vivo? Cell Cycle 12:2546-52 (2013). PubMed: 23907119
  • Wu F & Yao J Spatial compartmentalization at the nuclear periphery characterized by genome-wide mapping. BMC Genomics 14:591 (2013). PubMed: 23987233
  • Sabra M  et al. The Tudor protein survival motor neuron (SMN) is a chromatin-binding protein that interacts with methylated lysine 79 of histone H3. J Cell Sci 126:3664-77 (2013). PubMed: 23750013
  • Ulanovskaya OA  et al. NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink. Nat Chem Biol 9:300-6 (2013). WB . PubMed: 23455543
  • Lepoivre C  et al. Divergent transcription is associated with promoters of transcriptional regulators. BMC Genomics 14:914 (2013). ChIP . PubMed: 24365181
  • Faure AJ  et al. Cohesin regulates tissue-specific expression by stabilizing highly occupied cis-regulatory modules. Genome Res 22:2163-75 (2012). PubMed: 22780989
  • Yu W  et al. Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors. Nat Commun 3:1288 (2012). PubMed: 23250418
  • Maia AT  et al. Effects of BRCA2 cis-regulation in normal breast and cancer risk amongst BRCA2 mutation carriers. Breast Cancer Res 14:R63 (2012). ChIP . PubMed: 22513257
  • Youn MY  et al. JMJD5, a Jumonji C (JmjC) Domain-containing Protein, Negatively Regulates Osteoclastogenesis by Facilitating NFATc1 Protein Degradation. J Biol Chem 287:12994-3004 (2012). WB ; Human . PubMed: 22375008
  • Bjørnstad LG  et al. Human ALKBH4 interacts with proteins associated with transcription. PLoS One 7:e49045 (2012). WB . PubMed: 23145062
  • Kohler KM  et al. Identification of core DNA elements that target somatic hypermutation. J Immunol 189:5314-26 (2012). ChIP . PubMed: 23087403
  • Bindels EM  et al. EVI1 is critical for the pathogenesis of a subset of MLL-AF9-rearranged AMLs. Blood 119:5838-49 (2012). ChIP ; Human . PubMed: 22553314
  • Motwani T  et al. Sir3 and epigenetic inheritance of silent chromatin in Saccharomyces cerevisiae. Mol Cell Biol 32:2784-93 (2012). ChIP . PubMed: 22586263
  • Ma MK  et al. Histone crosstalk directed by H2B ubiquitination is required for chromatin boundary integrity. PLoS Genet 7:e1002175 (2011). PubMed: 21811414
  • FitzGerald J  et al. Regulation of the DNA damage response and gene expression by the Dot1L histone methyltransferase and the 53Bp1 tumour suppressor. PLoS One 6:e14714 (2011). WB . PubMed: 21383990
  • He N  et al. Human Polymerase-Associated Factor complex (PAFc) connects the Super Elongation Complex (SEC) to RNA polymerase II on chromatin. Proc Natl Acad Sci U S A 108:E636-45 (2011). PubMed: 21873227
  • Abe K  et al. Loss of Heterochromatin Protein 1 Gamma Reduces the Number of Primordial Germ Cells via Impaired Cell-Cycle Progression in Mice. Biol Reprod : (2011). PubMed: 21778144
  • Wang QF  et al. MLL fusion proteins preferentially regulate a subset of wild-type MLL target genes in the leukemic genome. Blood 117:6895-905 (2011). PubMed: 21518926
  • Vernimmen D  et al. Polycomb eviction as a new distant enhancer function. Genes Dev 25:1583-8 (2011). ChIP ; Mouse . PubMed: 21828268
  • Milcarek C  et al. The Eleven-Nineteen Lysine-rich Leukemia Gene (ELL2) Influences the Histone H3 Protein Modifications Accompanying the Shift to Secretory Immunoglobulin Heavy Chain mRNA Production. J Biol Chem 286:33795-803 (2011). ChIP ; Mouse . PubMed: 21832080
  • Ram O  et al. Combinatorial patterning of chromatin regulators uncovered by genome-wide location analysis in human cells. Cell 147:1628-39 (2011). CHIPseq ; Human . PubMed: 22196736
  • Fossati A  et al. NF-Y recruits Ash2L to impart H3K4 trimethylation on CCAAT promoters. PLoS One 6:e17220 (2011). ChIP . PubMed: 21445285
  • Wong P  et al. Gene induction and repression during terminal erythropoiesis are mediated by distinct epigenetic changes. Blood 118:e128-38 (2011). ChIP . PubMed: 21860024
  • Lin H  et al. Coordinated regulation of active and repressive histone methylations by a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans. Cell Res 20:899-907 (2010). PubMed: 20567262
  • Zhu Z  et al. PHF8 is a histone H3K9me2 demethylase regulating rRNA synthesis. Cell Res 20:794-801 (2010). ChIP . PubMed: 20531378
  • Stitzel ML  et al. Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci. Cell Metab 12:443-55 (2010). ChIP . PubMed: 21035756
  • Feng Y  et al. Early mammalian erythropoiesis requires the Dot1L methyltransferase. Blood 116:4483-91 (2010). PubMed: 20798234
  • Tao Y  et al. Lsh Mediated RNA Polymerase II Stalling at HoxC6 and HoxC8 Involves DNA Methylation. PLoS One 5:e9163 (2010). WB ; Mouse . PubMed: 20161795
  • Juszczynski P  et al. MLL-rearranged B lymphoblastic leukemias selectively express the immunoregulatory carbohydrate-binding protein galectin-1. Clin Cancer Res 16:2122-30 (2010). ChIP ; Human . PubMed: 20332322
  • Büttner N  et al. Af9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of the cerebral cortex. Proc Natl Acad Sci U S A : (2010). ChIP ; Mouse . PubMed: 20348416
  • Lee HS  et al. A cooperative activation loop among SWI/SNF, gamma-H2AX and H3 acetylation for DNA double-strand break repair. EMBO J 29:1434-45 (2010). WB ; Human . PubMed: 20224553
  • Kanhere A  et al. Short RNAs are transcribed from repressed polycomb target genes and interact with polycomb repressive complex-2. Mol Cell 38:675-88 (2010). PubMed: 20542000
  • Liu W  et al. PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression. Nature 466:508-12 (2010). WB ; Human . PubMed: 20622854
  • Turner EL  et al. The Saccharomyces cerevisiae anaphase-promoting complex interacts with multiple histone-modifying enzymes to regulate cell cycle progression. Eukaryot Cell 9:1418-31 (2010). WB ; Saccharomyces cerevisiae . PubMed: 20709786
  • Huff JT  et al. Reciprocal intronic and exonic histone modification regions in humans. Nat Struct Mol Biol 17:1495-9 (2010). ChIP ; Human . PubMed: 21057525
  • Gargiulo G  et al. NA-Seq: a discovery tool for the analysis of chromatin structure and dynamics during differentiation. Dev Cell 16:466-81 (2009). ChIP . PubMed: 19289091
  • Esnault G  et al. Transcription factor CTF1 acts as a chromatin domain boundary that shields human telomeric genes from silencing. Mol Cell Biol 29:2409-18 (2009). ChIP ; Human . PubMed: 19273604
  • Rivas M  et al. The DREAM protein is associated with thyroid enlargement and nodular development. Mol Endocrinol 23:862-70 (2009). PubMed: 19299442
  • Mueller D  et al. Misguided transcriptional elongation causes mixed lineage leukemia. PLoS Biol 7:e1000249 (2009). ChIP ; Mouse . PubMed: 19956800
  • Tjeertes JV  et al. Screen for DNA-damage-responsive histone modifications identifies H3K9Ac and H3K56Ac in human cells. EMBO J 28:1878-89 (2009). WB ; Human . PubMed: 19407812
  • Chen Y  et al. DSIF, the Paf1 complex, and Tat-SF1 have nonredundant, cooperative roles in RNA polymerase II elongation. Genes Dev 23:2765-77 (2009). WB ; Human . PubMed: 19952111
  • Jacinto FV  et al. Impaired recruitment of the histone methyltransferase DOT1L contributes to the incomplete reactivation of tumor suppressor genes upon DNA demethylation. Oncogene 28:4212-24 (2009). WB, ChIP ; Human . PubMed: 19734945
  • Conde F  et al. The Dot1 histone methyltransferase and the Rad9 checkpoint adaptor contribute to cohesin-dependent double-strand break repair by sister chromatid recombination in Saccharomyces cerevisiae. Genetics 182:437-46 (2009). PubMed: 19332880
  • Wilson LM  et al. Insulin but not glucagon gene is silenced in human pancreas-derived mesenchymal stem cells. Stem Cells 27:2703-11 (2009). PubMed: 19785038
  • Krivtsov AV  et al. H3K79 methylation profiles define murine and human MLL-AF4 leukemias. Cancer Cell 14:355-68 (2008). PubMed: 18977325
  • Ooga M  et al. Changes in H3K79 methylation during preimplantation development in mice. Biol Reprod 78:413-24 (2008). PubMed: 18003948
  • Donati G  et al. An NF-Y-dependent switch of positive and negative histone methyl marks on CCAAT promoters. PLoS ONE 3:e2066 (2008). ChIP ; Human . PubMed: 18446193
  • Frederiks F  et al. Nonprocessive methylation by Dot1 leads to functional redundancy of histone H3K79 methylation states. Nat Struct Mol Biol 15:550-7 (2008). WB . PubMed: 18511943
  • Chou SD & Tomasi TB Spatial distribution of histone methylation during MHC class II expression. Mol Immunol 45:971-80 (2008). PubMed: 17850872
  • Steger DJ  et al. DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. Mol Cell Biol 28:2825-39 (2008). ChIP ; Mouse . PubMed: 18285465
  • Jones B  et al. The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure. PLoS Genet 4:e1000190 (2008). WB ; Mouse . PubMed: 18787701
  • Vitaliano-Prunier A  et al. Ubiquitylation of the COMPASS component Swd2 links H2B ubiquitylation to H3K4 trimethylation. Nat Cell Biol 10:1365-71 (2008). WB ; Saccharomyces cerevisiae . PubMed: 18849979
  • Martinato F  et al. Analysis of Myc-induced histone modifications on target chromatin. PLoS ONE 3:e3650 (2008). ChIP ; Human . PubMed: 18985155
  • Rabinovich A  et al. E2F in vivo binding specificity: comparison of consensus versus nonconsensus binding sites. Genome Res 18:1763-77 (2008). ChIP . PubMed: 18836037
  • Nelson JD  et al. Transcription of laminin gamma1 chain gene in rat mesangial cells: constitutive and inducible RNA polymerase II recruitment and chromatin states. Am J Physiol Renal Physiol 294:F525-33 (2008). ChIP ; Rat . PubMed: 18184742
  • Barski A  et al. High-resolution profiling of histone methylations in the human genome. Cell 129:823-37 (2007). PubMed: 17512414
  • Chang B  et al. JMJD6 is a histone arginine demethylase. Science 318:444-7 (2007). WB ; Human . PubMed: 17947579
  • Guenther MG  et al. A chromatin landmark and transcription initiation at most promoters in human cells. Cell 130:77-88 (2007). ChIP/Chip ; Human . PubMed: 17632057
  • De Santa F  et al. The histone H3 lysine-27 demethylase Jmjd3 links inflammation to inhibition of polycomb-mediated gene silencing. Cell 130:1083-94 (2007). WB ; Human . PubMed: 17825402
  • Ingvarsdottir K  et al. Histone H3 K4 demethylation during activation and attenuation of GAL1 transcription in Saccharomyces cerevisiae. Mol Cell Biol 27:7856-64 (2007). PubMed: 17875926
  • Riu E  et al. Histone modifications are associated with the persistence or silencing of vector-mediated transgene expression in vivo. Mol Ther 15:1348-55 (2007). PubMed: 17457320
  • Guccione E  et al. Myc-binding-site recognition in the human genome is determined by chromatin context. Nat Cell Biol 8:764-70 (2006). PubMed: 16767079
  • Donati G  et al. Dynamic recruitment of transcription factors and epigenetic changes on the ER stress response gene promoters. Nucleic Acids Res 34:3116-27 (2006). IP ; Human . PubMed: 16757577
  • Morillon A  et al. Dynamic lysine methylation on histone H3 defines the regulatory phase of gene transcription. Mol Cell 18:723-34 (2005). PubMed: 15949446
  • Huyen Y  et al. Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks. Nature 432:406-11 (2004). PubMed: 15525939

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